Abstract:
:We present some practical extensions and applications of a strategy proposed by Thall, Simon and Estey for designing and monitoring single-arm clinical trials with multiple outcomes. We show by application how the strategy may be applied to construct designs for phase IIA activity trials and phase II equivalence trials. We also show how it may be extended to incorporate the use of mixture priors in settings where a Dirichlet distribution does not adequately quantify prior experience, randomized phase II selection trials involving two or more experimental treatments, and trials with group-sequential monitoring for applications involving multiple institutions.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Thall PF,Sung HGdoi
10.1002/(sici)1097-0258(19980730)17:14<1563::aid-ssubject
Has Abstractpub_date
1998-07-30 00:00:00pages
1563-80issue
14eissn
0277-6715issn
1097-0258pii
10.1002/(SICI)1097-0258(19980730)17:14<1563::AID-Sjournal_volume
17pub_type
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