Abstract:
:ChIP-chip (or ChIP-on-chip) is a technology for isolation and identification of genomic sites occupied by specific DNA-binding proteins in living cells. The ChIP-chip signals can be obtained over the whole genome by tiling arrays, where a peak shape is generally observed around a protein-binding site. In this article, we describe the ChIP-chip process and present a probability model for ChIP-chip data. We then propose a model-based method for recognizing the peak shapes for the purpose of detecting protein-binding sites. We also investigate the issue of bandwidth in nonparametric kernel smoothing method.
journal_name
Biometricsjournal_title
Biometricsauthors
Zheng M,Barrera LO,Ren B,Wu YNdoi
10.1111/j.1541-0420.2007.00768.xsubject
Has Abstractpub_date
2007-09-01 00:00:00pages
787-96issue
3eissn
0006-341Xissn
1541-0420pii
BIOM768journal_volume
63pub_type
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