Function of specific K(+) channels in sustained high-frequency firing of fast-spiking neocortical interneurons.

abstract：:Parallel recording of neuronal activity in the behaving animal is a prerequisite for our understanding of neuronal representation and storage of information. Here we describe the development of micro-machined silicon microelectrode arrays for unit and local field recordings. The two-dimensional probes with 96 or 64 re...

journal_title：Journal of neurophysiology

authors： Csicsvari J,Henze DA,Jamieson B,Harris KD,Sirota A,Barthó P,Wise KD,Buzsáki G

更新日期：2003-08-01 00:00:00

abstract：:When the head is free to move, electrical stimulation in the frontal eye field (FEF) evokes eye and head movements. However, it is unclear whether FEF stimulation-evoked head movements contribute to shifting the line of sight, like visually guided coordinated eye-head gaze shifts. Here we investigated this issue by sy...

journal_title：Journal of neurophysiology

authors： Chen LL

更新日期：2006-06-01 00:00:00

abstract：:Mechanosensory neurons exhibit a wide range of dynamic changes in response, including rapid and slow adaptation. In addition to mechanical factors, electrical processes may also contribute to sensory adaptation. We have investigated adaptation of afferent neurons in the stick insect femoral chordotonal organ (fCO). Th...

journal_title：Journal of neurophysiology

authors： DiCaprio RA,Wolf H,Büschges A

更新日期：2002-11-01 00:00:00

abstract：:When people match an unseen hand to a visual or proprioceptive target, they make both variable and systematic (bias) errors. Variance is a well-established factor in behavior, but the origin and implications of bias, and its connection to variance, are poorly understood. Eighty healthy adults matched their unseen righ...

journal_title：Journal of neurophysiology

authors： Liu Y,Sexton BM,Block HJ

更新日期：2018-05-01 00:00:00

abstract：:Activation of muscarinic receptors and GABA(B) receptors causes presynaptic inhibition of glutamatergic synaptic potentials at excitatory feedback connections in cortical structures. These effects may regulate dynamics in cortical structures, with presynaptic inhibition allowing extrinsic afferent input to dominate du...

journal_title：Journal of neurophysiology

authors： Hasselmo ME,Fehlau BP

更新日期：2001-10-01 00:00:00

abstract：:We have used a computer-based mathematical model of alpha-motoneurons and of group Ia synaptic input to them, based on anatomical and electrophysiological data from the cat spinal cord, in order to examine the effects of variations in neuron size and input resistance and of conductance magnitude and duration on the ge...

journal_title：Journal of neurophysiology

authors： Lev-Tov A,Miller JP,Burke RE,Rall W

更新日期：1983-08-01 00:00:00

abstract：:1. We describe a four-layered neural network (Fig. 1), based on the input organization of a collision signaling neuron in the visual system of the locust, the lobula giant movement detector (LGMD). The 250 photoreceptors ("P" units) in layer 1 are excited by any change in illumination, generated when an image edge pas...

journal_title：Journal of neurophysiology

authors： Rind FC,Bramwell DI

更新日期：1996-03-01 00:00:00

abstract：:1. Neurons (n = 142) were recorded with extracellular micropipettes in the parabrachial (PB) area, in the anesthetized rat, some of them being antidromically driven from the centralis nucleus of the amygdala (Ce). The spontaneous activity of these neurons was low, (10th percentile < median frequency < 90th percentile;...

journal_title：Journal of neurophysiology

authors： Bernard JF,Huang GF,Besson JM

更新日期：1994-05-01 00:00:00

abstract：:1. Extracellular bath application of the selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor KN-62 to hippocampal slices in vitro blocked the induction of long-term depression (LTD) by low-frequency Schaffer collateral stimulation (1 Hz/15 min) of the same concentration as has been shown previously to pre...

journal_title：Journal of neurophysiology

authors： Stanton PK,Gage AT

更新日期：1996-09-01 00:00:00

abstract：:1. "Unmasking" of weak synaptic connections has been suggested as a mechanism for the early changes in cortical topographic maps that follow alterations of sensory activity. For such a mechanism to operate, convergent sensory inputs must already exist in the normal cortex. 2. We tested for topographic and cross-modali...

journal_title：Journal of neurophysiology

authors： Smits E,Gordon DC,Witte S,Rasmusson DD,Zarzecki P

更新日期：1991-09-01 00:00:00

abstract：:The widespread noradrenergic innervation in the brain promotes arousal and learning by molecular mechanisms that remain largely undefined. Recent work shows that the β(2)-adrenergic receptor (β(2)AR) is linked to the AMPA-type glutamate receptor subunit GluA1 via stargazin and PSD-95 (Joiner ML, Lise MF, Yuen EY, Kam ...

journal_title：Journal of neurophysiology

authors： Qian H,Matt L,Zhang M,Nguyen M,Patriarchi T,Koval OM,Anderson ME,He K,Lee HK,Hell JW

更新日期：2012-05-01 00:00:00

abstract：:1. Receptive fields (RFs) of neurons in the primary somatosensory (SI) cortex were defined before, during, and after electrical stimulation of myelinated fibers in the dorsal cutaneous branch of the ulnar nerve in adult pentobarbital sodium-anesthetized cats. 2. This stimulation resulted in an approximately threefold ...

journal_title：Journal of neurophysiology

authors： Recanzone GH,Allard TT,Jenkins WM,Merzenich MM

更新日期：1990-05-01 00:00:00

abstract：:1. Membrane currents of normal and TEA-injected cat lumbar motoneurons were investigated using the technique of somatic voltage clamp. 2. The current-voltage (I-V) relation of healthy motoneurons contains a region of negative slope conductance caused by a persistent inward current component (Ii). In the most striking ...

journal_title：Journal of neurophysiology

authors： Schwindt PC,Crill WE

更新日期：1980-06-01 00:00:00

abstract：:We explored how contour information in primary visual cortex might be embedded in the simultaneous activity of multiple cells recorded with a 100-electrode array. Synchronous activity in cat visual cortex was more selective and predictable in discriminating between drifting grating and concentric ring stimuli than cha...

journal_title：Journal of neurophysiology

authors： Samonds JM,Zhou Z,Bernard MR,Bonds AB

更新日期：2006-04-01 00:00:00

abstract：:There are many theories on the purpose of neural adaptation, but evidence remains elusive. Here, we discuss the recent work by Benucci et al. (Nat Neurosci 16: 724-729, 2013), who measured for the first time the immediate effects of adaptation on the overall activity of a neuronal population. These measurements confir...

journal_title：Journal of neurophysiology

authors： Haak KV,Fast E,Baek Y,Mesik J

更新日期：2014-08-01 00:00:00

abstract：:1. Two hundred and twenty-one spinothalamic tract (STT) neurons in the lumbar spinal cord of anesthetized monkeys were studied. The majority of the recordings were in laminae IV-VI. Thirteen of these neurons were intracellularly injected with horseradish peroxidase and histologically reconstructed. 2. A standard serie...

journal_title：Journal of neurophysiology

authors： Surmeier DJ,Honda CN,Willis WD Jr

更新日期：1988-03-01 00:00:00

abstract：:Second-order vestibular neurons (2 degrees VN) were identified in the isolated frog brain by the presence of monosynaptic excitatory postsynaptic potentials (EPSPs) after separate electrical stimulation of individual vestibular nerve branches. Combinations of one macular and the three semicircular canal nerve branches...

journal_title：Journal of neurophysiology

authors： Straka H,Holler S,Goto F

更新日期：2002-11-01 00:00:00

abstract：:Ca2+ currents in dorsal unpaired median (DUM) neurons isolated from the fifth abdominal ganglion of the cockroach Periplaneta americana were investigated with the whole cell patch-clamp technique. On the basis of kinetic and pharmacological properties, two different Ca2+ currents were separated in these cells: mid/low...

journal_title：Journal of neurophysiology

authors： Wicher D,Penzlin H

更新日期：1997-01-01 00:00:00

abstract：:Gamma-aminobutyric acid type A (GABAA) receptors expressed within the medial preoptic area (mPOA) are known to play a critical role in regulating sexual and neuroendocrine functions. In the rat brain, high levels of expression of the gamma1 subunit mRNA of the GABAA receptor are restricted to a limited number of regio...

journal_title：Journal of neurophysiology

authors： Nett ST,Jorge-Rivera JC,Myers M,Clark AS,Henderson LP

更新日期：1999-01-01 00:00:00

abstract：:When a movement results in error, the nervous system amends the motor commands that generate the subsequent movement. Here we show that this adaptation depends not just on error, but also on passage of time between the two movements. We observed that subjects learned a reaching task faster, i.e., with fewer trials, wh...

journal_title：Journal of neurophysiology

authors： Huang VS,Shadmehr R

更新日期：2007-06-01 00:00:00

abstract：:1. Whole cell patch-clamp techniques, combined with direct visualization of neurons, were used to study voltage-dependent potassium currents in layer 1 neurons and layer II/III pyramidal cells. 2. In the presence of tetrodotoxin, step depolarizations evoked an outward current. This current had a complex waveform and a...

journal_title：Journal of neurophysiology

authors： Zhou FM,Hablitz JJ

更新日期：1996-08-01 00:00:00

abstract：:The abilities of humans to discriminate the softness of rubber objects of differing compliance with a hand-held tool (a stylus) was measured under experimental conditions that differed as to how the tool was used and the kind of sensory information available. When the subject actively tapped or pressed the compliant o...

journal_title：Journal of neurophysiology

authors： LaMotte RH

更新日期：2000-04-01 00:00:00

abstract：:Serotonin [5-hydroxytryptamine (5-HT)] is a conspicuous neuromodulator of sensory-motor networks that affects a variety of neurons at different levels of the network hierarchy. Because of its many possible targets, it has been difficult to obtain a comprehensive picture of how 5-HT achieves its final modulatory output...

journal_title：Journal of neurophysiology

authors： Calviño MA,Iscla IR,Szczupak L

更新日期：2005-05-01 00:00:00

abstract：:Neurons in the silkmoth antennal lobe (AL) are well characterized in terms of their morphology and odor-evoked firing activity. However, their intrinsic electrical properties including voltage-gated ionic currents and synaptic connectivity remain unclear. To address this, whole cell current- and voltage-clamp recordin...

journal_title：Journal of neurophysiology

authors： Tabuchi M,Dong L,Inoue S,Namiki S,Sakurai T,Nakatani K,Kanzaki R

更新日期：2015-11-01 00:00:00

abstract：:The whole cell patch-clamp technique in combination with the slice preparation was used to investigate the electrophysiological properties of pigeon semicircular canal sensory and supporting cells. These properties were also characterized in regenerating neuroepithelia of pigeons preinjected with streptomycin to kill ...

journal_title：Journal of neurophysiology

authors： Masetto S,Correia MJ

更新日期：1997-10-01 00:00:00

abstract：:1. To characterize the temporal dynamic responses of ganglion cells and to define the possible inputs giving rise to their responses in catfish retina, we recorded the ganglion cell responses evoked by 1) a step of light presented in the dark, 2) an incremental and decremental step from a background illumination, and ...

journal_title：Journal of neurophysiology

authors： Sakai HM,Naka K

更新日期：1987-12-01 00:00:00

abstract：:During object manipulation, grip force is coordinated with load force, which is primarily determined by object kinematics. Proximal arm kinematics may affect grip force control, as proximal segment motion could affect control of distal hand muscles via biomechanical and/or neural pathways. The aim of this study was to...

journal_title：Journal of neurophysiology

authors： Vermillion BC,Lum PS,Lee SW

更新日期：2015-10-01 00:00:00

abstract：:The cholinergic system is critically involved in synaptic models of learning and memory by enhancing dendritic [Ca(2+)](i) signals. Diffuse cholinergic innervation suggests subcellular modulation of membrane currents and Ca(2+) signals. Here we use ion-selective microelectrodes to study spread of carbachol (CCh) after...

journal_title：Journal of neurophysiology

authors： Egorov AV,Gloveli T,Müller W

更新日期：1999-10-01 00:00:00

abstract：:The grip force applied to maintain grasp of a handheld object has been typically reported as tightly coupled to the load force exerted by the object as it is actively manipulated, occurring proportionally and consistently in phase with changes in load force. However, continuous grip force-load force coupling breaks do...

journal_title：Journal of neurophysiology

authors： Grover FM,Schwab SM,Silva PL,Lorenz T,Riley MA

更新日期：2019-12-01 00:00:00

abstract：:Recognition of sound patterns must be largely independent of level and of masking or jamming background sounds. Auditory patterns of relevance in numerous environmental sounds, species-specific vocalizations and speech are frequency modulations (FM). Level-dependent activation of the human auditory cortex (AC) in resp...

journal_title：Journal of neurophysiology

authors： Brechmann A,Baumgart F,Scheich H

更新日期：2002-01-01 00:00:00