Combining electrophysiological and hemodynamic measures of the auditory oddball.

Abstract:

:The neural mechanisms of deviancy and target detection were investigated by combining high density event-related potential (ERP) recordings with functional magnetic resonance imaging (fMRI). ERP and fMRI responses were recorded using the same paradigm and the same subjects. Unattended deviants elicited a mismatch negativity (MMN) in the ERP. In the fMRI data, activations of transverse/superior temporal gyri bilateral were found. Attended deviants generated an MMN followed by an N2/P3b complex. For this condition, fMRI activations in both superior temporal gyri and the neostriatum were found. These activations were taken as neuroanatomical constraints for the localization of equivalent current dipoles. Inverse solutions for dipole orientation provide evidence for significant activation close to Heschl's gyri during deviancy processing in the 110-160-ms time interval (MMN), whereas target detection could be modeled by two dipoles in the superior temporal gyrus between 320 and 380 ms.

journal_name

Psychophysiology

journal_title

Psychophysiology

authors

Opitz B,Mecklinger A,Von Cramon DY,Kruggel F

doi

10.1017/s0048577299980848

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

142-7

issue

1

eissn

0048-5772

issn

1540-5958

journal_volume

36

pub_type

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