Abstract:
:The purpose of this study was to investigate the effects of recombinant human erythropoietin (rHuEPO) administration on energy metabolism during exercise. Specifically, the contribution of anaerobic (glycogen) metabolism during exercise was evaluated. Sprague-Dawley rats were randomly assigned to an experimental [rHuEPO] (600 U x kg(-1) of Eprex, every 3 days) or control (equivalent volume of saline) group. After 15 days of treatment, animals from both groups were randomly subjected to either a 30-minute exercise (swimming with 5% body weight added) or resting period. They were sacrificed at the end of the exercise period. Their liver and muscles were quickly removed and frozen in liquid nitrogen. Blood was also sampled. rHuEPO administration resulted in a significant (P < 0.05) increase of hematocrit (from 42 +/- 2 to 54 +/- 7 L/L). In the rHuEPO group, both muscle glycogen and free fatty acids were higher whereas lactate was lower at the conclusion of the exercise period (P < 0.05). These results suggest that energy substrate utilization during exercise is affected by enhanced oxygen availability. Finally, a lower overall contribution to energy production from anaerobic metabolism during exercise followed rHuEPO administration.
journal_name
Int J Sports Medjournal_title
International journal of sports medicineauthors
Lavoie C,Diguet A,Milot M,Gareau Rdoi
10.1055/s-2007-971919subject
Has Abstractpub_date
1998-05-01 00:00:00pages
281-6issue
4eissn
0172-4622issn
1439-3964journal_volume
19pub_type
杂志文章abstract::One hundred and three women who were habitual distance runners and 74 age-matched physically inactive women provided three-day diet records. Intergroup differences in intakes of energy nutrients, micronutrients, cholesterol and fiber were evaluated via analysis of variance and, to assess qualitative differences, via a...
journal_title:International journal of sports medicine
pub_type: 杂志文章
doi:10.1055/s-2007-1024838
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journal_title:International journal of sports medicine
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journal_title:International journal of sports medicine
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更新日期:1988-08-01 00:00:00
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更新日期:2001-05-01 00:00:00
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更新日期:2010-09-01 00:00:00
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journal_title:International journal of sports medicine
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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更新日期:2018-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1055/s-2008-1025925
更新日期:1984-12-01 00:00:00
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journal_title:International journal of sports medicine
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更新日期:1991-06-01 00:00:00
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journal_title:International journal of sports medicine
pub_type: 杂志文章
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journal_title:International journal of sports medicine
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更新日期:1994-04-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:International journal of sports medicine
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journal_title:International journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2007-971969
更新日期:1998-06-01 00:00:00
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journal_title:International journal of sports medicine
pub_type: 杂志文章
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