Abstract:
:The method based on the Kolmogorov backward equations of Little (1995, Biometrics 51, 1278-1291) for computing hazard functions for the multistage carcinogenesis models fails when model parameters are time-dependent. In addition to suggesting an alternative method based on the Kolmogorov forward equation, this note highlights the interplay of the forward equation, the backward equation, and the characteristic method. Advantages and disadvantages of the forward and backward equations are discussed.
journal_name
Biometricsjournal_title
Biometricsauthors
Zheng Qsubject
Has Abstractpub_date
1998-03-01 00:00:00pages
384-8issue
1eissn
0006-341Xissn
1541-0420journal_volume
54pub_type
杂志文章相关文献
BIOMETRICS文献大全abstract::Spatial cluster detection is an important methodology for identifying regions with excessive numbers of adverse health events without making strong model assumptions on the underlying spatial dependence structure. Previous work has focused on point or individual-level outcome data and few advances have been made when ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2009.01323.x
更新日期:2010-09-01 00:00:00
abstract::A multiple toxicity model for the quantal response of organisms is constructed based on an existing bivariate theory. The main assumption is that the tolerances follow a multivariate normal distribution function. However, any monotone tolerance distribution can be applied by mapping the integration region in the n-dim...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1985-09-01 00:00:00
abstract::The matrix considered contains four elements, each a function of total number. A special case for which the matrix may be appropriate is when the population may be divided into juveniles and adults, and the survival rates and fecundity are the same for all members of each group. This is true, at least approximatley, f...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1976-06-01 00:00:00
abstract::Bayesian experimental design for a clinical trial involves specifying a utility function that models the purpose of the trial, in this case the selection of patients for a diagnostic test. The best sample of patients is selected by maximizing expected utility. This optimization task poses difficulties due to a high-di...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2008.01156.x
更新日期:2009-09-01 00:00:00
abstract::A critical component of longitudinal study design involves determining the sampling schedule. Criteria for optimal design often focus on accurate estimation of the mean profile, although capturing the between-subject variance of the longitudinal process is also important since variance patterns may be associated with ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12714
更新日期:2018-03-01 00:00:00
abstract::The paper here presented was motivated by a case study involving high-dimensional and high-frequency tidal volume traces measured during induced panic attacks. The focus was to develop a procedure to determine the significance of whether a mean curve dominates another one. The key idea of the suggested method relies o...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2007.00959.x
更新日期:2008-09-01 00:00:00
abstract::This paper considers the problem of extending the classical moving average models to time series with conditional distributions given by generalized linear models. These models have the advantage of easy construction and estimation. Statistical modelling techniques are also proposed. Some simulation results and an ill...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::Calibration, the statistical consistency of forecast distributions and the observations, is a central requirement for probabilistic predictions. Calibration of continuous forecasts is typically assessed using the probability integral transform histogram. In this article, we propose significance tests based on scoring ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2010.01406.x
更新日期:2010-12-01 00:00:00
abstract:SUMMARY:Many hormones are secreted in pulses. The pulsatile relationship between hormones regulates many biological processes. To understand endocrine system regulation, time series of hormone concentrations are collected. The goal is to characterize pulsatile patterns and associations between hormones. Currently each ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2008.01117.x
更新日期:2009-06-01 00:00:00
abstract::The variogram is a standard tool in the analysis of spatial data, and its shape provides useful information on the form of spatial correlation that may be present. However, it is also useful to be able to assess the evidence for the presence of any spatial correlation. A method of doing this, based on an assessment of...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2001.00211.x
更新日期:2001-03-01 00:00:00
abstract::In spatial surveys for estimating the density of objects in a survey region, systematic designs will generally yield lower variance than random designs. However, estimating the systematic variance is well known to be a difficult problem. Existing methods tend to overestimate the variance, so although the variance is g...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2011.01604.x
更新日期:2011-12-01 00:00:00
abstract::Brain evoked potential (EP) data consist of a true response ("signal") and random background activity ("noise"), which are observed over repeated stimulus presentations ("trials"). A signal that changes slowly from trial to trial can be estimated by smoothing across trials and over time within trials. We present a met...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract::The situation considered is the prediction of a future observation from a simple exponential survival distribution in a hierarchical Bayes context. It is shown that when the hyperparameters need to be estimated from the data, a sample reuse approach is superior to maximum likelihood and method of moments estimation pr...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract::ChIP-chip (or ChIP-on-chip) is a technology for isolation and identification of genomic sites occupied by specific DNA-binding proteins in living cells. The ChIP-chip signals can be obtained over the whole genome by tiling arrays, where a peak shape is generally observed around a protein-binding site. In this article,...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2007.00768.x
更新日期:2007-09-01 00:00:00
abstract::Some new scale estimators for the censored two-sample accelerated life model are introduced. They are zeros of some integrated weighted difference between the two cumulative hazard estimators. These estimators are asymptotically normal. The weight is chosen to result in estimators whose asymptotic variances do not inv...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract::This article demonstrates semiparametric maximum likelihood estimation of a nonlinear growth model for fish lengths using imprecisely measured ages. Data on the species corvina reina, found in the Gulf of Nicoya, Costa Rica, consist of lengths and imprecise ages for 168 fish and precise ages for a subset of 16 fish. T...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2002.00448.x
更新日期:2002-06-01 00:00:00
abstract::A common measure in clinical trials and epidemiologic studies is the number of events such as seizures, hospitalizations, or bouts of disease. Frequently, a binary measure of severity for each event is available but is not incorporated in the analysis. This paper proposes methodology for jointly modeling the number of...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::Advances in sequencing technologies and bioinformatics tools have vastly improved our ability to collect and analyze data from complex microbial communities. A major goal of microbiome studies is to correlate the overall microbiome composition with clinical or environmental variables. La Rosa et al. recently proposed ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.13154
更新日期:2020-06-01 00:00:00
abstract::At any age the mean residual life function gives the expected remaining life at that age. Reliabilists and biometricians have found it useful to categorize failure distributions by the monotonicity properties of the mean residual life function. Hollander and Proschan (1975, Biometrika 62, 585-593) have derived tests o...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1983-03-01 00:00:00
abstract::This article develops a variety of influence measures for carrying out perturbation (or sensitivity) analysis to joint models of longitudinal and survival data (JMLS) in Bayesian analysis. A perturbation model is introduced to characterize individual and global perturbations to the three components of a Bayesian model...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2012.01745.x
更新日期:2012-09-01 00:00:00
abstract::A routine challenge is that of making inference on parameters in a statistical model of interest from longitudinal data subject to dropout, which are a special case of the more general setting of monotonely coarsened data. Considerable recent attention has focused on doubly robust (DR) estimators, which in this contex...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2010.01476.x
更新日期:2011-06-01 00:00:00
abstract::For the same number of observations in a small-sample clinical trial with dichotomous outcome, the statistical power associated with a two-sample design, analyzed by Fisher's exact test, is slightly greater than that associated with a matched design, analyzed by McNemar's test, and hence of the matched design, is mono...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1982-09-01 00:00:00
abstract::We present a method for individual and integrative analysis of high dimension, low sample size data that capitalizes on the recurring theme in multivariate analysis of projecting higher dimensional data onto a few meaningful directions that are solutions to a generalized eigenvalue problem. We propose a general framew...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12886
更新日期:2018-12-01 00:00:00
abstract::Eguchi and Matsuura (1990, Biometrics 46, 415-426) noted that the generalized Stevens test statistic for the Hardy-Weinberg law for human leukocyte antigen (HLA) data yields an excessively large value when no double blanks are observed. In this paper, we investigated this aberrant case. The inflated value of the test ...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::Integration of genomic data from multiple platforms has the capability to increase precision, accuracy, and statistical power in the identification of prognostic biomarkers. A fundamental problem faced in many multi-platform studies is unbalanced sample sizes due to the inability to obtain measurements from all the pl...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12587
更新日期:2017-06-01 00:00:00
abstract::In this paper, a group sequential procedure for all-private comparisons of the means of k independent normal populations with a common known variance is proposed. A repeated range test is defined and its critical points are tabulated. The power function is studied and minimum group size needed to achieve a desirable p...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract::Complex issues arise when investigating the association between longitudinal immunologic measures and time to an event, such as time to relapse, in cancer vaccine trials. Unlike many clinical trials, we may encounter patients who are cured and no longer susceptible to the time-to-event endpoint. If there are cured pat...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/1541-0420.00079
更新日期:2003-09-01 00:00:00
abstract::We describe an adaptive Bayesian design for a clinical trial of an experimental treatment for patients with hematologic malignancies who initially received an allogeneic bone marrow transplant but subsequently suffered a disease recurrence. Treatment consists of up to two courses of targeted immunotherapy followed by ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2002.00560.x
更新日期:2002-09-01 00:00:00
abstract::We propose a design strategy for single-arm clinical trials in which the goals are to find a dose of an experimental treatment satisfying both safety and efficacy requirements, treat a sufficiently large number of patients to estimate the rates of these events at the selected dose with a given reliability, and stop th...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract:SUMMARY:A trend test is often employed to analyze ordered categorical data, in which a set of increasing scores is assigned a priori. There is a drawback in this approach, because how to choose a set of scores is not clear. There have been debates on which scores should be used (e.g., Graubard and Korn, 1987, Biometric...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2008.00992.x
更新日期:2008-12-01 00:00:00