Treatment of ulcerative colitis with germinated barley foodstuff feeding: a pilot study.

Abstract:

BACKGROUND:Germinated barley foodstuff (GBF) has been shown to attenuate intestinal injury in animal models, largely by increasing luminal short-chain fatty acid production. AIM:To investigate the safety and efficacy of GBF in the treatment of ulcerative colitis (UC). METHODS:Ten patients with active UC received 30 g of GBF daily for 4 weeks in an open-label treatment protocol while the baseline anti-inflammatory therapy was continued. The response to treatment was evaluated clinically and endoscopically. Pre- and post-treatment stool concentrations of short-chain fatty acids were measured by gas-liquid chromatography. RESULTS:Patients showed improvement in their clinical activity index scores, with a significant decrease in the score from 6.9+/-1.4 to 2.8+/-1.5 (mean+/-S.E.M., P < 0.05). The endoscopic index score fell from 6.1+/-2.3 to 3.8+/-2.3 (P < 0.0001). Patients showed an increase in stool butyrate concentrations after GBF treatment (P < 0.05). No side-effects were observed. CONCLUSIONS:Oral GBF therapy may have a place in management of ulcerative colitis, but controlled studies are needed to demonstrate its efficacy in the treatment of this disorder.

journal_name

Aliment Pharmacol Ther

authors

Mitsuyama K,Saiki T,Kanauchi O,Iwanaga T,Tomiyasu N,Nishiyama T,Tateishi H,Shirachi A,Ide M,Suzuki A,Noguchi K,Ikeda H,Toyonaga A,Sata M

doi

10.1046/j.1365-2036.1998.00432.x

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

1225-30

issue

12

eissn

0269-2813

issn

1365-2036

journal_volume

12

pub_type

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  • Clarithromycin-amoxycillin therapy for Helicobacter pylori infection.

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    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2036.1994.tb00313.x

    authors: al-Assi MT,Genta RM,Karttunen TJ,Graham DY

    更新日期:1994-08-01 00:00:00

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    abstract::The study investigated the oral absorption of two antifungal agents, fluconazole and itraconazole, under conditions of low intragastric acidity. Twelve healthy male volunteers received each of 4 dosing regimens: 200 mg itraconazole alone, 200 mg itraconazole and famotidine, 100 mg fluconazole alone, and 100 mg flucona...

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    pub_type: 杂志文章

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    更新日期:1993-06-01 00:00:00