Laser-activated solid protein bands for peripheral nerve repair: an vivo study.

Abstract:

BACKGROUND AND OBJECTIVE:Severed tibial nerves in rats were repaired using a novel technique, utilizing a semiconductor diode-laser-activated protein solder applied longitudinally across the join. Welding was produced by selective laser denaturation of solid solder bands containing the dye indocyanine green. STUDY DESIGN/MATERIALS AND METHODS:An in vivo study, using 48 adult male Wistar rats, compared conventional microsuture-repaired tibial nerves with laser solder-repaired nerves. Nerve repairs were characterised immediately after surgery and after 3 months. RESULTS:Successful regeneration with average compound muscle action potentials of 2.5 +/- 0.5 mV and 2.7 +/- 0.3 mV (mean and standard deviation) was demonstrated for the laser-soldered nerves and the sutured nerves, respectively. Histopathology confirmed comparable regeneration of axons in laser- and suture-operated nerves. CONCLUSION:The laser-based nerve repair technique was easier and faster than microsuture repair, minimising manipulation damage to the nerve.

journal_name

Lasers Surg Med

authors

Lauto A,Trickett R,Malik R,Dawes JM,Owen ER

doi

10.1002/(sici)1096-9101(1997)21:2<134::aid-lsm4>3.

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

134-41

issue

2

eissn

0196-8092

issn

1096-9101

pii

10.1002/(SICI)1096-9101(1997)21:2<134::AID-LSM4>3.

journal_volume

21

pub_type

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