Review article: 'true' re-infection of Helicobacter pylori after successful eradication--worldwide annual rates, risk factors and clinical implications.


BACKGROUND:The incidence of 'true' re-infection with Helicobacter pylori after successful eradication remains uncertain. AIM:To determine the worldwide rates, risk factors and clinical implications of 'true' re-infection of Helicobacter pylori. 'True' re-infection of H. pylori is defined as the situation where tests for H. pylori infection, which were negative for 12 months after eradication, become positive again at a later stage. RESULTS:Thirty six studies were identified through a literature search to be able to produce annual rates of 'true' re-infection, and data from 33 original articles were considered reliable and adequate in the further review. Generally, the reported rates varied from 0% to 23.4% in adults and from 1.9% to 9.6% in children. Most studies from developed countries reported rates of less than 1%, whereas relatively higher rates were reported in most of the developing countries. Small sample sizes included in the studies appeared to be associated with increased re-infection rates. Interfamilial transmission is the major cause of re-infection, although iatrogenic re-infection through contaminated endoscopic equipment has been reported. CONCLUSION:Helicobacter pylori re-infection is not a concern in a clinical setting, especially in the developed world; however, caution must be exercised in most developing countries.


Aliment Pharmacol Ther


Zhang YY,Xia HH,Zhuang ZH,Zhong J




Has Abstract


2009-01-01 00:00:00














  • Efficacy of a standard United Kingdom oral rehydration solution (ORS) and a hypotonic ORS assessed by human intestinal perfusion.

    abstract::Human triple-lumen intestinal perfusion was used to compare water and solute absorption from the oral rehydration solution (ORS) most widely used in the United Kingdom and a new experimental hypotonic ORS (HYPO-ORS). HYPO-ORS (osmolality 210 mOsm/kg) promoted significantly greater water absorption than UK-ORS (7.03 +/...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Hunt JB,Elliott EJ,Farthing MJ

    更新日期:1989-12-01 00:00:00

  • Prediction of Crohn's disease relapse with faecal calprotectin in infliximab responders: a prospective study.

    abstract:BACKGROUND:Faecal calprotectin is a reliable tool for predicting Crohn's disease (CD) relapse in patients with sustained remission. Prediction of relapse with faecal calprotectin has been less studied in patients with severe CD treated with anti-TNF. AIM:To identify an association between faecal calprotectin concentra...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Laharie D,Mesli S,El Hajbi F,Chabrun E,Chanteloup E,Capdepont M,Razaire S,de Lédinghen V,Zerbib F

    更新日期:2011-08-01 00:00:00

  • Increasing comorbidities in a South Korea insured population-based cohort of patients with chronic hepatitis B.

    abstract:BACKGROUND:It is controversial whether chronic hepatitis B (CHB) patients have more non-liver comorbidities than non-CHB subjects. AIM:To characterise the demographics, comorbidity and health utilisation of CHB patients in South Korea and compare them to matched controls. METHODS:Using the Health Insurance Review & A...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Oh H,Jun DW,Lee IH,Ahn HJ,Kim BO,Jung S,Nguyen MH

    更新日期:2020-07-01 00:00:00

  • Clinical predictors of small intestinal bacterial overgrowth by duodenal aspirate culture.

    abstract:BACKGROUND:There has been increasing interest in small intestinal bacterial overgrowth (SIBO) after reports of a link with irritable bowel syndrome (IBS), yet our understanding of this entity is limited. AIM:Our aim was to estimate the yield of patients undergoing duodenal aspirate culture, and to identify symptoms an...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Choung RS,Ruff KC,Malhotra A,Herrick L,Locke GR 3rd,Harmsen WS,Zinsmeister AR,Talley NJ,Saito YA

    更新日期:2011-05-01 00:00:00

  • Review article: visceral hypersensitivity.

    abstract::Visceral hypersensitivity is highly prevalent in all functional bowel disorders. Most also demonstrate wider patterns of somatic referral of intestinal pain or discomfort. This hypersensitivity may explain the symptoms as the sensitive gut can be more easily provoked by normal or abnormal motor events in the gut. Visc...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Mertz H

    更新日期:2003-03-01 00:00:00

  • Clinical trial: the incidence and early mortality after peptic ulcer perforation, and the use of low-dose aspirin and nonsteroidal anti-inflammatory drugs.

    abstract:BACKGROUND:It is not clear whether the incidence or early mortality related to peptic ulcer perforation has changed. AIM:To evaluate the incidence and mortality related to peptic ulcer perforation while considering the intake of low-dose aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs). METHODS:We recorded t...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Taha AS,Angerson WJ,Prasad R,McCloskey C,Gilmour D,Morran CG

    更新日期:2008-10-01 00:00:00

  • Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome.

    abstract:AIM:To update previous overviews of placebo-controlled double-blind trials assessing the efficacy and tolerance of smooth muscle relaxants in irritable bowel syndrome. METHODS AND TRIALS: A total of 23 randomized clinical trials were selected for meta-analyses of their efficacy and tolerance. Six drugs were analysed: c...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,meta分析


    authors: Poynard T,Regimbeau C,Benhamou Y

    更新日期:2001-03-01 00:00:00

  • Usefulness of a delayed test for the diagnosis of Helicobacter pylori infection in bleeding peptic ulcer.

    abstract:AIM:To evaluate (i) the diagnostic usefulness of a delayed test in initially negative patients; and (ii) the reliability of the rapid urease test, histology or a combination of the two to diagnose Helicobacter pylori during emergency endoscopy in a large clinical practice series. PATIENTS AND METHODS:Records of patien...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Güell M,Artigau E,Esteve V,Sánchez-Delgado J,Junquera F,Calvet X

    更新日期:2006-01-01 00:00:00

  • Sleep-related gastro-oesophageal reflux: provocation with a late evening meal and treatment with acid suppression.

    abstract:BACKGROUND:Two studies were carried out in order to investigate the issue of meal-provoked nocturnal gastrooesophageal reflux. METHODS:In Experiment 1, 20 symptomatic reflux patients underwent both pH and polysomnographic monitoring on two nights. On one night, patients ate a non-provocative meal prior to 19.00 hours,...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章


    authors: Orr WC,Harnish MJ

    更新日期:1998-10-01 00:00:00

  • Review article: platelets in inflammatory bowel disease--pathogenetic role and therapeutic implications.

    abstract::An elevated platelet count is well recognized as a marker of inflammatory bowel disease activity. There is an increased incidence of systemic thromboembolism in this disease. Recent work indicates that platelets exhibit several proinflammatory properties including release of inflammatory mediators, and recruitment, ch...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Collins CE,Rampton DS

    更新日期:1997-04-01 00:00:00

  • Prospective study of the need for long-term antisecretory therapy in patients with Zollinger-Ellison syndrome following successful curative gastrinoma resection.

    abstract::A long-term cure is now possible in more than 30% of selected patients with Zollinger-Ellison syndrome who undergo gastrinoma resection. The need, however, for continued gastric acid antisecretory therapy in these patients remains controversial. The current study was designed to determine whether post-operative antise...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Metz DC,Benya RV,Fishbeyn VA,Pisegna JR,Orbuch M,Strader DB,Norton JA,Jensen RT

    更新日期:1993-06-01 00:00:00

  • Determinants of long-term outcome in severe alcoholic hepatitis.

    abstract:BACKGROUND:Although short-term outcome in severe alcoholic hepatitis (SAH) is well described, its long-term course remains uncharacterised. AIM:To assess determinants of long-term outcome in SAH. METHODS:Data were recorded from a cohort with SAH (admission Discriminant Function (DF) ≥32). Kaplan-Meier (KM) and Cox pr...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Potts JR,Goubet S,Heneghan MA,Verma S

    更新日期:2013-09-01 00:00:00

  • Efficacy of two one-week rabeprazole/levofloxacin-based triple therapies for Helicobacter pylori infection.

    abstract:BACKGROUND:One-week low-dose proton pump inhibitor-based triple therapies have usually proved to be effective treatments for Helicobacter pylori infection. AIM:To investigate the eradication efficacy, safety profile and patient compliance of two triple therapies containing a standard dose of rabeprazole and a new fluo...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章


    authors: Cammarota G,Cianci R,Cannizzaro O,Cuoco L,Pirozzi G,Gasbarrini A,Armuzzi A,Zocco MA,Santarelli L,Arancio F,Gasbarrini G

    更新日期:2000-10-01 00:00:00

  • Colonic delivery of 4-aminosalicylic acid using amylose-ethylcellulose-coated hydroxypropylmethylcellulose capsules.

    abstract:BACKGROUND:4-Aminosalicylic acid has the potential for use in the treatment of diseases of the colon. AIM:To assess the feasibility of delivering 4-aminosalicylic acid directly to the colon using a hydroxypropylmethylcellulose capsule coated with a mixture of amylose, a polysaccharide metabolized by bacterial enzymes ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Tuleu C,Basit AW,Waddington WA,Ell PJ,Newton JM

    更新日期:2002-10-01 00:00:00

  • Earlier discontinuation of TNF-α inhibitor therapy in female patients with inflammatory bowel disease is related to a greater risk of side effects.

    abstract:BACKGROUND:In rheumatoid arthritis and psoriasis female sex has been shown to be associated with discontinuation of anti-tumour necrosis factor-α (TNF-α) therapy. AIM:To retrospectively assess the association between sex and TNF-α drug persistence in patients with inflammatory bowel disease (IBD). METHODS:All IBD pat...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Schultheiss JPD,Brand EC,Lamers E,van den Berg WCM,van Schaik FDM,Oldenburg B,Fidder HH

    更新日期:2019-08-01 00:00:00

  • The changing incidence of oesophageal and gastric adenocarcinoma by anatomic sub-site.

    abstract:BACKGROUND:The incidence rates of gastric and oesophageal adenocarcinoma are changing significantly, but little is known about specific sub-sites. AIM:To use a population-based approach to describe the trends in the site-specific incidence of oesophageal and gastric adenocarcinoma. METHODS:Using the Rochester Epidemi...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Crane SJ,Richard Locke G 3rd,Harmsen WS,Diehl NN,Zinsmeister AR,Joseph Melton L 3rd,Romero Y,Talley NJ

    更新日期:2007-02-15 00:00:00

  • Anti-viral therapy can be delayed or avoided in a significant proportion of HBeAg-negative Caucasian patients in the Grey Zone.

    abstract:BACKGROUND:Grey Zone (GZ) is an ill-defined situation including patients falling between inactive carrier (IC) state and HBeAg-negative chronic hepatitis B (HBeAg-negative CHB). AIMS:To assess the long-term outcomes of GZ patients compared to IC in the absence of treatment. METHODS:Retrospective analysis of 287 IC an...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Bonacci M,Lens S,Mariño Z,Londoño MC,Rodríguez-Tajes S,Mas A,García-López M,Pérez-Del-Pulgar S,Sánchez-Tapias JM,Forns X

    更新日期:2018-05-01 00:00:00

  • Lack of immunogenicity of hydrolysed wheat flour in patients with coeliac disease after a short-term oral challenge.

    abstract:BACKGROUND:A gluten-free diet is currently the only reliable therapeutic strategy that is approved for coeliac disease (CD). For many patients, however, compliance remains inadequate. AIM:To investigate the immunogenicity of wheat flour that was pre-treated with selected lactobacilli and fungal proteases (hydrolysed w...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,随机对照试验


    authors: Mandile R,Picascia S,Parrella C,Camarca A,Gobbetti M,Greco L,Troncone R,Gianfrani C,Auricchio R

    更新日期:2017-08-01 00:00:00

  • What is the role of serology in assessing Helicobacter pylori eradication?

    abstract:AIM:To assess the decline in Helicobacter pylori antibodies after eradication of infection. METHODS:The H. pylori status was determined at entry (D0) by culture and histology performed on antral biopsies and after eradication treatment at day 42 (day 42) and after 6 months (M6) by the 13C-urea breath test. The EIA kit...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bergey B,Marchildon P,Peacock J,Mégraud F

    更新日期:2003-09-15 00:00:00

  • A comparison between enprostil and ranitidine in the management of gastric ulceration.

    abstract::In a randomly allocated, double-blind, endoscopically controlled study, 98 patients with gastric ulcers were treated with either (a synthetic prostaglandin of E2-like structure) enprostil 70 micrograms b.d. or 150 mg ranitidine b.d. The healing rates at 4, 8 and 12 weeks were enprostil 57, 91 and 94% and for ranitidin...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Morgan AG,Pacsoo C,Taylor P,McAdam WA

    更新日期:1990-12-01 00:00:00

  • The importance of clarithromycin dose in the management of Helicobacter pylori infection: a meta-analysis of triple therapies with a proton pump inhibitor, clarithromycin and amoxycillin or metronidazole.

    abstract:BACKGROUND:It is not clear which dose of clarithromycin (500 mg b.d. or 250 mg b.d.) is more effective for Helicobacter pylori eradication in proton pump inhibitor-based triple therapies. METHODS:We undertook a meta-analysis of the effect of 7-day triple therapies consisting of a proton pump inhibitor (P), and clarith...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,meta分析


    authors: Huang J,Hunt RH

    更新日期:1999-06-01 00:00:00

  • Effect of pepper and bismuth subsalicylate on gastric pain and surface hydrophobicity in the rat.

    abstract:BACKGROUND:The mechanism by which dietary pepper causes dyspepsia and epigastric pain is poorly understood, as is the ability of bismuth subsalicylate (BSS) to relieve these symptoms. AIM:To investigate the ability of black pepper, red pepper and BSS to affect gastric surface hydrophobicity and induce/relieve visceral...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Lichtenberger LM,Romero JJ,Carryl OR,Illich PA,Walters ET

    更新日期:1998-05-01 00:00:00

  • Prospective evaluation of faecal neutrophil-derived proteins in identifying intestinal inflammation: combination of parameters does not improve diagnostic accuracy of calprotectin.

    abstract:BACKGROUND:Differentiating symptoms of irritable bowel syndrome from those of organic intestinal disease is a common clinical problem. Several neutrophil-derived proteins have been proposed as a marker of inflammatory bowel disease. AIM:To compare the diagnostic value of faecal calprotectin, lactoferrin and polymorpho...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Schröder O,Naumann M,Shastri Y,Povse N,Stein J

    更新日期:2007-10-01 00:00:00

  • Apoptosis and proliferation in Helicobacter pylori-associated gastric intestinal metaplasia.

    abstract:BACKGROUND:Imbalance between apoptosis and proliferation may be one of the mechanisms underlying H. pylori associated gastric carcinogenesis. AIM:To examine the cell kinetics of gastric intestinal metaplasia and the effect of H. pylori eradication. METHODS:Endoscopic gastric biopsies were obtained from 100 H. pylori-...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Leung WK,Yu J,To KF,Go MY,Ma PK,Chan FK,Sung JJ

    更新日期:2001-09-01 00:00:00

  • Obesity is independently associated with infection in hospitalised patients with end-stage liver disease.

    abstract:BACKGROUND:Infection is the most common cause of mortality in end-stage liver disease (ESLD). The impact of obesity on infection risk in ESLD is not established. AIM:To characterise the impact of obesity on infection risk in ESLD. METHODS:We evaluated the association between infection and obesity in patients with ESL...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Sundaram V,Kaung A,Rajaram A,Lu SC,Tran TT,Nissen NN,Klein AS,Jalan R,Charlton MR,Jeon CY

    更新日期:2015-12-01 00:00:00

  • Incidence, clinical presentation and mortality of liver cirrhosis in Southern Sweden: a 10-year population-based study.

    abstract:BACKGROUND:In Sweden, the most common causes of liver cirrhosis are alcohol overconsumption and hepatitis C. However, recent data on the clinical characteristics of Swedish patients with cirrhosis are scarce. AIMS:To determine the incidence, clinical presentation, aetiological spectrum and survival rates of liver cirr...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Nilsson E,Anderson H,Sargenti K,Lindgren S,Prytz H

    更新日期:2016-06-01 00:00:00

  • Systematic review with meta-analysis: the efficacy and safety of direct-acting antivirals in children and adolescents with chronic hepatitis C virus infection.

    abstract:BACKGROUND:The effect of direct-acting anti-virals (DAAs) in children and adolescents with chronic hepatitis C virus (HCV) infection is difficult to determine, since few, aged between 3 and 18 years, have been enrolled in clinical trials, and some data come from observational studies. AIM:To summarise the evidence on ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,meta分析


    authors: Indolfi G,Giometto S,Serranti D,Bettiol A,Bigagli E,De Masi S,Lucenteforte E

    更新日期:2020-10-01 00:00:00

  • Influence of tegaserod on proximal gastric tone and on the perception of gastric distension.

    abstract:BACKGROUND:Tegaserod, a 5-hydroxytryptamine-4 receptor agonist, enhances gastric emptying, but its effects on proximal stomach function have not been studied. AIM:To study the effect of tegaserod on gastric compliance, accommodation and perception of distension in humans. METHODS:Nineteen healthy volunteers (10 femal...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tack J,Vos R,Janssens J,Salter J,Jauffret S,Vandeplassche G

    更新日期:2003-11-15 00:00:00

  • The use of pancreatic enzyme replacement therapy in patients with a diagnosis of chronic pancreatitis and pancreatic cancer in the US is infrequent and inconsistent.

    abstract:BACKGROUND:Patients with chronic pancreatitis or pancreatic cancer commonly develop exocrine pancreatic insufficiency, and may not be adequately treated with pancreatic enzyme replacement therapy (PERT). AIMS:To estimate the frequency of diagnostic testing for exocrine insufficiency, and appropriate use of PERT, in a ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Forsmark CE,Tang G,Xu H,Tuft M,Hughes SJ,Yadav D

    更新日期:2020-05-01 00:00:00

  • The 12-month safety profile of dexlansoprazole, a proton pump inhibitor with a dual delayed release formulation, in patients with gastro-oesophageal reflux disease.

    abstract:BACKGROUND:Dexlansoprazole MR is a Dual Delayed Release formulation of dexlansoprazole, an enantiomer of lansoprazole, designed to extend the duration of acid suppression. AIM:To assess the 12-month safety of dexlansoprazole MR in patients with symptomatic gastro-oesophageal reflux disease (GERD). METHODS:In this ran...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Dabholkar AH,Han C,Paris MM,Perez MC,Atkinson SN,Peura DA

    更新日期:2011-02-01 00:00:00