Review article: is stringent control of gastric pH useful and practical in GERD?

abstract：BACKGROUND:Much recent effort has been made to produce selective inhibitors of cyclo-oxygenase-2 (COX-2) in the belief that these will lack the gastrointestinal damaging effects of traditional non-steroidal anti-inflammatory drugs (NSAIDs). Inflammatory bowel disease is associated with increased local production of pro...

journal_title：Alimentary pharmacology & therapeutics

authors： McCartney SA,Mitchell JA,Fairclough PD,Farthing MJ,Warner TD

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Triple therapy (proton pump inhibitor, clarithromycin and amoxicillin or an imidazole) is the first-line treatment for Helicobacter pylori infection. However, the effectiveness of triple therapy is decreasing due to the increase in antibiotic resistance. Quadruple therapy (proton pump inhibitor, tetracycline...

journal_title：Alimentary pharmacology & therapeutics

authors： Gené E,Calvet X,Azagra R,Gisbert JP

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:The incidence of irritable bowel syndrome is uncertain. We aimed to determine the incidence of clinically diagnosed irritable bowel syndrome in the community. METHODS:Using the Rochester Epidemiology Project, all diagnoses of irritable bowel syndrome made among adult residents of Olmsted County, Minnesota, ...

journal_title：Alimentary pharmacology & therapeutics

authors： Locke GR 3rd,Yawn BP,Wollan PC,Melton LJ 3rd,Lydick E,Talley NJ

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Aminosalicylates are the most frequently prescribed treatment for ulcerative colitis (UC). In the absence of empirical evidence, clinicians are uncertain whether to continue aminosalicylates in patients with UC after escalating therapy. AIMS:To quantify concomitant aminosalicylate use in UC randomised clini...

journal_title：Alimentary pharmacology & therapeutics

authors： Ma C,Guizzetti L,Cipriano LE,Parker CE,Nguyen TM,Gregor JC,Chande N,Feagan BG,Jairath V

更新日期：2019-02-01 00:00:00

abstract：:Methotrexate has a place in the treatment of an increasing number of diseases. Its emerging role in the treatment of primary biliary cirrhosis and inflammatory bowel disease still requires further evaluation. Its toxicity profile is wide and is affected by a variety of factors. Hepatotoxicity from long-term use in pat...

journal_title：Alimentary pharmacology & therapeutics

authors： Tang H,Neuberger J

更新日期：1996-12-01 00:00:00

abstract：:To commemorate Edkins' discovery of gastrin in 1905, we review a century of progress in the physiology and pathobiology of gastrin and acid secretion especially as it pertains to clinical aspects of gastro-oesophageal reflux disease. Although initially ignored, Edkins' observations eventually led to the enthusiastic i...

journal_title：Alimentary pharmacology & therapeutics

authors： Malfertheiner P,Fass R,Quigley EM,Modlin IM,Malagelada JR,Moss SF,Holtmann G,Goh KL,Katelaris P,Stanghellini V,Talley NJ,Tytgat GN,Wright NA

更新日期：2006-03-15 00:00:00

abstract：BACKGROUND:A large proportion (25-46%) of adults with inflammatory bowel disease in remission has symptoms of irritable bowel syndrome (IBS), which are thought to reflect ongoing inflammation. Data on paediatric inflammatory bowel disease patients are lacking. AIM:To investigate (i) the prevalence of IBS-type symptoms...

journal_title：Alimentary pharmacology & therapeutics

authors： Diederen K,Hoekman DR,Hummel TZ,de Meij TG,Koot BG,Tabbers MM,Vlieger AM,Kindermann A,Benninga MA

更新日期：2016-07-01 00:00:00

abstract：AIM:To compare lansoprazole 30 mg daily with ranitidine 150 mg b.d. in the treatment of acid-related dyspepsia in general practice. METHODS:In a double-blind, parallel group, randomized, mutlicentre study conducted in 32 general practices in the UK, 213 patients were randomized to receive lansoprazole 30 mg daily, and...

journal_title：Alimentary pharmacology & therapeutics

authors： Jones RH,Baxter G

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:The association between ulcerative colitis and cytomegalovirus (CMV) has been recognised for over 50 years; and the role of CMV in ulcerative colitis in general, and steroid resistance in particular, remains a topic of ongoing controversy. The outcome for patients with CMV reactivation appears worse than tha...

journal_title：Alimentary pharmacology & therapeutics

authors： Sager K,Alam S,Bond A,Chinnappan L,Probert CS

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Benign epithelial gastric polyps have been reported to be more common in atrophic body gastritis. The role of Helicobacter pylori infection in the induction of gastric atrophy is well-known. The development of hyperplastic polyps may be in relation to H. pylori infection. AIM:To investigate occurrence of be...

journal_title：Alimentary pharmacology & therapeutics

authors： Di Giulio E,Lahner E,Micheletti A,Milione M,D'Ambra G,Bordi C,Delle Fave G,Annibale B

更新日期：2005-03-01 00:00:00

abstract：:Unfractioned heparin was recently reported to be beneficial in the treatment of inflammatory bowel disease. The available uncontrolled data show that it may be effective in steroid-resistant ulcerative colitis with a percentage of complete clinical remission of over 70% after an average of 4-6 weeks of therapy. The ad...

journal_title：Alimentary pharmacology & therapeutics

authors： Papa A,Danese S,Gasbarrini A,Gasbarrini G

更新日期：2000-11-01 00:00:00

abstract：:The cotton top tamarin is a unique model of human ulcerative colitis. This disease is clinically and histologically similar. It is also complicated in some cases by colon cancer. The cotton top tamarin provides an appropriate animal model for assessing new treatments in inflammatory bowel disease. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Warren BF

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Anti-ulcer agents exert various functional effects on gastric epithelial cells. AIM:The effects of a novel gastro-cytoprotective agent (rebamipide) on epithelial restoration following bile acid damage were assessed using primary cultured rabbit gastric epithelial cells. METHODS:Rebamipide was added to comp...

journal_title：Alimentary pharmacology & therapeutics

authors： Watanabe S,Wang XE,Hirose M,Yoshizawa T,Iwazaki R,Oide H,Kitamura T,Miwa H,Miyazaki A,Sato N

更新日期：1996-12-01 00:00:00

abstract：:Ranitidine hydrochloride, a histamine H2-receptor antagonist, was intravenously administered to 61 pregnant women at a dose of 50 mg as premedication for caesarean section; its effects on gastric secretion were studied in the mother and the newborn. The volume of the maternal gastric juice collected immediately after ...

journal_title：Alimentary pharmacology & therapeutics

authors： Ikenoue T,Iito J,Matsuda Y,Hokanishi H

更新日期：1991-06-01 00:00:00

abstract：:The present study examined whether histamine could affect the growth of the enterochromaffin-like (ECL) cell and the parietal cell. The effects of the unsurmountable histamine H2-receptor antagonist loxtidine (80 mg/kg) and the H+, K(+)-ATPase inhibitor omeprazole (100 mumol/kg) were compared in female Sprague-Dawley ...

journal_title：Alimentary pharmacology & therapeutics

authors： Brenna E,Waldum HL,Sandvik AK,Schulze Søgnen B,Kristensen A

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Transjugular intrahepatic portosystemic stent shunts (TIPSS) have been used successfully to reduce portal pressure in the context of variceal haemorrhage. Recent interest has focused on the possible use of TIPSS to manage refractory ascites. AIM:To study the effect of TIPSS insertion in 18 patients with ref...

journal_title：Alimentary pharmacology & therapeutics

authors： Forrest EH,Stanley AJ,Redhead DN,McGilchrist AJ,Hayes PC

更新日期：1996-10-01 00:00:00

abstract：AIM:To determine factors affecting compliance of a follow-up colonoscopy in patients with previously diagnosed adenomatous colon polyps. METHODS:A retrospective review was performed on patients with adenomatous polyps excised between January and December 1998. Twenty-nine clinical factors were assessed in patients gro...

journal_title：Alimentary pharmacology & therapeutics

authors： Siddiqui AA,Patel A,Huerta S

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Although incrimination of the intestinal microbiota in the pathogenesis of IBD is widely accepted, few data are available about the role of specific bacteria. Potentially, Faecalibacterium prausnitzii, bacteria with anti-inflammatory properties, might be deficient in ulcerative colitis (UC). AIM:To quantify...

journal_title：Alimentary pharmacology & therapeutics

authors： Varela E,Manichanh C,Gallart M,Torrejón A,Borruel N,Casellas F,Guarner F,Antolin M

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Two studies were carried out in order to investigate the issue of meal-provoked nocturnal gastrooesophageal reflux. METHODS:In Experiment 1, 20 symptomatic reflux patients underwent both pH and polysomnographic monitoring on two nights. On one night, patients ate a non-provocative meal prior to 19.00 hours,...

journal_title：Alimentary pharmacology & therapeutics

authors： Orr WC,Harnish MJ

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:There is no consensus on the standard treatment of gastric mucosa-associated lymphoid tissue (MALT) lymphoma for Helicobacter pylori-negative patients and for patients with persistent disease despite H. pylori eradication. AIM:To evaluate the comparative efficacy and safety of alkylating agents and rituxima...

journal_title：Alimentary pharmacology & therapeutics

authors： Amiot A,Lévy M,Copie-Bergman C,Dupuis J,Szablewski V,Le Baleur Y,Baia M,Belhadj K,Sobhani I,Leroy K,Haioun C,Delchier JC

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Cross-sectional studies suggest insulin resistance is strongly associated with hepatic steatosis and fibrosis in patients with chronic hepatitis C (CHC), which might affect the efficacy of antiviral therapy. Aim To investigate retrospectively the impact of insulin resistance on treatment response in Chinese ...

journal_title：Alimentary pharmacology & therapeutics

authors： Chu CJ,Lee SD,Hung TH,Lin HC,Hwang SJ,Lee FY,Lu RH,Yu MI,Chang CY,Yang PL,Lee CY,Chang FY

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The mechanism of hypergastrinaemia during omeprazole therapy is unclear, but is generally assumed to be entirely a consequence of acid suppression. However, direct stimulation of G cells by omeprazole could also be a factor. In order to further investigate the mechanism of omeprazole-induced hypergastrinaemi...

journal_title：Alimentary pharmacology & therapeutics

authors： Banerjee S,Ardill JE,Beattie AD,McColl KE

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Ursodeoxycholic acid (UDCA) prolongs transplantation-free survival in primary biliary cirrhosis (PBC). However, the optimal therapeutic dose has not been established. AIM:To compare the effects of UDCA administered in daily doses of 10 vs. 20 mg/kg on symptoms, liver biochemistry and biliary UDCA enrichment...

journal_title：Alimentary pharmacology & therapeutics

authors： Van Hoogstraten HJ,De Smet MB,Renooij W,Breed JG,Engels LG,Den Ouden-Muller JW,Rijk MC,Smit AM,Zwertbroek R,Hop WC,van Berge Henegouwen GP,Schalm SW,van Buuren HR

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:The efficacy of many pharmacological agents for preventing post-ERCP pancreatitis (PEP) has been evaluated in randomised controlled trials (RCTs), but it is unclear which agent(s) should be used in clinical practice. Network meta-analyses of RCTs are used to simultaneously compare several agents to determine...

journal_title：Alimentary pharmacology & therapeutics

authors： Akshintala VS,Hutfless SM,Colantuoni E,Kim KJ,Khashab MA,Li T,Elmunzer BJ,Puhan MA,Sinha A,Kamal A,Lennon AM,Okolo PI,Palakurthy MK,Kalloo AN,Singh VK

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Morphological, haemodynamic and clinical stages of cirrhosis have been proposed, although no definite staging system is yet accepted for clinical practice. AIM:To investigate whether clinical complications of cirrhosis may define different prognostic disease stages. METHODS:Analysis of the database from a ...

journal_title：Alimentary pharmacology & therapeutics

authors： D'Amico G,Pasta L,Morabito A,D'Amico M,Caltagirone M,Malizia G,Tinè F,Giannuoli G,Traina M,Vizzini G,Politi F,Luca A,Virdone R,Licata A,Pagliaro L

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:It is unclear whether adherence to prescribing standards has been achieved in inflammatory bowel disease (IBD). AIM:To determine how prescribing of 5-aminosalicylates (5-ASAs), steroids and thiopurines has changed in response to emerging evidence. METHODS:We examined trends in oral and topical therapies in...

journal_title：Alimentary pharmacology & therapeutics

authors： Chhaya V,Saxena S,Cecil E,Subramanian V,Curcin V,Majeed A,Pollok RC

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:For patients with UC, flexible maintenance dosing therapy may confer advantages for safety, efficacy, costs and patient preference. Tofacitinib is an oral, small molecule JAK inhibitor for the treatment of UC. AIM:To assess the efficacy and safety of tofacitinib dose de-escalation and escalation in patients...

journal_title：Alimentary pharmacology & therapeutics

authors： Sands BE,Armuzzi A,Marshall JK,Lindsay JO,Sandborn WJ,Danese S,Panés J,Bressler B,Colombel JF,Lawendy N,Maller E,Zhang H,Chan G,Salese L,Tsilkos K,Marren A,Su C

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The reflux disease questionnaire (RDQ) is a short, patient-completed instrument. AIMS:To investigate the psychometric characteristics of the RDQ in patients with heartburn-predominant (HB) and non-heartburn predominant (NHB) dyspepsia. METHODS:HB (n = 388) and NHB (n = 733) patients were randomized to esom...

journal_title：Alimentary pharmacology & therapeutics

authors： van Zanten SV,Armstrong D,Barkun A,Junghard O,White RJ,Wiklund IK

更新日期：2007-05-01 00:00:00

abstract：:Thirteen patients with Zollinger-Ellison syndrome were investigated: 8 without, and 5 with, previous gastric surgery. After 7-34 months of treatment with famotidine, 8 out of 13 patients were resistant to this drug. Omeprazole 60 mg/day was administered to these 8 patients; after one month, the dose was reduced to 40 ...

journal_title：Alimentary pharmacology & therapeutics

authors： Corleto V,Annibale B,D'Ambra G,Saggioro A,Ferrua B,Cassetta MR,Delle Fave G

更新日期：1993-04-01 00:00:00

abstract：AIM:To evaluate and compare two 1-week low-dose triple therapies based on lansoprazole, amoxycillin and a macrolide in eradicating Helicobacter pylori. METHODS:Seventy consecutive patients, suffering from dyspeptic symptoms with H. pylori infection, were randomly allocated to one of two treatment groups: (A) (LAC; n =...

journal_title：Alimentary pharmacology & therapeutics

authors： Cammarota G,Tursi A,Papa A,Montalto M,Veneto G,Cuoco L,Fedeli G,Gasbarrini G

更新日期：1996-12-01 00:00:00