Selection of patients for randomized controlled trials: implications of wide or narrow eligibility criteria.

Abstract:

:This paper discusses the various philosophies that influence the selection of patients for entry into randomized controlled trials. Although a number of different and often competing issues have to be considered depending upon the trial, keeping entry criteria simple, wide and at times even flexible is usually preferable. Such a strategy can be a positive virtue by helping to attain the large numbers of patients that are usually needed to reliably detect the sorts of moderate benefits that are plausible, at a reasonable cost and by providing answers that are relevant to many different categories of patients with a particular condition.

journal_name

Stat Med

journal_title

Statistics in medicine

authors

Yusuf S,Held P,Teo KK,Toretsky ER

doi

10.1002/sim.4780090114

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

73-83; discussion 83-6

issue

1-2

eissn

0277-6715

issn

1097-0258

journal_volume

9

pub_type

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