Selective inhibition of phospholipases by atiprimod, a macrophage targeting antiarthritic compound.

abstract：:Chemotherapy is one of the major strategies for cancer treatment. Several antineoplastic drugs including vinorelbine (VRB) are commonly intravenously infused and liable to cause serious phlebitis. The therapeutic drugs for preventing this complication are limited. In this study, the mechanism of baicalein (BCN) was in...

journal_title：Toxicology and applied pharmacology

authors： Ge GF,Shi WW,Yu CH,Jin XY,Zhang HH,Zhang WY,Wang LC,Yu B

更新日期：2017-03-01 00:00:00

abstract：:Recently, the FDA approved the medical use of oral pyridostigmine as prophylactic treatment of possible nerve agent exposure: the concept is to block the cholinesterase transitorily using the carbamate (pyridostigmine) in order to deny access to the active site of the enzyme to the irreversible inhibitor (nerve agent)...

journal_title：Toxicology and applied pharmacology

authors： Petroianu GA,Hasan MY,Nurulain SM,Arafat K,Sheen R,Nagelkerke N

更新日期：2007-03-01 00:00:00

abstract：:A comparative study was undertaken in order to assess the hematotoxic effects of hydroquinone (HQ), 1,4-benzoquinone (BQ), and doxorubicin (DX) on mouse and human bone marrow (BM) cells. Initial experiments indicated that the inhibitory effects of near-ambient pO2 and HQ on granulocyte/macrophage colony-stimulating fa...

journal_title：Toxicology and applied pharmacology

authors： Colinas RJ,Burkart PT,Lawrence DA

更新日期：1994-11-01 00:00:00

abstract：:Mycotoxin citrinin (CTN) is commonly found in foods and feeds that are contaminated/inoculated with Penicillium, Aspergillus and Monascus species. The exposure of human embryonic kidney (HEK293) and HeLa cells to CTN resulted in a dose-dependent increase in the phosphorylation of two major mitogen-activated protein ki...

journal_title：Toxicology and applied pharmacology

authors： Chang CH,Yu FY,Wang LT,Lin YS,Liu BH

更新日期：2009-06-15 00:00:00

abstract：:Earlier, we reported that chronic cadmium (Cd)-exposure to prostate epithelial (RWPE-1) cells causes defective autophagy, which leads to the transformation of a malignant phenotype in both in vitro and in vivo models. However, the upstream events responsible for defective autophagy are yet to be delineated. The presen...

journal_title：Toxicology and applied pharmacology

authors： Kolluru V,Tyagi A,Chandrasekaran B,Ankem M,Damodaran C

更新日期：2019-06-15 00:00:00

abstract：:The Ah locus encodes a cytosolic receptor that regulates the induction of certain drug-metabolizing enzymes by polycyclic aromatic hydrocarbons such as benzo[a]pyrene. Some inbred mouse strains such as C57BL/6N have the high-affinity Ah receptor (Ahb/Ahb), others such as DBA/2N, the poor-affinity receptor (Ahd/Ahd). P...

journal_title：Toxicology and applied pharmacology

authors： Legraverend C,Harrison DE,Ruscetti FW,Nebert DW

更新日期：1983-09-30 00:00:00

abstract：:Geogenic dust from arid environments is a possible inhalation hazard for humans, especially when using off-road vehicles that generate significant dust. This study focused on immunotoxicological and neurotoxicological effects following subacute exposure to geogenic dust generated from sediments in the Nellis Dunes Rec...

journal_title：Toxicology and applied pharmacology

authors： DeWitt J,Buck B,Goossens D,Hu Q,Chow R,David W,Young S,Teng Y,Leetham-Spencer M,Murphy L,Pollard J,McLaurin B,Gerads R,Keil D

更新日期：2016-08-01 00:00:00

abstract：:Occupational exposure to nickel (Ni), chromium (Cr), and arsenic (As) containing compounds has been associated with lung cancer and other adverse health effects. Their carcinogenic properties may be attributable in part, to activation and/or repression of gene expression induced by changes in the DNA methylation statu...

journal_title：Toxicology and applied pharmacology

authors： Zhou X,Li Q,Arita A,Sun H,Costa M

更新日期：2009-04-01 00:00:00

abstract：:PCBs are neurotoxic compounds that have a known effect on the dopaminergic system in the brain. In a previous work it was established that PCBs are potent inhibitors of the uptake of dopamine into rat brain synaptic vesicles. In this work we further investigated the vesicular dopamine uptake in response to different P...

journal_title：Toxicology and applied pharmacology

authors： Mariussen E,Andersson PL,Tysklind M,Fonnum F

更新日期：2001-09-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is teratogenic in mice, inducing cleft palate and hydronephrosis at doses which are not overtly maternally toxic or embryotoxic. After TCDD exposure the palatal shelves of normal size come into contact, but fail to fuse due to altered differentiation of the medial epithelial ...

journal_title：Toxicology and applied pharmacology

authors： Abbott BD,Birnbaum LS

更新日期：1990-12-01 00:00:00

abstract：:Organic UV filters including benzophenone-3 (BP-3) are widely used to protect humans and materials from damage by UV irradiation. Despite the environmental occurrence of BP-3 in the aquatic environment, little is known about its effects and modes of action. In the present study we assess molecular and physiological ef...

journal_title：Toxicology and applied pharmacology

authors： Blüthgen N,Zucchi S,Fent K

更新日期：2012-09-01 00:00:00

abstract：:Nuclear receptors (NRs) are key regulators of human health and constitute a relevant target for medicinal chemistry applications as well as for toxicological risk assessment. Several open databases dedicated to small molecules that modulate NRs exist; however, depending on their final aim (i.e., adverse effect assessm...

journal_title：Toxicology and applied pharmacology

authors： Valsecchi C,Grisoni F,Motta S,Bonati L,Ballabio D

更新日期：2020-11-15 00:00:00

abstract：:Combined exposure of cadmium (Cd) and insulin resistance (IR) might be responsible for subfertility. In the present study, we investigated the effects of Cd in vitro in IR human granulosa cells. Isolated human granulosa cells from control and polycystic ovary syndrome (PCOS) follicular fluid samples were confirmed for...

journal_title：Toxicology and applied pharmacology

authors： Belani M,Shah P,Banker M,Gupta S

更新日期：2016-12-15 00:00:00

abstract：:The transplacental crossover of 14C-2,4,5,2',4',5'-hexachlorobiphenyl (6-CB) from the maternal circulation to the fetal side of the placenta was examined in intact fetuses and following the in situ perfusion of the guinea pig placenta. Fetal, late pregnant, and nonpregnant female guinea pig lipoprotein profiles and th...

journal_title：Toxicology and applied pharmacology

authors： Ring BJ,Seitz KR,Vodicnik MJ

更新日期：1988-10-01 00:00:00

abstract：:The glutathione precursor N-acetyl-L-cysteine (NAC) is currently being tested on Parkinson's patients for its neuroprotective properties. Our studies have shown that NAC can elicit protection in glutathione-independent manners in vitro. Thus, the goal of the present study was to establish an animal model of NAC-mediat...

journal_title：Toxicology and applied pharmacology

authors： Nouraei N,Zarger L,Weilnau JN,Han J,Mason DM,Leak RK

更新日期：2016-04-01 00:00:00

abstract：:Purified fetal bovine serum acetylcholinesterase (FBS AChE) and horse serum butyrylcholinesterase (BChE) were successfully used as single pretreatment drugs for the prevention of pinacolyl methylphosphonofluoridate (soman) toxicity in nonhuman primates. Eight rhesus monkeys, trained to perform Primate Equilibrium Plat...

journal_title：Toxicology and applied pharmacology

authors： Wolfe AD,Blick DW,Murphy MR,Miller SA,Gentry MK,Hartgraves SL,Doctor BP

更新日期：1992-12-01 00:00:00

abstract：:Chelating agents commonly used in therapy of heavy metal intoxication alter the levels of essential metals in liver, kidneys, and serum. Induction of metallothionein synthesis in liver occurs following exposure to a variety of chemical and environmental insults and, in some cases, has been attributed to enhanced hepat...

journal_title：Toxicology and applied pharmacology

authors： Goering PL,Tandon SK,Klaassen CD

更新日期：1985-09-30 00:00:00

abstract：:p-Aminophenol causes necrosis of the pars recta of the proximal tubules in rats, and its nephrotoxicity may be due to glutathione-dependent bioactivation reactions. We have investigated the hepatic metabolism of p-aminophenol in Wistar rats and the cytotoxicity of formed glutathione S-conjugates in rat renal epithelia...

journal_title：Toxicology and applied pharmacology

authors： Klos C,Koob M,Kramer C,Dekant W

更新日期：1992-07-01 00:00:00

abstract：:Juglone is a phenolic compound used in popular medicine as a phytotherapic to treat inflammatory and infectious diseases. However, it also acts as an uncoupler of oxidative phosphorylation in isolated liver mitochondria and, thus, may interfere with the hepatic energy metabolism. The purpose of this work was to evalua...

journal_title：Toxicology and applied pharmacology

authors： Saling SC,Comar JF,Mito MS,Peralta RM,Bracht A

更新日期：2011-12-15 00:00:00

abstract：:Exposure to cadmium (Cd) impairs renal transport systems for glucose, amino acids, phosphate, and dicarboxylates. To investigate if these changes are directly related to a Cd binding to the renal brush-border membrane, Cd binding and the Na+-dependent uptakes of d-glucose, l-alanine, phosphate, and succinate were dete...

journal_title：Toxicology and applied pharmacology

authors： Ahn DW,Kim YM,Kim KR,Park YS

更新日期：1999-02-01 00:00:00

abstract：:The present work evaluates the cytotoxic, genotoxic, and antimutagenic effects of Phyllanthus orbicularis (plant of genus Phyllantus) aqueous extract in Chinese hamster ovary (CHO) cells. P. orbicularis aqueous extracts are used in Cuban traditional medicine for their antiviral activity against Hepatitis B virus and A...

journal_title：Toxicology and applied pharmacology

authors： Sànchez-Lamar A,Fiore M,Cundari E,Ricordy R,Cozzi R,De Salvia R

更新日期：1999-12-15 00:00:00

abstract：:The effect of non-steroidal anti-inflammatory drugs (NSAIDs) on ion channels has been widely studied in several cell models, but less is known about their modulatory mechanisms. In this report, the effect of mefenamic acid on voltage-activated transient outward K(+) current (I(A)) in cultured rat cerebellar granule ce...

journal_title：Toxicology and applied pharmacology

authors： Zhang M,Shi WJ,Fei XW,Liu YR,Zeng XM,Mei YA

更新日期：2008-02-01 00:00:00

abstract：:Reported similarities in the acute toxic effects of 1,2-dibromo-3-chloropropane (DBCP), 3-chloro-1,2-propaneoxide (epichlorohydrin, ECH), 3-chloro-1,2-propanediol (alphachlorohydrin, ACH), and oxalic acid (OA) have been suggested as presumptive evidence that the metabolism of DBCP to OA, via ECH and ACH, is the cause ...

journal_title：Toxicology and applied pharmacology

authors： Kluwe WM,Gupta BN,Lamb JC 4th

更新日期：1983-08-01 00:00:00

abstract：:A cadmium-binding substance with a molecular weight even lower than that of metallothionein was demonstrated on Sephadex G-75 gel filtration chromatography of the soluble fractions from newborn human and adult rat liver homogenates and adult human hemolysate which were mixed with CdCl2 in vitro. This substance was pur...

journal_title：Toxicology and applied pharmacology

authors： Katoh M,Mizutani N,Keino H,Kashiwamata S

更新日期：1984-03-30 00:00:00

abstract：:The effects of oral exposure to 0, 5, and 25 mg/kg body wt vomitoxin (VT) on cytokine mRNA levels in spleen, Peyer's patches (PP), liver, kidney, and small intestine were evaluated in B6C3F1 mice at 2 and 4 hr postexposure using RT-PCR in conjunction with Southern hybridization analysis. The abundance of mRNAs for sev...

journal_title：Toxicology and applied pharmacology

authors： Azcona-Olivera JI,Ouyang Y,Murtha J,Chu FS,Pestka JJ

更新日期：1995-07-01 00:00:00

abstract：:Trimethyltin (TMT) is a neurotoxicant known to alter auditory function. The present study was designed to compare TMT-induced auditory dysfunction using behavioral, electrophysiological, and anatomical techniques. Adult male Long-Evans hooded rats (n = 9-12/group) were acutely exposed to saline, 3, 5, or 7 mg/kg TMT. ...

journal_title：Toxicology and applied pharmacology

authors： Crofton KM,Dean KF,Ménache MG,Janssen R

更新日期：1990-08-01 00:00:00

abstract：:An accumulation of hydrophobic bile acids is implicated in the pathogenesis of cholestatic liver diseases. In the present study, we determined if hydrophobic bile acid-induced cellular injury compromised hepatocyte glutathione (GSH) status, and if modulating intracellular GSH levels prevented or facilitated bile acid-...

journal_title：Toxicology and applied pharmacology

authors： Gumpricht E,Devereaux MW,Dahl RH,Sokol RJ

更新日期：2000-04-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is characterized by a disturbed pulmonary redox balance associated with inflammation. To restore this balance, antioxidants are often suggested as therapy for IPF but previous clinical trials with these compounds and their precursors have not been successful in the clinic. The exoge...

journal_title：Toxicology and applied pharmacology

authors： Veith C,Drent M,Bast A,van Schooten FJ,Boots AW

更新日期：2017-12-01 00:00:00

abstract：:The UDP glucuronosyltransferases (UGT) of the gastrointestinal (GI) tract have a crucial role in protection against the toxic effects of lipophilic chemicals in the environment. UGTs such as UGT1A7, UGT1A8, and UGT1A10 are exclusively expressed in gastrointestinal tissues, each with a unique tissue distribution patter...

journal_title：Toxicology and applied pharmacology

authors： Gregory PA,Lewinsky RH,Gardner-Stephen DA,Mackenzie PI

更新日期：2004-09-15 00:00:00

abstract：:Intravenous administration of drug-loaded polyalkylcyanoacrylate (PACA) nanoparticles is followed by a rapid uptake by the tissues of the reticuloendothelial system, mainly the liver. Nevertheless, it is so far unknown whether chronic administration of nanoparticles can lead to damage to the liver cells. We have studi...

journal_title：Toxicology and applied pharmacology

authors： Fernandez-Urrusuno R,Fattal E,Porquet D,Feger J,Couvreur P

更新日期：1995-02-01 00:00:00