The effect of 6-OHDA lesions of the lateral septum on schedule-induced polydipsia.

Abstract:

:In this study the relationship between 6-hydroxydopamine lesions of dopaminergic innervation of the lateral septum and schedule-induced polydipsia was examined. Animals with lesions were found to have a significant increase in water intake during a test involving an intermittent schedule of food delivery. Additional experiments with these animals showed that lesions had no effect on: (i) spontaneous drinking, the amount of drinking after 24 h food or water deprivation, water intake following a hypertonic saline challenge; (ii) eating behavior with or without food deprivation; and (iii) spontaneous locomotor activity. This increase in adjunctive behavior is discussed in the light of an enhanced frustrative effect induced by the septal lesions.

journal_name

Behav Brain Res

authors

Taghzouti K,Simon H,Tazi A,Dantzer R,Le Moal M

doi

10.1016/0166-4328(85)90012-9

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

1-8

issue

1

eissn

0166-4328

issn

1872-7549

pii

0166-4328(85)90012-9

journal_volume

15

pub_type

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