A measure of similarity for response curves based on ranks.

abstract：:Estimates of relative efficacy between alternative treatments are crucial for decision making in health care. Bayesian mixed treatment comparison models provide a powerful methodology to obtain such estimates when head-to-head evidence is not available or insufficient. In recent years, this methodology has become wide...

journal_title：Statistics in medicine

authors： Schmitz S,Adams R,Walsh C

更新日期：2013-07-30 00:00:00

abstract：:To study the effect of a mega hydropower dam in southwest Ethiopia on malaria incidence, we have set up a longitudinal study. To gain insight in temporal and spatial aspects, that is, in time (period  =  year-season combination) and location (village), we need models that account for these effects. The frailty model w...

journal_title：Statistics in medicine

authors： Getachew Y,Janssen P,Yewhalaw D,Speybroeck N,Duchateau L

更新日期：2013-08-15 00:00:00

abstract：:Within the rich literature on generalized linear models, substantial efforts have been devoted to models for categorical responses that are either completely ordered or completely unordered. Few studies have focused on the analysis of partially ordered outcomes, which arise in practically every area of study, includin...

journal_title：Statistics in medicine

authors： Zhang Q,Ip EH

更新日期：2012-01-13 00:00:00

abstract：:When data are dichotomous, this paper notes the utility of inverse sampling in establishing equivalence with respect to the risk ratio. This paper develops an exact equivalence test that accounts for the risk ratio under inverse sampling and further discusses the relationship between the exact equivalence test and the...

journal_title：Statistics in medicine

authors： Lui KJ

更新日期：1997-08-15 00:00:00

abstract：:The power prior has been widely used in many applications covering a large number of disciplines. The power prior is intended to be an informative prior constructed from historical data. It has been used in clinical trials, genetics, health care, psychology, environmental health, engineering, economics, and business. ...

journal_title：Statistics in medicine

authors： Ibrahim JG,Chen MH,Gwon Y,Chen F

更新日期：2015-12-10 00:00:00

abstract：:We examine Goodman and Kruskal's lambda using Efron's approach to regression and analysis of variance (ANOVA) for zero-one outcome data. For a binary response cross-classified by a single nominal predictor, we present a computationally simple ANOVA table in which lambda is analogous to Pearson's R-square. We character...

journal_title：Statistics in medicine

authors： Makuch RW,Rosenberg PS,Scott G

更新日期：1989-05-01 00:00:00

abstract：:Modelling disease clustering over space and time can be helpful in providing indications of possible exposures and planning corresponding public health practices. Though a considerable number of studies focus on modelling spatio-temporal patterns of disease, most of them do not directly model a spatio-temporal cluster...

journal_title：Statistics in medicine

authors： Yan P,Clayton MK

更新日期：2006-03-15 00:00:00

abstract：:In phase 3 clinical trials, ethical and financial concerns motivate sequential analyses in which the data are analyzed prior to completion of the entire planned study. Existing group sequential software accounts for the effects of these interim analyses on the sampling density by assuming that the contribution of subs...

journal_title：Statistics in medicine

authors： Shoben AB,Emerson SS

更新日期：2014-12-20 00:00:00

abstract：:A number of variance formulae for the attributable fraction have been presented, but none is consistent in sparse data, such as found in individually matched case-control studies. This paper employs Mantel-Haenszel estimation to derive variance estimators for attributable fractions that are dually consistent, that is,...

journal_title：Statistics in medicine

authors： Greenland S

更新日期：1987-09-01 00:00:00

abstract：:This paper discusses the various philosophies that influence the selection of patients for entry into randomized controlled trials. Although a number of different and often competing issues have to be considered depending upon the trial, keeping entry criteria simple, wide and at times even flexible is usually prefera...

journal_title：Statistics in medicine

authors： Yusuf S,Held P,Teo KK,Toretsky ER

更新日期：1990-01-01 00:00:00

abstract：:Hierarchical regression analysis holds much promise for epidemiologic analysis, but has as yet seen limited application because of lack of easily used software and the relatively lengthy run times of preferred fitting methods (such as true maximum likelihood and Bayesian approaches). This paper compares three relative...

journal_title：Statistics in medicine

authors： Greenland S

更新日期：1997-03-15 00:00:00

abstract：:Assessing the QT prolongation potential of a drug is typically done based on pivotal safety studies called thorough QT studies. Model-based estimation of the drug-induced QT prolongation at the estimated mean maximum drug concentration could increase efficiency over the currently used intersection-union test. However,...

journal_title：Statistics in medicine

authors： Dosne AG,Bergstrand M,Karlsson MO,Renard D,Heimann G

更新日期：2017-10-30 00:00:00

abstract：:Cox proportional hazard regression model is a popular tool to analyze the relationship between a censored lifetime variable with other relevant factors. The semiparametric Cox model is widely used to study different types of data arising from applied disciplines such as medical science, biology, and reliability studie...

journal_title：Statistics in medicine

authors： Ghosh A,Basu A

更新日期：2019-11-30 00:00:00

abstract：:Delay in the outcome variable is challenging for outcome-adaptive randomization, as it creates a lag between the number of subjects accrued and the information known at the time of the analysis. Motivated by a real-life pediatric ulcerative colitis trial, we consider a case where a short-term predictor is available fo...

journal_title：Statistics in medicine

authors： Kim MO,Liu C,Hu F,Lee JJ

更新日期：2014-10-15 00:00:00

abstract：:Methods for dealing with tied event times in the Cox proportional hazards model are well developed. Also, the partial likelihood provides a natural way to handle covariates that change over time. However, ties between event times and the times that discrete time-varying covariates change have not been systematically s...

journal_title：Statistics in medicine

authors： Xin X,Horrocks J,Darlington GA

更新日期：2013-06-30 00:00:00

abstract：:Cancer immunotherapy trials have two special features: a delayed treatment effect and a cure rate. Both features violate the proportional hazard model assumption and ignoring either one of the two features in an immunotherapy trial design will result in substantial loss of statistical power. To properly design immunot...

journal_title：Statistics in medicine

authors： Wei J,Wu J

更新日期：2020-03-15 00:00:00

abstract：:Most statistical methodology for phase III clinical trials focuses on the comparison of a single experimental treatment with a control. An increasing desire to reduce the time before regulatory approval of a new drug is sought has led to development of two-stage or sequential designs for trials that combine the defini...

journal_title：Statistics in medicine

authors： Stallard N,Todd S

更新日期：2003-03-15 00:00:00

abstract：:Researchers in clinical science and bioinformatics frequently aim to learn which of a set of candidate biomarkers is important in determining a given outcome, and to rank the contributions of the candidates accordingly. This article introduces a new approach to research questions of this type, based on targeted maximu...

journal_title：Statistics in medicine

authors： Bembom O,Petersen ML,Rhee SY,Fessel WJ,Sinisi SE,Shafer RW,van der Laan MJ

更新日期：2009-01-15 00:00:00

abstract：:The case-control study is a simple and an useful method to characterize the effect of a gene, the effect of an exposure, as well as the interaction between the two. The control-free case-only study is yet an even simpler design, if interest is centered on gene-environment interaction only. It requires the sometimes pl...

journal_title：Statistics in medicine

authors： Lee WC,Wang LY,Cheng KF

更新日期：2010-10-30 00:00:00

abstract：:Generalized linear models are often assumed to fit propensity scores, which are used to compute inverse probability weighted (IPW) estimators. To derive the asymptotic properties of IPW estimators, the propensity score is supposed to be bounded away from zero. This condition is known in the literature as strict positi...

journal_title：Statistics in medicine

authors： Molina J,Sued M,Valdora M

更新日期：2018-10-30 00:00:00

abstract：:The purpose of this research was to develop appropriate methods for analysing repeated ordinal categorical data that arose in an intervention trial to prevent oesophageal cancer. The measured response was the degree of oesophageal dysplasia at 2.5 and 6 years after randomization. An important feature was that some res...

journal_title：Statistics in medicine

authors： Mark SD,Gail MH

更新日期：1994-03-15 00:00:00

abstract：:The asymptotic Pearson's chi-squared test and Fisher's exact test have long been the most used for testing association in 2x2 tables. Unconditional tests preserve the significance level and generally are more powerful than Fisher's exact test for moderate to small samples, but previously were disadvantaged by being co...

journal_title：Statistics in medicine

authors： Lydersen S,Fagerland MW,Laake P

更新日期：2009-03-30 00:00:00

abstract：:This paper discusses methods of identifying the types of missingness in quality of life (QOL) data in cancer clinical trials. The first approach involves collecting information on why the QOL questionnaires were not completed. Based on the reasons provided one may be able to distinguish the mechanisms causing missing ...

journal_title：Statistics in medicine

authors： Curran D,Bacchi M,Schmitz SF,Molenberghs G,Sylvester RJ

更新日期：1998-03-15 00:00:00

abstract：:We propose a probability distribution for an equivalence class of classification trees (that is, those that ignore the value of the cutpoints but retain tree structure). This distribution is parameterized by a central tree structure representing the true model, and a precision or concentration coefficient representing...

journal_title：Statistics in medicine

authors： Shannon WD,Banks D

更新日期：1999-03-30 00:00:00

abstract：:In the pharmaceutical industry, an assay method is considered validated if the accuracy and precision for an assay meet some acceptable limits. This paper discusses the assessment of assay precision in terms of the estimation of total variability of an assay from a one-way random effects model which is often considere...

journal_title：Statistics in medicine

authors： Chow SC,Tse SK

更新日期：1991-10-01 00:00:00

abstract：:The statistical analysis of panel count data has recently attracted a great deal of attention, and a number of approaches have been developed. However, most of these approaches are for situations where the observation and follow-up processes are independent of the underlying recurrent event process unconditional or co...

journal_title：Statistics in medicine

authors： Li N,Zhao H,Sun J

更新日期：2013-07-30 00:00:00

abstract：:In the pharmaceutical industry, some tests for quality assurance before, during and after the manufacture of a drug product involve a two-stage sampling technique. We propose statistical testing procedures in a two-stage sampling problem with large within-class sample sizes. We also derive a two-stage sampling plan by...

journal_title：Statistics in medicine

authors： Shao J,Chow SC

更新日期：1993-11-15 00:00:00

abstract：:The goal of screening programmes for cancer is early detection and treatment with a consequent reduction in mortality from the disease. Screening programmes need to assess the true benefit of screening, that is, the length of time of extension of survival beyond the time of advancement of diagnosis (lead-time). This p...

journal_title：Statistics in medicine

authors： Xu JL,Prorok PC

更新日期：1995-12-30 00:00:00

abstract：:Predicting an individual's risk of experiencing a future clinical outcome is a statistical task with important consequences for both practicing clinicians and public health experts. Modern observational databases such as electronic health records provide an alternative to the longitudinal cohort studies traditionally ...

journal_title：Statistics in medicine

authors： Wolfson J,Bandyopadhyay S,Elidrisi M,Vazquez-Benitez G,Vock DM,Musgrove D,Adomavicius G,Johnson PE,O'Connor PJ

更新日期：2015-09-20 00:00:00

abstract：:The 'landmark' and 'Simon and Makuch' non-parametric estimators of the survival function are commonly used to contrast the survival experience of time-dependent treatment groups in applications such as stem cell transplant versus chemotherapy in leukemia. However, the theoretical survival functions corresponding to th...

journal_title：Statistics in medicine

authors： Bernasconi DP,Rebora P,Iacobelli S,Valsecchi MG,Antolini L

更新日期：2016-03-30 00:00:00