Abstract:
:This article concerns construction of a confidence surface for tangential slopes of the dose-response surface of a combination therapy to identify where response increases as a function of drug dosage. This approach extends to the assessment of the effectiveness of the combination therapy.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Hung HMdoi
10.1002/sim.4780110513subject
Has Abstractpub_date
1992-03-01 00:00:00pages
703-11issue
5eissn
0277-6715issn
1097-0258journal_volume
11pub_type
杂志文章abstract::Multiple imputation by chained equations is a flexible and practical approach to handling missing data. We describe the principles of the method and show how to impute categorical and quantitative variables, including skewed variables. We give guidance on how to specify the imputation model and how many imputations ar...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4067
更新日期:2011-02-20 00:00:00
abstract::In a long-running longitudinal study using complex machinery to obtain measurements, it is sometimes necessary to replace the machine. This can result in lack of continuity in the measurements that can overwhelm any treatment effect or time trend. We propose a Bayesian procedure implemented using Markov chain Monte Ca...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1868
更新日期:2004-09-30 00:00:00
abstract::This paper, arising out of an event to honour the statistical and scientific contributions of Professor Peter Armitage, is concerned with research strategies and needs for chronic disease prevention. A few highlights from recent intervention trials for the prevention of cancer, cardiovascular disease, fractures and di...
journal_title:Statistics in medicine
pub_type:
doi:10.1002/sim.2045
更新日期:2004-11-30 00:00:00
abstract::For clinical trials with multiple treatment arms or endpoints a variety of sequentially rejective, weighted Bonferroni-type tests have been proposed, such as gatekeeping procedures, fixed sequence tests, and fallback procedures. They allow to map the difference in importance as well as the relationship between the var...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3495
更新日期:2009-02-15 00:00:00
abstract::In repeated measures settings, modeling the correlation pattern of the data can be immensely important for proper analyses. Accurate inference requires proper choice of the correlation model. Optimal efficiency of the estimation procedure demands a parsimonious parameterization of the correlation structure, with suffi...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3928
更新日期:2010-07-30 00:00:00
abstract::We examine the properties of several tests for goodness-of-fit for multinomial logistic regression. One test is based on a strategy of sorting the observations according to the complement of the estimated probability for the reference outcome category and then grouping the subjects into g equal-sized groups. A g x c c...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3202
更新日期:2008-09-20 00:00:00
abstract::Log-linear models for capture-recapture type data are widely used for estimating sizes of populations. Log-linear methods model conditional interactions between the sources. Often, however, the marginal associations are more appropriate and easier for the practitioner to conceptualize. Analyses here of previously publ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(19980115)17:1<69::aid-sim7
更新日期:1998-01-15 00:00:00
abstract::In this paper we study the problem of variable selection for the proportional odds model, which is a useful alternative to the proportional hazards model and might be appropriate when the proportional hazards assumption is not satisfied. We propose to fit the proportional odds model by maximizing the marginal likeliho...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2833
更新日期:2007-09-10 00:00:00
abstract::Assessment of equivalence or non-inferiority in accuracy between two diagnostic procedures often involves comparisons of paired areas under the receiver operating characteristic (ROC) curves. With some pre-specified clinically meaningful limits, the current approach to evaluating equivalence is to perform the two one-...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2358
更新日期:2006-04-15 00:00:00
abstract::Standard approaches to analysis of randomized controlled trials (RCTs) using Markov models make it difficult to generalize treatment effects to new patient groups and synthesize evidence across trials. This paper demonstrates how pair-wise and mixed treatment comparison meta-analysis can be applied to event history da...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4059
更新日期:2011-01-30 00:00:00
abstract::The present study investigates the performance of several statistical tests to detect publication bias in diagnostic meta-analysis by means of simulation. While bivariate models should be used to pool data from primary studies in diagnostic meta-analysis, univariate measures of diagnostic accuracy are preferable for t...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6177
更新日期:2014-08-15 00:00:00
abstract::A model is developed to estimate the effect of covariate imbalance on the size of a test of treatment efficacy in randomized clinical trials comparing two treatments when dispersion parameters are known. It is concluded that tests of homogeneity on the covariates should not be performed, that covariate imbalance is ju...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780080410
更新日期:1989-04-01 00:00:00
abstract::The introduction of potent antiretroviral therapies for treatment of HIV infection typically results in a dramatic reduction in plasma HIV RNA concentration, often to levels undetectable by current measurement practices. However, although a high proportion of patients achieve 'undetectability', many then experience a ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.1325
更新日期:2003-02-15 00:00:00
abstract::The design of a cross-sectional survey to estimate the age-specific incidence of an irreversible disease is considered, where the incidence rate is not changing over time and the risk of mortality is not affected by the onset of disease. The sample is assumed to give information on the current age and disease status o...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780132208
更新日期:1994-11-30 00:00:00
abstract::In the analysis of composite endpoints in a clinical trial, time to first event analysis techniques such as the logrank test and Cox proportional hazard test do not take into account the multiplicity, importance, and the severity of events in the composite endpoint. Several generalized pairwise comparison analysis met...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.8388
更新日期:2019-12-30 00:00:00
abstract::We study the group bridge and the adaptive group bridge penalties for competing risks quantile regression with group variables. While the group bridge consistently identifies nonzero group variables, the adaptive group bridge consistently selects variables not only at group level but also at within-group level. We all...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7619
更新日期:2018-04-30 00:00:00
abstract::We propose a two-step procedure to personalize drug dosage over time under the framework of a log-linear mixed-effect model. We model patients' heterogeneity using subject-specific random effects, which are treated as the realizations of an unspecified stochastic process. We extend the conditional quadratic inference ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7016
更新日期:2016-10-30 00:00:00
abstract::In an individually matched case-control study, effects of potential risk factors are ascertained through conditional logistic regression (CLR). Extension of CLR to situations with multiple disease or reference categories has been made through polychotomous CLR and is shown to be more efficient than carrying out separa...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2790
更新日期:2007-07-30 00:00:00
abstract::We develop reinforcement learning trials for discovering individualized treatment regimens for life-threatening diseases such as cancer. A temporal-difference learning method called Q-learning is utilized that involves learning an optimal policy from a single training set of finite longitudinal patient trajectories. A...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3720
更新日期:2009-11-20 00:00:00
abstract::Many neuroscientists are interested in how connectomes (graphical representations of functional connectivity between areas of the brain) change in relation to covariates. In statistics, changes like this are analyzed using regression, where the outcomes or dependent variables are regressed onto the covariates. However...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.8374
更新日期:2019-12-20 00:00:00
abstract::Spatial scan statistics are widely used for count data to detect geographical disease clusters of high or low incidence, mortality or prevalence and to evaluate their statistical significance. Some data are ordinal or continuous in nature, however, so that it is necessary to dichotomize the data to use a traditional s...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2607
更新日期:2007-03-30 00:00:00
abstract::When designing a study to develop a new prediction model with binary or time-to-event outcomes, researchers should ensure their sample size is adequate in terms of the number of participants (n) and outcome events (E) relative to the number of predictor parameters (p) considered for inclusion. We propose that the mini...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7992
更新日期:2019-03-30 00:00:00
abstract::In modern observational studies using electronic health records or other routinely collected data, both the outcome and covariates of interest can be error-prone and their errors often correlated. A cost-effective solution is the two-phase design, under which the error-prone outcome and covariates are observed for all...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.8799
更新日期:2021-02-10 00:00:00
abstract::In the recent two decades, data mining methods for signal detection have been developed for drug safety surveillance, using large post-market safety data. Several of these methods assume that the number of reports for each drug-adverse event combination is a Poisson random variable with mean proportional to the unknow...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6510
更新日期:2015-08-30 00:00:00
abstract::We consider the problem of comparing cumulative incidence functions of non-mortality events in the presence of informative coarsening and the competing risk of death. We extend frequentist-based hypothesis tests previously developed for non-informative coarsening and propose a novel Bayesian method based on comparing ...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3397
更新日期:2008-12-10 00:00:00
abstract::There are many settings in which the distribution of error in a mismeasured covariate varies with the value of another covariate. Take, for example, the case of HIV phylogenetic cluster size, large values of which are an indication of rapid HIV transmission. Researchers wish to find behavioral correlates of HIV phylog...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7289
更新日期:2017-07-30 00:00:00
abstract::The estimation of attributable risk in the presence of confounding and effect modification is studied in this paper. Different adjustment methods for the attributable risk are reviewed. The results of a stimulation study comparing these methods under the unrestricted multinomial sampling model are reported. From the s...
journal_title:Statistics in medicine
pub_type: 杂志文章,评审
doi:10.1002/sim.4780111606
更新日期:1992-12-01 00:00:00
abstract::Estimates of transmission probabilities for sexually transmitted diseases historically come from studies of uninfected individuals exposed to those with a high disease prevalence (for example, prostitutes). However, changes in sexual behaviour, much of which relates to concerns about AIDS, has made identification of p...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780110502
更新日期:1992-03-01 00:00:00
abstract::Generalized linear models are often assumed to fit propensity scores, which are used to compute inverse probability weighted (IPW) estimators. To derive the asymptotic properties of IPW estimators, the propensity score is supposed to be bounded away from zero. This condition is known in the literature as strict positi...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.7827
更新日期:2018-10-30 00:00:00
abstract::Writing the variance of the Mantel-Haenszel estimator under the null of homogeneity and inverting the corresponding test, we arrive at an improved confidence interval for the common risk difference in stratified 2 × 2 tables. This interval outperforms a variety of other intervals currently recommended in the literatur...
journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.6122
更新日期:2014-07-30 00:00:00