Abstract：
:The effects of identical morning (08.05 hours) and evening (20.05 hours) meals on intragastric pH were compared in 12 healthy volunteers receiving gastric antisecretory medication. Dosing included continuous intravenous infusion ranitidine (50 mg bolus followed by 12.5 mg/h) or a matching placebo which were randomly administered prior to and following 7 days of treatment with oral omeprazole (40 mg mane). Intragastric pH was monitored continuously using a tethered indwelling pH probe. Subjects were divided into groups, one of which began the pH monitoring session in the morning, the other in the evening. The median 24-h intragastric pH was significantly increased by all active dosing regimens (P less than 0.05). Combined omeprazole and ranitidine produced the highest median pH, 5.92. However, a breakthrough drop in intragastric pH occurred during the evening after all active dosing. Intragastric pH fell prior to and after consumption of the evening meal with median pH values less than 4 during all sessions. The evening meal led to significantly lower intragastric pH compared to the morning meal for omeprazole and the combined omeprazole and ranitidine dosing periods (P less than 0.05). There was no difference between morning and evening pH during the placebo or ranitidine periods. Ranitidine and omeprazole, either alone or in combination, were unable to prevent the meal-stimulated decline in intragastric pH during the evening time period.
journal_name
Aliment Pharmacol Therjournal_title
Alimentary pharmacology & therapeuticsauthors
Sanders SW,Moore JG,Day GM,Tolman KGdoi
10.1111/j.1365-2036.1992.tb00262.xsubject
Has Abstractpub_date
1992-04-01 00:00:00pages
187-93issue
2eissn
0269-2813issn
1365-2036journal_volume
6pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND:Delayed gastric emptying, impaired gastric accommodation to a meal and hypersensitivity to gastric distension have been implied in the pathophysiology of functional dyspepsia. Dyspeptic patients are often treated with the prokinetic drug cisapride. AIM:To assess the effects of cisapride on perception of gas...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2036.1998.00366.x
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND:Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the intestine, which frequently require surgery for complications or failure of medical therapy. AIM:To seek evidence and provide direction for clinicians on optimal strategies to enable steroid free remission in inflammat...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.2008.03753.x
更新日期：2008-09-15 00:00:00
abstract：BACKGROUND:Functional dyspepsia is a heterogeneous condition and a uniform response to drug treatment is not likely. This may be the reason for the general failure of acid suppression in clinical trials in these patients. It may be more rewarding to identify true responders to drug treatment by a single subject trial. ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2036.2000.00866.x
更新日期：2000-11-01 00:00:00
abstract：:This review summarizes the clinical evidence to support current therapies in irritable bowel syndrome (IBS). Fibre is indicated at a dose of at least 12 g per day in patients with constipation-predominant IBS. Loperamide (and probably other opioid agonists) are of proven benefit in diarrhoea-predominant IBS; loperamid...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：
更新日期：1999-05-01 00:00:00
abstract：:Deficiency of any of the vitamins and minerals essential for normal erythropoiesis (haematinics), including iron, copper, cobalt, vitamins A, B12, B6, C, E, folic acid, riboflavin and nicotinic acid, may be associated with defective erythropoiesis and anaemia. Iron, vitamin B12 and folate are the haematinics for which...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2036.1998.00368.x
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND:Endothelins have been implicated in gastric mucosal damage in a variety of animal models. Exogenous ET-1 and ET-3 are causally associated with experimental gastric ulcers. Furthermore, clinical reports also show elevated plasma and gastric mucosal endothelin-1 levels in patients suffering from peptic ulcers....
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2036.1999.00503.x
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is expected to become a leading aetiology of hepatocellular carcinoma (HCC)-related mortality in the United States. HCC treatments with curative intent (OLT, orthotopic liver transplantation; resection; RFA, radiofrequency ablation) can improve survival in carefully ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.14342
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:The effect of direct-acting anti-virals (DAAs) in children and adolescents with chronic hepatitis C virus (HCV) infection is difficult to determine, since few, aged between 3 and 18 years, have been enrolled in clinical trials, and some data come from observational studies. AIM:To summarise the evidence on ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,meta分析
doi：10.1111/apt.16037
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Obscure gastrointestinal bleeding (OGIB) is a commonly encountered clinical problem in gastroenterology and is associated with significant morbidity and mortality. The investigation and management of OGIB has changed dramatically over the past decade with the advent of newer gastroenterological and radiologi...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.2011.04744.x
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Proton pump inhibitors including omeprazole and lansoprazole inhibit gastric acid secretion by selectively and non-competitively inactivating the H+, K+ ATPase molecules of the parietal cell, but possibly only those that are actively secreting acid. This might imply that stimulation of acid secretion by a me...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2036.2000.00829.x
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND:The most commonly used second-line Helicobacter pylori eradication regimens are bismuth-containing quadruple therapy and levofloxacin-containing triple therapy, both offering suboptimal results. Combining bismuth and levofloxacin may enhance the efficacy of rescue eradication regimens. AIMS:To evaluate the ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1111/apt.13128
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Activation of human and non-human colonic beta(beta)3-adrenoceptors causes smooth muscle relaxation. beta3-Adrenoceptor agonists protect against experimental indomethacin-induced jejunal ulceration. The mechanism of protection may involve spasmolytic/vasodilatory agonist activity. The precise localization of...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2036.1998.00345.x
更新日期：1998-06-01 00:00:00
abstract：:The effect of 7 days of oral dosing with 5 mg day-1 and 20 mg day-1 omeprazole on basal and pentagastrin-stimulated gastric acid output was studied in nine duodenal ulcer patients. Basal acid output measured 5-6 h post-dosing was decreased by a mean of 75% on 5 mg omeprazole and by 90% on 20 mg omeprazole (P less than...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2036.1988.tb00696.x
更新日期：1988-06-01 00:00:00
abstract：BACKGROUND:Pantoprazole is a new substituted benzimidazole that blocks the H+/K(+)-ATPase in the gastric mucosa and thus inhibits acid secretion. METHODS:Efficacy and tolerability of pantoprazole (40 mg at breakfast) and ranitidine (300 mg at bedtime) in the treatment of uncomplicated acute duodenal ulcer were compare...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1365-2036.1994.tb00163.x
更新日期：1994-02-01 00:00:00
abstract：BACKGROUND:Re-bleeding of Helicobacter pylori-associated peptic ulcer disease is reduced by H. pylori eradication. AIM:To validate a non-invasive test, the Premium Platinum HpSA stool test, in patients with upper gastrointestinal bleeding. METHODS:Stool samples of consecutive patients with relevant bleeding from gast...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2036.2003.01548.x
更新日期：2003-04-01 00:00:00
abstract：AIM:To perform a systematic review on the efficacy of intermittent and on-demand therapy with either histamine H2-receptor antagonists or proton pump inhibitors for patients with erosive oesophagitis or symptomatic heartburn. METHOD:We conducted randomized-controlled trials of non-continuous therapy in gastro-oesophag...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.2005.02490.x
更新日期：2005-06-01 00:00:00
abstract：:Physicians occasionally embark on a work-up that, after a lengthy path, leads them to a clinical situation similar to that from which they started their original pursuit. This article aims to describe the characteristics of circular medical management and means for its avoidance. The underlying medical problem often p...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.0269-2813.2004.01849.x
更新日期：2004-01-15 00:00:00
abstract：BACKGROUND:The therapeutic efficacy of 5-aminosalicylic acid in inflammatory bowel disease may be related to its antioxidant properties. AIM:To compare in vitro the antioxidant effects of conventional drugs (5-aminosalicylic acid, corticosteroids, metronidazole), with new aminosalicylates (4-aminosalicylic acid, balsa...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2036.1999.00484.x
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND:In patients with chronic hepatitis C virus infection and persistently normal alanine aminotransferase levels, liver fibrosis has been reported in 0-22% of cases and advanced liver disease in 5-10% of cases. AIM:To determine whether patients with persistently normal alanine aminotransferase levels clear infe...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1111/j.1365-2036.2004.01844.x
更新日期：2004-02-01 00:00:00
abstract：BACKGROUND:Combination treatment with azathioprine for 6-12 months is the preferred strategy for starting infliximab due to improved pharmacokinetics. However, optimised infliximab monotherapy with proactive dose escalations in case of low trough levels is a safer but under-studied alternative. AIM:To compare the clin...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.15179
更新日期：2019-04-01 00:00:00
abstract：:Candidiasis of the oropharynx and oesophagus is one of the most common problems encountered in patients with HIV disease. Fluconazole is a bis-triazole antifungal agent with a long serum half-life. Sixteen anti-HIV positive patients (15 haemophiliacs and one blood transfusion recipient) with a clinical diagnosis of or...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2036.1991.tb00021.x
更新日期：1991-04-01 00:00:00
abstract：:An elevated platelet count is well recognized as a marker of inflammatory bowel disease activity. There is an increased incidence of systemic thromboembolism in this disease. Recent work indicates that platelets exhibit several proinflammatory properties including release of inflammatory mediators, and recruitment, ch...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2036.1997.153328000.x
更新日期：1997-04-01 00:00:00
abstract：AIM:To estimate the cost-effectiveness over a 4-year duration of lamivudine and adefovir dipivoxil for patients with hepatitis B 'e' antigen-negative chronic hepatitis B. METHODS:A decision analysis model has been used to perform a cost-effectiveness analysis of lamivudine and adefovir dipivoxil from the perspective o...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2006.02767.x
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:Hepatitis B (HBV)-infected patients have a higher morbidity and mortality when super-infected by hepatitis A (HAV). AIM:To evaluate the immunogenicity and safety of a commercial inactivated HAV vaccine in Chinese patients with chronic HBV infection. METHODS:Sixty-five HBV-infected patients (30 carriers, 22...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-2036.1999.00628.x
更新日期：1999-11-01 00:00:00
abstract：BACKGROUND:In the past decade, a number of population-based studies have examined the prevalence of coeliac disease in individuals with type 1 diabetes but prevalences have differed considerably. AIM:To examine the prevalence of coeliac disease in individuals with type 1 diabetes. METHODS:A systematic review of Engli...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,meta分析,评审
doi：10.1111/apt.12973
更新日期：2014-11-01 00:00:00
abstract：:The effects of treatment with the Chinese herbal medicine Liu-Jun-Zi-Tang (TJ-43) on gastric emptying and gastrointestinal symptoms were investigated in 42 patients with chronic idiopathic dyspepsia. By random allocation, 22 patients received oral treatment with 2.5 g TJ-43 three times daily, and 20 patients received ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2036.1993.tb00120.x
更新日期：1993-08-01 00:00:00
abstract：BACKGROUND:Hepatocellular carcinoma is the leading cause of death in cirrhosis. A majority of patients present at an advanced stage with poor prognosis. AIM:To review the current screening, diagnosis and management strategies involved in hepatocellular carcinoma. METHODS:A literature search was performed using PubMed...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.2009.04200.x
更新日期：2010-02-15 00:00:00
abstract：BACKGROUND:Non-cardiac chest pain is one of the most common functional gastrointestinal disorders. By recognising that gastro-oesophageal reflux disease (GERD), oesophageal dysmotility and oesophageal hypersensitivity are the main underlying mechanisms of NCCP, a more directed therapeutic approach has been developed. ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/apt.13458
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Ulcerative colitis with diverticulosis (UCD), segmental colitis associated with diverticulosis (SCAD) and acute uncomplicated diverticulitis (AUD) may affect the same colonic regions, but the real incidence of these entities in clinical practice is unknown. AIM:To assess the incidence and the endoscopic fin...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2010.04530.x
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:Ingestion of capsaicin reduces symptoms in functional dyspepsia but induces upper abdominal symptoms initially. AIMS:To evaluate the effects of one week of oral dosing with capsaicin on mechanonociception and chemonociception. METHODS:Healthy subjects ingested capsules containing 0.5 mg capsaicin t.d.s (n ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2006.03022.x
更新日期：2006-08-15 00:00:00
