Does moxonidine increase cytotoxic activity of ethanol in rats? Preliminary report on the base of the ultrastructural study.

Abstract:

:Combined effects of moxonidine and ethanol on ultrastructure of selected Wistar-Kyoto rat organs (kidney, liver, heart) were investigated. In cells of the animals, which received moxonidine alone, no morphological changes were found. In the group of rats which received alcohol, several typical submicroscopical changes were found, especially related to the mitochondria. After the combined administration of ethanol and moxonidine the pathological changes were bigger than those found in animals which received alcohol alone. Those changes were particularly significant in kidney and liver. The results might indicate that moxonidine increased cytotoxic activity of ethanol on several organs in rats.

authors

Marczewski K,Halliop J,Dziemidok P,Korczak E,Obuchowska-Przebirowska D,Tochman A,Siemionow A

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

241-6

issue

4

eissn

0004-069X

issn

1661-4917

journal_volume

46

pub_type

杂志文章
  • Interferonogenic and antiviral effect of extracts from Erodium cicutarium.

    abstract::Extracts from Erodium cicutarium L. Herit were tested for antiviral and interferon inducing properties. Both water extract and methanol extract as well as its fractions were observed to exert antiviral effect in relation to myxoviruses, Herpes virus type 1, Vesicular stomatitis and vaccinia virus. None of these extrac...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Zielińska-Jenczylik J,Sypuła A,Budko E,Rzadkowska-Bodalska H

    更新日期:1987-01-01 00:00:00

  • Antigenic characterization of urea-extractable crude burn toxin.

    abstract::Crude burn toxin was obtained from human skin scalded for 1 min at 90 degrees C in vitro. The toxin solubilized with 8 M urea was administered to rabbits to obtain antiserum. The antigenic analysis carried out by immunodiffusion and immunoelectrophoresis demonstrated that urea-extractable toxin solution differed from ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Grzybowski J,Bogusławska-Kubin J

    更新日期:1981-01-01 00:00:00

  • A simple colorimetric method for the measurement of phagocytosis of crystals of low molecular weight compound by macrophages.

    abstract::Sodium salt of 9-oxo-10-acridineacetohydroxamic acid (HCA), a new synthetic compound, forms small crystals in aqueous solutions. These crystals were easily phagocytable by the mouse bone marrow-derived macrophages. The ingested HCA crystals were visible under light microscope as dark granules. The counting of cells wi...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Piasecki E,Szulc B,Szulc Z

    更新日期:1988-01-01 00:00:00

  • Effect of benzisoselenazolones and organic diselenides on graft versus host reaction and immunoglobulins levels in chickens.

    abstract::Two week old chickens were treated once daily for 5 days with AE8--1-pyridyl-1,2-benzisoselenazol-3(2H)-one, AE22--bis-2-(N-phenyle-carboxamido) 1 pyridyl diselenide and AE31--bis(phenylo-diselenide with R3 = CONHC18H37). Their whole blood alone or blood mixed with thymus cells were used to generate graft versus host ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Błaszczyk B,Inglot AD,Toivanen P,Młochowski J,Szymaniec S

    更新日期:1995-01-01 00:00:00

  • Macrophage migration inhibitory factor and its role in autoimmune diseases.

    abstract::After several decades of research into the macrophage migration inhibitory factor (MIF), its diverse actions in the immune system are yet to be fully revealed. What has become clear is that MIF plays an important role in both innate and adaptive immunity. However, while several pathways mediating the function of MIF i...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:

    authors: Denkinger CM,Metz C,Fingerle-Rowson G,Denkinger MD,Forsthuber T

    更新日期:2004-11-01 00:00:00

  • Distribution of apolipoprotein E4 isoform in Alzheimer's disease in Poland.

    abstract::Alzheimer's disease (AD) is the most common human progressive dementia linked, in its sporadic form, to a common polymorphism within a gene for apolipoprotein E (APOE) mapped to chromosome 19. Individuals with APOE 4 isoforms are more prone to develop sporadic from of AD than those who carry APOE 2 or APOE 3 alleles. ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Bratosiewicz-Zapart J,Kłoszewska I,Sobów T,Liberski PP

    更新日期:1997-01-01 00:00:00

  • Antiviral signaling through retinoic acid-inducible gene-I-like receptors.

    abstract::The innate immune system is essential for the first line of host defense against micropathogens. In virus-infected cells, exposed viral nucleotides are sensed by pattern recognition receptors (PRRs), resulting in the induction of type I interferon. Retinoic acid-inducible gene-I-like receptors (RLRs) are a member of P...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:10.1007/s00005-010-0107-9

    authors: Matsumiya T,Imaizumi T,Yoshida H,Satoh K

    更新日期:2011-02-01 00:00:00

  • Studies on the human mixed lymphocyte culture. I. The influence of the irradiated autogenic and allogenic lymphocytes on DNA synthesis.

    abstract::Fourteen patients with chronic renal failure and their prospective living donors were examined. DNA uptake by donors' monocultures, recipients' monocultures and mixed cultures was measured. The influence of X-ray treated cells on proliferative capacity of untreated cells in these three types of cultures was studied. T...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Wojtulewicz-Kurkus J,Skopińska E,Nowaczyk M

    更新日期:1978-01-01 00:00:00

  • Is sex worth searching for?

    abstract::Several methods of molecular sexing (i.e. detection of Y-chromosomal sequences) have been briefly presented. In addition to other applications they can be used for monitoring of patients after sex-mismatched bone marrow transplantation for mixed chimerism and for detection of fetal cells in maternal circulation. Clini...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:

    authors: Witt M

    更新日期:1994-01-01 00:00:00

  • Myeloid-Derived Suppressor Cells in the Tumor Microenvironment: Current Knowledge and Future Perspectives.

    abstract::The current knowledge on tumor-infiltrating myeloid-derived suppressor cells (MDSCs) is based mainly on the extensive work performed in murine models. Data obtained for human counterparts are generated on the basis of tumor analysis from patient samples. Both sources of information led to determination of the main sup...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:10.1007/s00005-017-0492-4

    authors: Ibáñez-Vea M,Zuazo M,Gato M,Arasanz H,Fernández-Hinojal G,Escors D,Kochan G

    更新日期:2018-04-01 00:00:00

  • The Impact of Sex and Age on the Prevalence of Clinically Relevant Sensitization and Asymptomatic Sensitization in the General Population.

    abstract::The objective of our study was to evaluate the impact of sex and age on the prevalence of sensitization to inhalant allergens. The study was performed as a part of Polish Epidemiology of Allergic Diseases study, and data concerning citizens of Wroclaw were analyzed. The participants were divided into three age groups ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:10.1007/s00005-016-0425-7

    authors: Dor-Wojnarowska A,Liebhart J,Miecielica J,Rabski M,Fal A,Samoliński B,Nittner-Marszalska M

    更新日期:2017-06-01 00:00:00

  • IL-15 and IL-15Ralpha in CD4+T cell immunity.

    abstract::The cytokine IL-15 performs numerous functions, such as promotion of growth and survival, on a plethora of cell types from both the lymphoid and non-lymphoid compartments. Therefore, mice genetically engineered to either lack or overexpress functional IL-15 display reduced immunological responses and leukemia, respect...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:

    authors: Van Belle T,Grooten J

    更新日期:2005-03-01 00:00:00

  • Immunopathogenic Background of Pars Planitis.

    abstract::Pars planitis is defined as an intermediate uveitis of unknown background of systemic disease with characteristic formations such as vitreous snowballs, snowbanks and changes in peripheral retina. The incidence of pars planitis varies 2.4-15.4 % of the uveitis patients. The pathogenesis of the disease is to be determi...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:10.1007/s00005-015-0361-y

    authors: Przeździecka-Dołyk J,Węgrzyn A,Turno-Kręcicka A,Misiuk-Hojło M

    更新日期:2016-04-01 00:00:00

  • Purification of mammalian interferons on controlled pore glass (CPG) with modified surface.

    abstract::Spotted souslik's interferon beta (So IFN beta), bovine interferon beta (Bov IFN beta) and mouse IFN beta/a were purified on Controlled Pore Glass (CPG) using original CPG, not modified, and CPG with boron enriched surface. The surface boron atoms enrichment of CPG lead to higher selectivity of interferon binding and ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Kandefer-Szerszeń M,Kaczor J,Dawidowicz A

    更新日期:1986-01-01 00:00:00

  • Use of specific anti-HLA antibodies in clinical nephrology.

    abstract::In order to optimize the regimen of pathogenetic therapy of glomerulonephritis with nephrotic syndrome we used transfusions of plasma containing specific anti-HLA antibodies against the patient's phenotype as a part of the treatment in the acute stages of disease. The method was theoretically based on the conception o...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Buglova SE,Levin VI,Pilotovich VS,Kozlov GT,Drapezo LN

    更新日期:1995-01-01 00:00:00

  • Effect of serine proteinase inhibitors on intracellular free calcium rise in human polymorphonuclear leukocytes after stimulation with receptor agonists.

    abstract::The respiratory burst of polymorphonuclear leukocytes depends on activation of many enzymes and generation of variety of second messengers. One of important links leading to polymorphonuclear leukocytes (PMNL) activation is a transient rise in intracellular free calcium concentration ([Ca2+]i). Serine proteinase inhib...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Nowak D,Król M,Białasiewicz P

    更新日期:1998-01-01 00:00:00

  • Humoral immune system and ulcerative colitis activity. II. Complement level.

    abstract::C4, C3 and C5 levels and the complement hemolytic activity were analysed in 84 ulcerative colitis patients and correlated with activity, extension and duration of the disease, with the presence of extraintestinal manifestation, and with therapeutic effects. The elevation of C3 was observed in both mild active and in s...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Hermanowicz A,Sliwiński Z,Nawarska Z,Banaś B

    更新日期:1984-01-01 00:00:00

  • Identification of cells producing anti-treponemal lymphotoxin (ATL).

    abstract::Identification of cells producing ATL was carried out on suspensions of cells enriched with lymphocytes T, B and macrophages. The cells were isolated from the spleen of syphilitic rabbits and from their testes when the rabbits were infected intratesticularly. The isolation of lymphocytes and macrophages was performed ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Podwińska J

    更新日期:1987-01-01 00:00:00

  • Multi-functional roles of Stat3 revealed by conditional gene targeting.

    abstract::Signal transducer and activator of transcription (STAT) is a family of transcription factors composed of seven members. Gene-targeted mice of each STAT family protein displayed defective responses to cytokines, demonstrating an important role in cytokine-mediated biological responses. However, unlike the mice lacking ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:

    authors: Takeda K,Akira S

    更新日期:2001-01-01 00:00:00

  • Synergistic action of interferons (IFN-alpha/beta and IFN-gamma) of different species origin.

    abstract::The effects of the mixtures of human, porcine and murine interferons (IFNs) alpha, beta and gamma and bovine IFN-alpha were studied in human, porcine and murine cells. The synergistic action of the mixtures of IFN-alpha/beta and IFN-gamma occurred not only in the homologous but also in the heterologous systems. The sy...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Piasecki E

    更新日期:1987-01-01 00:00:00

  • The distribution of euchrysine-binding grains of the peripheral and bone marrow stem cells in different types of acute leukemia.

    abstract::The distribution of the fluorescent euchrysine-binding grains in the peripheral and bonmarrow stem cells was estimated in 28 cases of different types of acute leukemia verified according to Lòffler's cytochemical classification. The relationship between the pattern of fluorescent euchrysine-binding grains of human ste...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Mdzewski B,Tomaszewska Z,Romer B,Rokicka R,Krawczyński J,Kendziorek A,Derulska D

    更新日期:1984-01-01 00:00:00

  • The cytotoxic activity of heterologous anti-L-1210 antibodies conjugated with quinones.

    abstract::Biological effects of conjugates of quinone derivatives with antibodies were studied. Two methods of conjugation of aziridine derivatives of quinone with anti-L-1210 antibodies were used: the direct substitution of the protein amino groups or thiolation of immunoglobulins and subsequent substitution of the sulfhydryl ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Boratyński J,Syper L

    更新日期:1983-01-01 00:00:00

  • Autoreactive IgE in Chronic Spontaneous/Idiopathic Urticaria and Basophil/Mastocyte Priming Phenomenon, as a Feature of Autoimmune Nature of the Syndrome.

    abstract::Recent years of research have shed a new light on the role of IgE in immune reactions. It seems to be more than just a contribution to immediate type of allergic response. It appears that monomeric IgE may enhance mast cell activity without cross-linking of FcεRI by IgE specific allergen or autoreactive IgG anti-IgE a...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:10.1007/s00005-016-0417-7

    authors: Panaszek B,Pawłowicz R,Grzegrzółka J,Obojski A

    更新日期:2017-04-01 00:00:00

  • The immunological burden of human cytomegalovirus infection.

    abstract::Cytomegalovirus (CMV) is a persistent DNA virus that has evolved with humans to establish a finely balanced host-virus relationship. This balance is maintained by host immune surveillance since deficiencies in these processes can result in life-threatening disease, as observed in immunologically immature neonates and ...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:10.1007/s00005-007-0037-3

    authors: Khan N

    更新日期:2007-09-01 00:00:00

  • Phagocyte NADPH oxidase: a multicomponent enzyme essential for host defenses.

    abstract::Phagocytes such as neutrophils and monocytes play an essential role in host defenses against microbial pathogens. Reactive oxygen species (ROS), such as superoxide anion, hydrogen peroxide, the hydroxyl radical, and hypochlorous acid, together with microbicidal peptides and proteases, constitute their antimicrobial ar...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章,评审

    doi:

    authors: El-Benna J,Dang PM,Gougerot-Pocidalo MA,Elbim C

    更新日期:2005-05-01 00:00:00

  • New contact allergens and allergen sources.

    abstract::In the report new contact allergens and allergen sources detected in Warsaw in the period 1975-1977 are described. They are divided into 3 groups: industrial allergens, remaining occupational allergens and cosmetics. There are given some data concerning the substances present in industrial oils, hardeners and epoxy re...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Rudzki E,Grzywa Z,Krajewska D,Kozłowska A,Czerwińska-Dihm I

    更新日期:1978-01-01 00:00:00

  • Studies on nonspecific protection induced with OMP of Shigella flexneri and other genera of Enterobacteriaceae.

    abstract::Outer membrane proteins (OMP) isolated from Shigella flexneri, Escherichia coli, Proteus vulgaris and Salmonella typhimurium were tested for their protective activity. Each OMP preparate given to mice intraperitoneally in a single injection (5 micrograms/per mouse) protected the animals not only in homologous but also...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Czarny A,Witkowska D,Mulczyk M

    更新日期:1990-01-01 00:00:00

  • Influence of acute and chronic ethanol treatment on interferon production in mice.

    abstract::The effect of acute (single dose) and long-term ethanol treatment of Swiss Albino and C3H/He mice on IFN production stimulated in vitro by NDV, PHA and ConA was examined. Liver organ cultures and spleen cells of mice which received intraperitoneally a single dose (2 g/kg of body weight) of ethanol (II group) or were d...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Daniluk J,Kandefer-Szerszeń M

    更新日期:1994-01-01 00:00:00

  • Labeling of ribosomal ribonucleic acid with iodine 125I.

    abstract::RNA was labeled with iodine in the reaction catalyzed with lactoperoxidase (LP). Labeling of RNA requires additional purification of LP on Sephadex G-100 and application of RNase inhibitors. Immobilized LP shows lower activity than a soluble enzyme but still it is sufficient to label RNA to 7% IC. Immobilized enzyme i...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Gładek A,Mordarski M

    更新日期:1983-01-01 00:00:00

  • Induction of tumor necrosis factor and interleukin 6 by outer membrane proteins of Shigella in spleen cells and macrophages of mice.

    abstract::The ability of outer membrane proteins (OMP) of Shigella flexneri to induce tumor necrosis factor (TNF) and interleukin 6 (IL-6) production by spleen cells and macrophages of mice was investigated. Treatment of spleen cells with OMP resulted in the release of only traces of TNF activity. In contrast, macrophages treat...

    journal_title:Archivum immunologiae et therapiae experimentalis

    pub_type: 杂志文章

    doi:

    authors: Czarny A,Witkowska D,Mulczyk M

    更新日期:1993-01-01 00:00:00