Genome-wide scans of genetic variants for psychophysiological endophenotypes: introduction to this special issue of Psychophysiology.

Abstract:

:This special issue addresses the heritability and molecular genetic basis of 17 putative endophenotypes involving resting EEG power, P300 event-related potential amplitude, electrodermal orienting and habituation, antisaccade eye tracking, and affective modulation of the startle eye blink. These measures were collected from approximately 4,900 twins and parents who provided DNA samples through their participation in the Minnesota Twin Family Study. Included are papers that detail the methodology followed, genome-wide association analyses of single nucleotide polymorphisms and genes, analysis of rare variants in the human exome, and a whole genome sequencing study. Also included are 11 articles by leading experts in psychophysiology and genetics that provide perspective and commentary. A final integrative report summarizes findings and addresses issues raised. This introduction provides an overview of the aims and rationale behind these studies.

journal_name

Psychophysiology

journal_title

Psychophysiology

authors

Iacono WG

doi

10.1111/psyp.12340

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

1201-2

issue

12

eissn

0048-5772

issn

1540-5958

journal_volume

51

pub_type

  • Is it important that the mind is in a body? Inhibition and the heart.

    abstract::The hypothesis is advanced that certain inhibitory processes necessarily involve autonomic adjustments. Such adjustments would represent a constraint on information processing imposed by the location of the mind in a body. Evidence is reviewed showing that motoric inhibition is related to a transient delay in heartbea...

    journal_title:Psychophysiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1469-8986.1992.tb01710.x

    authors: Jennings JR

    更新日期:1992-07-01 00:00:00

  • Effects of short-term aerobic training versus CPAP therapy on heart rate variability in moderate to severe OSA patients.

    abstract::We compared the effects of 2-month CPAP or exercise training (ET) therapies on the autonomic balance in moderate to severe obstructive sleep apnea (OSA) through heart rate variability (HRV) analysis. Thirty-nine OSA patients were divided into CPAP (n = 18) and ET (n = 21) groups, being further split into hypertensive ...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/psyp.13771

    authors: Cipriano LHC,Borges YG,Mill JG,Mauad H,Martins de Araújo MT,Gouvea SA

    更新日期:2021-01-22 00:00:00

  • Association between neural reactivity and startle reactivity to uncertain threat in two independent samples.

    abstract::Prior studies indicate that anxiety disorders are associated with heightened sensitivity to uncertain threat (U threat). Individual differences in reactivity to U threat have been measured in the laboratory with two methodologies-startle eyeblink potentiation and fMRI. While startle and fMRI are purported to relate to...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/psyp.12829

    authors: Gorka SM,Lieberman L,Shankman SA,Phan KL

    更新日期:2017-05-01 00:00:00

  • Processing of auditory deviants with changes in one versus two stimulus dimensions.

    abstract::Auditory event-related potentials (ERPs) in response to 50-ms tones were recorded from the human scalp. A standard stimulus (p = .88) and three different deviants were randomly presented via earphones. There were two one-dimensional deviants (one frequency and one location deviant) and one two-dimensional deviant, wit...

    journal_title:Psychophysiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1469-8986.1995.tb03406.x

    authors: Schröger E

    更新日期:1995-01-01 00:00:00

  • Differential conditioning to facial emotional expressions: effects of hemispheric asymmetries and CS identification.

    abstract::Previous studies on aversive learning have suggested a right hemispheric advantage for eliciting autonomic reactions to a masked conditioned facial stimulus (CS) depicting anger. The present study investigated the effects of visual field (VF), stimulus awareness, and emotional valence of the CSs on indicators of condi...

    journal_title:Psychophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1111/1469-8986.3860936

    authors: Peper M,Karcher S

    更新日期:2001-11-01 00:00:00

  • Cardiovascular patterns associated with appetitive and defensive activation during affective picture viewing.

    abstract::In this study we assessed blood pressure (BP), heart rate (HR), stroke volume (SV), cardiac output (CO), and total peripheral resistance (TPR) in response to 13 picture series in 37 participants in order to investigate their hemodynamic response associated with activation of the appetitive and defensive motivational s...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8986.2009.00953.x

    authors: Gomez P,Danuser B

    更新日期:2010-05-01 00:00:00

  • Affective modulation and prepulse inhibition of startle among undergraduates high and low in behavioral inhibition and approach.

    abstract::Valence modulation and prepulse inhibition of startle were examined among 80 undergraduates scoring in the upper and lower quartiles of self-report measures of behavioral inhibition (BIS) and behavioral approach (BAS). Participants viewed a series of pleasant, neutral, and unpleasant pictures. Acoustic startle probes ...

    journal_title:Psychophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1111/1469-8986.00013

    authors: Hawk LW Jr,Kowmas AD

    更新日期:2003-01-01 00:00:00

  • ERP correlates of valence asymmetry during incentive anticipation.

    abstract::The stimulus-preceding negativity (SPN) is a reliable index of incentive anticipation. However, it remains controversial whether the anticipatory process indexed by the SPN is modulated by incentive valence. The present study investigated the effect of valence on the SPN in a gambling task that required participants t...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/psyp.13213

    authors: Li Q,Xu J,Chen W,Mu Z,An T,Zheng Y

    更新日期:2018-11-01 00:00:00

  • ERP correlates of complex human decision making in a gambling paradigm: detection and resolution of conflict.

    abstract::The present event-related potential study investigated the correlates of decision making in relation to the amount of response conflict. In a gambling paradigm, response conflict was introduced by giving participants the option to either gamble or pass. Second, the odds and gains in each trial were manipulated to make...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8986.2008.00678.x

    authors: Mennes M,Wouters H,van den Bergh B,Lagae L,Stiers P

    更新日期:2008-09-01 00:00:00

  • A comparison of field and laboratory polygraphs in the detection of deception.

    abstract::This study compared the effectiveness of field and laboratory polygraphs in discriminating guilty and innocent subjects tested using the Control Question Technique (CQT). Subjects were 48 prisoners examined regarding a mock theft in a peer threat context; physiological responses were recorded simultaneously on a Lafay...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8986.1991.tb01006.x

    authors: Patrick CJ,Iacono WG

    更新日期:1991-11-01 00:00:00

  • Social determinants of cardiovascular reactivity: effects of incentive to exert influence and evaluative threat.

    abstract::The effects on cardiovascular reactivity of incentive to influence the judgements of the experimenter and the threat of social evaluation were examined in a sample of 60 male and 60 female undergraduates. Participants either were guaranteed $5.00 to prepare and deliver a brief speech or were told that the money was co...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8986.1997.tb02417.x

    authors: Smith TW,Nealey JB,Kircher JC,Limon JP

    更新日期:1997-01-01 00:00:00

  • Semantic and affective processing in psychopaths: an event-related potential (ERP) study.

    abstract::We tested the hypothesis that psychopathy is associated with abnormal processing of semantic and affective verbal information. In Task 1, a lexical decision task, and in Task 2, a word identification task, participants responded faster to concrete than to abstract words. In Task 2, psychopaths made more errors identif...

    journal_title:Psychophysiology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Kiehl KA,Hare RD,McDonald JJ,Brink J

    更新日期:1999-11-01 00:00:00

  • Investigating the age-related "anterior shift" in the scalp distribution of the P3b component using principal component analysis.

    abstract::An age-related "anterior shift" in the distribution of the P3b is often reported. Temporospatial principal component analysis (PCA) was used to investigate the basis of this observation. ERPs were measured in young and old adults during a visual oddball task. PCA revealed two spatially distinct factors in both age gro...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/psyp.12206

    authors: Alperin BR,Mott KK,Rentz DM,Holcomb PJ,Daffner KR

    更新日期:2014-07-01 00:00:00

  • Vicarious pain responders and emotion: Evidence for distress rather than mimicry.

    abstract::Up to a third of the population experiences pain when seeing another in pain. The mechanisms underlying such vicarious sensory experiences are thought to reflect hyperactive mirror systems (threshold theory) or dysfunctional processing and representation of oneself versus others (self/other theory). This study investi...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/psyp.12865

    authors: Young KA,Gandevia SC,Giummarra MJ

    更新日期:2017-07-01 00:00:00

  • Event-related potentials reveal the effect of prior knowledge on competition for representation and attentional capture.

    abstract::Objects compete for representation in our limited capacity visual system. We examined how this competition is influenced by top-down knowledge using event-related potentials. Competition was manipulated by presenting visual search arrays in which the target or distractor was the only color singleton compared to displa...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/psyp.12154

    authors: Hilimire MR,Corballis PM

    更新日期:2014-01-01 00:00:00

  • The impact of emotion on respiratory-related evoked potentials.

    abstract::Emotion influences the perception of respiratory sensations, although the specific mechanism underlying this modulation is not yet clear. We examined the impact of viewing pleasant, neutral, and unpleasant affective pictures on the respiratory-related evoked potential (RREP) elicited by a short inspiratory occlusion i...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8986.2009.00956.x

    authors: Von Leupoldt A,Vovk A,Bradley MM,Keil A,Lang PJ,Davenport PW

    更新日期:2010-05-01 00:00:00

  • The influence of semantic and phonological factors on syntactic decisions: an event-related brain potential study.

    abstract::During language production and comprehension, information about a word's syntactic properties is sometimes needed. While the decision about the grammatical gender of a word requires access to syntactic knowledge, it has also been hypothesized that semantic (i.e., biological gender) or phonological information (i.e., s...

    journal_title:Psychophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1111/1469-8986.00105

    authors: Schiller NO,Münte TF,Horemans I,Jansma BM

    更新日期:2003-11-01 00:00:00

  • Affective modulation of nociception at spinal and supraspinal levels.

    abstract::This study was designed to examine the effect of emotion on the nociceptive flexion reflex and pain ratings. To do so, 28 participants viewed pictures varying in emotional valence (unpleasant, neutral, pleasant) and electric stimulations were delivered during and in between pictures. Biceps femoris EMG resulting from ...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8986.2005.00313.x

    authors: Rhudy JL,Williams AE,McCabe KM,Nguyen MA,Rambo P

    更新日期:2005-09-01 00:00:00

  • Can arterial elasticity be estimated from heart rate variability response to paced 0.066 Hz sighing?

    abstract::Arterial elasticity is an important indicator of risk for cardiovascular disease (CVD). It is influenced by both gradual vessel wall damage due to aging and disease and vascular tone that responds, at the moment, to system loading. Measuring changes in arterial elasticity are critical to early detection of CVD but can...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/psyp.13552

    authors: Vaschillo B,Vaschillo EG

    更新日期:2020-08-01 00:00:00

  • Laser-evoked potentials to noxious stimulation during hypnotic analgesia and distraction of attention suggest different brain mechanisms of pain control.

    abstract::Psychological accounts of hypnosis have hypothesized that hypnosis and attention might share similar mechanisms and that hypnosis simply represents an extensive state of reduced attention. This assumption implies that reports of pain and electrocortical brain responses to painful stimulation should be similarly reduce...

    journal_title:Psychophysiology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Friederich M,Trippe RH,Ozcan M,Weiss T,Hecht H,Miltner WH

    更新日期:2001-09-01 00:00:00

  • Head magnetomyography (hMMG): A novel approach to monitor face and whole head muscular activity.

    abstract::Muscular activity recording is of high basic science and clinical relevance and is typically achieved using electromyography (EMG). While providing detailed information about the state of a specific muscle, this technique has limitations such as the need for a priori assumptions about electrode placement and difficult...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/psyp.13507

    authors: Barchiesi G,Demarchi G,Wilhelm FH,Hauswald A,Sanchez G,Weisz N

    更新日期:2020-03-01 00:00:00

  • Long-term exposure to noise impairs cortical sound processing and attention control.

    abstract::Long-term exposure to noise impairs human health, causing pathological changes in the inner ear as well as other anatomical and physiological deficits. Numerous individuals are daily exposed to excessive noise. However, there is a lack of systematic research on the effects of noise on cortical function. Here we report...

    journal_title:Psychophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1469-8986.2004.00244.x

    authors: Kujala T,Shtyrov Y,Winkler I,Saher M,Tervaniemi M,Sallinen M,Teder-Sälejärvi W,Alho K,Reinikainen K,Näätänen R

    更新日期:2004-11-01 00:00:00

  • Monitoring retrieval from long-term memory by slow event-related brain potentials.

    abstract::Slow event-related brain potentials of nine subjects were recorded in an experimentally controlled long-term memory retrieval task (the Fan paradigm) from electrode sites F3, Fz, F4, Cz, P3, Pz, and P4. In all retrieval conditions, a very pronounced DC-like negative potential appeared over the left frontal cortex. Thi...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8986.1993.tb01730.x

    authors: Rösler F,Heil M,Glowalla U

    更新日期:1993-03-01 00:00:00

  • Selection and preparation of hand and foot movements: Cz activity as a marker of limb system preparation.

    abstract::Event-related potentials were used to examine the preparation of hand and foot responses in tasks using both limb systems. As in tasks using only one system, opposite lateralized readiness potentials were observed for hand and foot responses (Experiment 1). Furthermore, movement-related activity at Cz was more positiv...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8986.2011.01338.x

    authors: Miller J

    更新日期:2012-05-01 00:00:00

  • The antisaccade task as a research tool in psychopathology: a critical review.

    abstract::The antisaccade task is a measure of volitional control of behavior sensitive to fronto-striatal dysfunction. Here we outline important issues concerning antisaccade methodology, consider recent evidence of the cognitive processes and neural mechanisms involved in task performance, and review how the task has been app...

    journal_title:Psychophysiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1469-8986.2006.00403.x

    authors: Hutton SB,Ettinger U

    更新日期:2006-05-01 00:00:00

  • On why not to rush older adults--relying on reactive cognitive control can effectively reduce errors at the expense of slowed responses.

    abstract::According to the dual-mechanisms of cognitive control framework (DMC), older adults rely predominantly on reactive as opposed to proactive control. As a result, we expected elevated response conflict for older relative to younger adults with increasing task difficulty. Response-locked ERP activity was examined separat...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1469-8986.2009.00973.x

    authors: Czernochowski D,Nessler D,Friedman D

    更新日期:2010-07-01 00:00:00

  • Electrophysiological evidence for altered early cerebral somatosensory signal processing in schizophrenia.

    abstract::Various studies have indicated an impairment of sensory signal processing in schizophrenic patients. Anatomical and functional imaging studies have indicated morphological and metabolic abnormalities in the thalamus in schizophrenia. Other results give evidence for an additional role of cortical dysfunction in sensory...

    journal_title:Psychophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1111/1469-8986.2004.00163.x

    authors: Waberski TD,Norra C,Kawohl W,Thyerlei D,Hock D,Klostermann F,Curio G,Buchner H,Hoff P,Gobbelé R

    更新日期:2004-05-01 00:00:00

  • Are fingers special? Evidence about movement preparation from event-related brain potentials.

    abstract::Ulrich, Leuthold, and Sommer (1998) suggested that movement preparation at the level of the motor cortex, as indexed by the lateralized readiness potential (LRP), proceeds in a strongly hierarchical fashion, where parameters other than response hand are prepared only if all the movement parameters are known. These con...

    journal_title:Psychophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1111/1469-8986.00002

    authors: Wild-Wall N,Sangals J,Sommer W,Leuthold H

    更新日期:2003-01-01 00:00:00

  • Regression-based estimation of ERP waveforms: I. The rERP framework.

    abstract::ERP averaging is an extraordinarily successful method, but can only be applied to a limited range of experimental designs. We introduce the regression-based rERP framework, which extends ERP averaging to handle arbitrary combinations of categorical and continuous covariates, partial confounding, nonlinear effects, and...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/psyp.12317

    authors: Smith NJ,Kutas M

    更新日期:2015-02-01 00:00:00

  • Markers of stress and inflammation as potential mediators of the relationship between exercise and depressive symptoms: findings from the TRAILS study.

    abstract::The hypothalamic-pituitary-adrenal axis, autonomic nervous system, and immune system have been proposed to underlie the antidepressant effect of exercise. Using a population sample of 715 adolescents, we examined whether pathways from exercise to affective and somatic symptoms of depression were mediated by these puta...

    journal_title:Psychophysiology

    pub_type: 杂志文章

    doi:10.1111/psyp.12329

    authors: Booij SH,Bos EH,de Jonge P,Oldehinkel AJ

    更新日期:2015-03-01 00:00:00