Neuroticism, cortisol reactivity, and antibody response to vaccination.

Abstract:

:This study examined whether neuroticism was related to the antibody response to influenza vaccination and whether the relationship was mediated by cortisol reactions to acute laboratory mental stress. Antibody status was assessed at baseline and to a trivalent influenza vaccination in 57 students at 5-week and 5-month follow-up. Neuroticism was also measured at baseline. Cortisol was measured at rest and in response to a pressurized mental arithmetic task. At both follow-ups, higher neuroticism scores were associated with poorer A/Panama antibody response, following adjustment for baseline antibody titer. Higher neuroticism scores were also associated with blunted cortisol reactivity, and blunted cortisol reactivity was associated with poorer A/Panama antibody response, but only at 5 months. However, there was no conclusive evidence that cortisol reactivity mediated the association between neuroticism and antibody response.

journal_name

Psychophysiology

journal_title

Psychophysiology

authors

Phillips AC,Carroll D,Burns VE,Drayson M

doi

10.1111/j.1469-8986.2005.00281.x

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

232-8

issue

2

eissn

0048-5772

issn

1540-5958

pii

PSYP281

journal_volume

42

pub_type

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