Abstract:
:Light deprivation has been found to produce accelerated recovery from severe multimodal neglect induced by unilateral destruction of medial agranular cortex, the rat analog of area 8 in humans. However, neglect in humans is most often produced by destruction of the parietal association cortex. Therefore, the present study examined whether light deprivation would produce accelerated recovery from severe multimodal neglect induced by unilateral destruction of the rodent analog of the parietal association cortex. Subjects received unilateral parietal association cortex lesions, and 4 h after surgery were tested for neglect of visual, tactile, and auditory stimuli. If severe neglect was obtained, subjects experienced either light deprivation, constant light, or a 12:12 light/dark cycle for 48 h. The results indicated that, relative to the other groups, the light deprivation group demonstrated significant accelerated recovery from neglect. Recovery was evident on the first post-light deprivation behavioral test, and was maintained for the 3 weeks of behavioral testing. The results provide further support for the therapeutic effects of light deprivation on neglect induced by cortical lesions when light deprivation is administered in the immediate postoperative period.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Burcham KJ,Corwin JV,Van Vleet TMdoi
10.1016/s0166-4328(97)00100-9subject
Has Abstractpub_date
1998-02-01 00:00:00pages
187-97issue
2eissn
0166-4328issn
1872-7549pii
S0166432897001009journal_volume
90pub_type
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journal_title:Behavioural brain research
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