Cytokines in the cotton top tamarin model of human ulcerative colitis.

abstract：BACKGROUND:In patients with chronic hepatitis C virus infection and persistently normal alanine aminotransferase levels, liver fibrosis has been reported in 0-22% of cases and advanced liver disease in 5-10% of cases. AIM:To determine whether patients with persistently normal alanine aminotransferase levels clear infe...

journal_title：Alimentary pharmacology & therapeutics

authors： Mangia A,Spinzi G,Vuturo O,Pazienza V,Iacobellis A,Piattelli M,Giacobbe A,Leandro G,Piermanni V,Minoli G,Montalto G,Andriulli A

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis with diverticulosis (UCD), segmental colitis associated with diverticulosis (SCAD) and acute uncomplicated diverticulitis (AUD) may affect the same colonic regions, but the real incidence of these entities in clinical practice is unknown. AIM:To assess the incidence and the endoscopic fin...

journal_title：Alimentary pharmacology & therapeutics

authors： Tursi A,Elisei W,Giorgetti GM,Aiello F,Brandimarte G

更新日期：2011-02-01 00:00:00

abstract：AIM:To compare cheaper and simpler once-daily regimens, with and without a proton pump inhibitor, with standard, twice-daily, triple therapy. METHODS:A randomized, placebo-controlled, treatment trial in Vietnam allocated 296 Helicobacter pylori-infected patients with peptic ulcer of >or= 5 mm to one of three regimens:...

journal_title：Alimentary pharmacology & therapeutics

authors： Wheeldon TU,Hoang TT,Phung DC,Björkman A,Granström M,Sörberg M

更新日期：2003-07-01 00:00:00

abstract：:The United Network for Organ Sharing database revealed that over the last 4-5 years, an average of 1800 patients were removed from the cadaveric waiting list annually because of patients' death and an additional 400-500 were removed from the list because of the severity of their illnesses. The pre-transplant evaluatio...

journal_title：Alimentary pharmacology & therapeutics

authors： Pham PT,Pham PC,Rastogi A,Wilkinson AH

更新日期：2005-04-15 00:00:00

abstract：BACKGROUND:Delayed gastric emptying, impaired gastric accommodation to a meal and hypersensitivity to gastric distension have been implied in the pathophysiology of functional dyspepsia. Dyspeptic patients are often treated with the prokinetic drug cisapride. AIM:To assess the effects of cisapride on perception of gas...

journal_title：Alimentary pharmacology & therapeutics

authors： Tack J,Broeckaert D,Coulie B,Janssens J

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Choosing the optimum pancreatic enzyme replacement therapy for patients with exocrine insufficiency remains a problem. An enteric coated enzyme microsphere pancreatic enzyme preparation (Pancrease) has been marketed with several levels of lipase activity, implying that there is a dose-response relationship b...

journal_title：Alimentary pharmacology & therapeutics

authors： Opekun AR Jr,Sutton FM Jr,Graham DY

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Microscopic colitis (MC) is a common chronic diarrhoeal disease, and remission can be induced with budesonide. However, diarrhoea relapses frequently when budesonide is tapered and a few patients become budesonide intolerant. AIM:To examine retrospectively the effect of azathioprine (AZA) and mercaptopurine...

journal_title：Alimentary pharmacology & therapeutics

authors： Münch A,Fernandez-Banares F,Munck LK

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Gut microflora-mucosal interactions may be involved in the pathogenesis of irritable bowel syndrome (IBS). AIM:To investigate the efficacy of a novel prebiotic trans-galactooligosaccharide in changing the colonic microflora and improve the symptoms in IBS sufferers. METHODS:In all, 44 patients with Rome II...

journal_title：Alimentary pharmacology & therapeutics

authors： Silk DB,Davis A,Vulevic J,Tzortzis G,Gibson GR

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Renewed interest in the use of antibiotics to prevent travellers' diarrhoea has occurred with the availability of non-absorbed (<0.4%) rifaximin, and with evidence that a subgroup of travellers with diarrhoea have progression of their illnesses to postinfectious irritable bowel syndrome. AIM:To summarize re...

journal_title：Alimentary pharmacology & therapeutics

authors： DuPont HL

更新日期：2008-05-01 00:00:00

abstract：:We report a patient who developed sulphasalazine-related hepatitis with a subsequent adverse reaction to rectal 5-amino salicylic acid, in the form of pain and fever without associated liver dysfunction, suggesting reactions to both components of sulphasalazine. Included is a review of the literature. Caution should b...

journal_title：Alimentary pharmacology & therapeutics

authors： Burke DA,Manning AP,Williamson JM,Axon AT

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Irritable bowel syndrome is characterised by chronic abdominal pain and frequent comorbid anxiety. The substance P ⁄ neurokinin-1 receptor system is implicated in the regulation of both pain and anxiety, suggesting a potential therapeutic target in IBS. AIM:To determine whether inhibition of the neurokinin-...

journal_title：Alimentary pharmacology & therapeutics

authors： Tillisch K,Labus J,Nam B,Bueller J,Smith S,Suyenobu B,Siffert J,McKelvy J,Naliboff B,Mayer E

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Practitioners routinely misuse acid suppression medications on general medical floors and inappropriately continue the drug at discharge. AIMS:To: (i) retrospectively study the appropriateness of acid suppression use on the general medical floors; (ii) characterize the patient population discharged on unnec...

journal_title：Alimentary pharmacology & therapeutics

authors： Zink DA,Pohlman M,Barnes M,Cannon ME

更新日期：2005-05-15 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is characterised by intense mucosal recruitment of activated leukocytes. Chemokines determine inflammatory leukocyte recruitment and retention. AIM:To compare expression of the entire chemokine family within colonic mucosa from IBD patients and uninflamed controls. METHODS:...

journal_title：Alimentary pharmacology & therapeutics

authors： Puleston J,Cooper M,Murch S,Bid K,Makh S,Ashwood P,Bingham AH,Green H,Moss P,Dhillon A,Morris R,Strobel S,Gelinas R,Pounder RE,Platt A

更新日期：2005-01-15 00:00:00

abstract：BACKGROUND:A novel potassium-competitive acid blocker, DWP14012, is in clinical development as a potential alternative to proton pump inhibitors for the treatment of acid-related diseases. AIMS:To evaluate the safety, tolerability, pharmacodynamics and pharmacokinetics of DWP14012 in humans. METHODS:A randomised, dou...

journal_title：Alimentary pharmacology & therapeutics

authors： Sunwoo J,Oh J,Moon SJ,Ji SC,Lee SH,Yu KS,Kim HS,Lee A,Jang IJ

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Lubiprostone (8 μg b.d.) received US Food and Drug Administration (FDA) approval in 2008 for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) in women aged ≥18 years. In 2012, the FDA issued new guidance for IBS-C clinical trials, recommending a composite endpoint incorporating both...

journal_title：Alimentary pharmacology & therapeutics

authors： Chang L,Chey WD,Drossman D,Losch-Beridon T,Wang M,Lichtlen P,Mareya S

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Studies to date have not directly compared the pharmacodynamic efficacies of different proton pump inhibitors in controlling intragastric acidity in patients treated with non-steroidal anti-inflammatory drugs. AIM:To compare acid suppression with once-daily esomeprazole 40 mg, lansoprazole 30 mg and pantopr...

journal_title：Alimentary pharmacology & therapeutics

authors： Goldstein JL,Miner PB Jr,Schlesinger PK,Liu S,Silberg DG

更新日期：2006-04-15 00:00:00

abstract：:There is some evidence from clinical, experimental and multiprobe ambulatory pH studies that gastro-oesophageal reflux is more common in patients with laryngeal symptoms and could potentially play a role in the causation of these symptoms. The proportion of unselected patients with laryngeal symptoms who have gastro-o...

journal_title：Alimentary pharmacology & therapeutics

authors： Fraser AG

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:No prognostic tools are established for alcohol-related liver disease (ALD). Collagen proportionate area (CPA) measurement is a technique that quantifies fibrous tissue in liver biopsies using digital image analysis. AIM:To assess the predictive value of CPA on hepatic decompensation and liver-related morta...

journal_title：Alimentary pharmacology & therapeutics

authors： Israelsen M,Guerrero Misas M,Koutsoumourakis A,Huang Y,Thiele M,Hall A,Rasmussen D,Covelli C,Buzzetti E,Prat LI,Roccarina D,Detlefsen S,Luong TV,Quaglia A,Krag A,Jeffrey G,Pinzani M,Tsochatzis EA

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:The large (n = 18 325) Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET) study demonstrated a significant gastrointestinal benefit with lumiracoxib 400 mg o.d. (4x the recommended dose in osteoarthritis) vs. naproxen 500 mg b.d. or ibuprofen 800 mg t.d.s. AIM:To investigate how early ...

journal_title：Alimentary pharmacology & therapeutics

authors： Hawkey CJ,Weinstein WM,Stricker K,Murphy V,Richard D,Krammer G,Rebuli R

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:The disease severity of non-alcoholic fatty liver disease (NAFLD) and the distinction between simple steatosis and non-alcoholic steatohepatitis (NASH) are based on the pathohistological presence of steatosis, inflammation, ballooning and fibrosis. However, little is known about the relation between such str...

journal_title：Alimentary pharmacology & therapeutics

authors： Eriksen PL,Thomsen KL,Larsen LP,Grønbaek H,Vilstrup H,Sørensen M

更新日期：2019-07-01 00:00:00

abstract：:Visceral hypersensitivity is highly prevalent in all functional bowel disorders. Most also demonstrate wider patterns of somatic referral of intestinal pain or discomfort. This hypersensitivity may explain the symptoms as the sensitive gut can be more easily provoked by normal or abnormal motor events in the gut. Visc...

journal_title：Alimentary pharmacology & therapeutics

authors： Mertz H

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Epidemiological studies of microscopic colitis have shown varying but increasing incidence rates. AIM:To assess the incidence of microscopic colitis in Sweden. METHODS:Nationwide cohort study performed in 1995-2015 based on biopsy reports. Age-specific and age-standardised incidence rates were calculated. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Bergman D,Clements MS,Khalili H,Agréus L,Hultcrantz R,Ludvigsson JF

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD) has a high-risk of bowel resection and later surgery for recurrent disease. Recent guidelines recommend colonoscopy 6-12 months following surgery to reduce further surgical intervention through medical therapy intensification. AIMS:To investigate the risk of further surgery at the anast...

journal_title：Alimentary pharmacology & therapeutics

authors： King D,Coupland B,Dosanjh A,Cole A,Adderley NJ,Reulen RC,Patel P,Trudgill NJ

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Helicobacter-negative gastritis and duodenitis occur more often in patients with inflammatory bowel disease (IBD) than in non-IBD controls. Preliminary evidence suggests that they are particularly common among children. AIM:To study the age-specific occurrence of gastritis and duodenitis among paediatric IB...

journal_title：Alimentary pharmacology & therapeutics

authors： Genta RM,Sonnenberg A

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Regulatory requirements for claims of mucosal healing in ulcerative colitis (UC) will require demonstration of both endoscopic and histologic healing. Quantifying these rates is essential for future drug development. AIMS:To meta-analyse endoscopic and histologic placebo response and remission rates in UC r...

journal_title：Alimentary pharmacology & therapeutics

authors： Ma C,Guizzetti L,Panaccione R,Fedorak RN,Pai RK,Parker CE,Nguyen TM,Khanna R,Vande Casteele N,D'Haens G,Sandborn WJ,Feagan BG,Jairath V

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Differentiating symptoms of irritable bowel syndrome from those of organic intestinal disease is a common clinical problem. Several neutrophil-derived proteins have been proposed as a marker of inflammatory bowel disease. AIM:To compare the diagnostic value of faecal calprotectin, lactoferrin and polymorpho...

journal_title：Alimentary pharmacology & therapeutics

authors： Schröder O,Naumann M,Shastri Y,Povse N,Stein J

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Irritable bowel syndrome is the most common diagnosis in gastroenterology. Trials suggest certain probiotics to be beneficial. AIM:To investigate the effects of multispecies probiotic supplementation (Lactobacillus rhamnosus GG, L. rhamnosus Lc705, Propionibacterium freudenreichii ssp. shermanii JS and Bifi...

journal_title：Alimentary pharmacology & therapeutics

authors： Kajander K,Myllyluoma E,Rajilić-Stojanović M,Kyrönpalo S,Rasmussen M,Järvenpää S,Zoetendal EG,de Vos WM,Vapaatalo H,Korpela R

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Ingestion of capsaicin reduces symptoms in functional dyspepsia but induces upper abdominal symptoms initially. AIMS:To evaluate the effects of one week of oral dosing with capsaicin on mechanonociception and chemonociception. METHODS:Healthy subjects ingested capsules containing 0.5 mg capsaicin t.d.s (n ...

journal_title：Alimentary pharmacology & therapeutics

authors： Hammer J

更新日期：2006-08-15 00:00:00

abstract：BACKGROUND:Much recent effort has been made to produce selective inhibitors of cyclo-oxygenase-2 (COX-2) in the belief that these will lack the gastrointestinal damaging effects of traditional non-steroidal anti-inflammatory drugs (NSAIDs). Inflammatory bowel disease is associated with increased local production of pro...

journal_title：Alimentary pharmacology & therapeutics

authors： McCartney SA,Mitchell JA,Fairclough PD,Farthing MJ,Warner TD

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori eradication has become the standard treatment for duodenal ulcer. However, there is no relevant evidence for antibacterial treatment of the white scar stage of duodenal ulcer (duodenal ulcer scar) in patients with no past history of duodenal ulcer. AIM:To investigate whether H. pylori er...

journal_title：Alimentary pharmacology & therapeutics

authors： Kim JS,Kim SG,Choi IJ,Park MJ,Kim BG,Jung HC,Song IS

更新日期：2002-02-01 00:00:00