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Response to treatment in minor and major depression: results of a double-blind comparative study with paroxetine and maprotiline.

Abstract：

:Several concepts of minor depression in the sense of acute but less severe symptomatology than major depression have been proposed in the literature, but currently none of them is generally accepted. For the treatment of these conditions, only few recommendations based on empirical data are available. We conducted a randomized double-blind multicentre study in depressed outpatients comparing paroxetine and maprotiline in both patients with minor (n = 245) and major depression (n = 298). For the diagnosis, Research Diagnostic Criteria were used in a modified version. Two response criteria were applied: a reduction of 50% or more in total HAMD-17 scores from baseline (criterion 1), and a reduction of the HAMD-17 total score to 9 points or less (criterion 2). A completer and an endpoint analysis was performed. For patients with minor depression, remarkably high response rates were found for paroxetine (criterion 1: 90.9% completer, 82.1% endpoint; criterion 2: 89.1% completer, 82.4% endpoint) while the respective rates for maprotiline tended to be lower (criterion 1: 80.4% completer, 71.4% endpoint; criterion 2: 84.9% completer; 76.1% endpoint). Response rates in patients with major depression were for paroxetine: criterion 1: 74.3% completer, 62.8% endpoint; criterion 2: 76.4% completer, 65.2% endpoint; and for maprotiline: criterion 1:82.4% completer, 68.5% endpoint; criterion 2: 80.6% completer; 66.0% endpoint, which resembles rates reported from previous antidepressant trials. Both drugs were generally well tolerated. Though no placebo control was carried out, our results suggest that minor depression is a disorder that is very likely to respond to antidepressant pharmacotherapy with paroxetine, but also with maprotiline at a favourable risk/benefit ratio.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Szegedi A,Wetzel H,Angersbach D,Philipp M,Benkert O

doi

10.1016/s0165-0327(97)00072-4

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

167-78

issue

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(97)00072-4

journal_volume

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

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Response to treatment in minor and major depression: results of a double-blind comparative study with paroxetine and maprotiline.