In vitro evaluation of erythromycin in chloroquine resistant brazilian P. falciparum freshly isolates: modulating effect and antimalarial activity evidence.

Abstract:

:Erythromycin, a reversal agent in multidrug-resistant cancer, was assayed in chloroquine resistance modulation. The in vitro microtechnique for drug susceptibility was employed using two freshly isolates of Plasmodium falciparum from North of Brazil. The antimalarial effect of the drug was confirmed, with an IC50 estimates near the usual antimicrobial therapy concentration, and a significant statistical modulating action was observed for one isolate.

authors

Menezes CM,Kirchgatter K,Di Santi SM,Savalli C,Monteiro FG,Paula GA,Ferreira EI

doi

10.1590/s0036-46651999000400009

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

249-53

issue

4

eissn

0036-4665

issn

1678-9946

pii

S0036-4665(99)04100409

journal_volume

41

pub_type

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