Discrimination of cancerous and healthy colon tissues: A new laser-based method.

Abstract:

BACKGROUND:Femtosecond (fs) Laser Ionisation Mass Spectrometry (fs-LIMS) on colon tissues are described and investigated using ionization/fragmentation processes in details to present a new application in this study. Linear Time of Flight (L-TOF) mass analyzer was utilized to investigate paraffin-embedded human tissue in this study. The effect of fs laser intensity on the spectral characteristics was investigated and interpreted due to mass spectra obtained using 800 nm wavelength with 90 fs pulses at 1 kHz repetition rate. OBJECTIVES:Mass spectra of tissues were recorded from L-TOF system and then analyzed by performing a statistical approach called Principal Component Analysis (PCA). The fs-LIMS method applied is proposed as a new and pioneering technology to analyze tissues using L-TOF system, as a human free fast and reliable intra-operative cancer diagnosis method for guiding surgeon to clean the edges of cancerous tissues to be applied during the surgical operation, for pathological examinations. Fs-LIMS provides some unique diagnosis opportunities to investigate biochemical characteristics of cancerous tissues leading to obtain sensitive, fast, and reliable results. The analysis of tissue is based on distribution of molecular ion (m/z) peaks in low mass region (

journal_name

Lasers Surg Med

authors

Gündoğdu Y,Alptekin H,Karabağlı P,Şahin M,Kilic HŞ

doi

10.1002/lsm.23033

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

363-369

issue

4

eissn

0196-8092

issn

1096-9101

journal_volume

51

pub_type

杂志文章
  • A preclinical model to investigate the role of surgically-induced inflammation in tumor responses to intraoperative photodynamic therapy.

    abstract:OBJECTIVE:Inflammation is a well-known consequence of surgery. Although surgical debulking of tumor is beneficial to patients, the onset of inflammation in injured tissue may impede the success of adjuvant therapies. One marker for postoperative inflammation is IL-6, which is released as a consequence of surgical injur...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/lsm.22934

    authors: Davis RW 4th,Papasavvas E,Klampatsa A,Putt M,Montaner LJ,Culligan MJ,McNulty S,Friedberg JS,Simone CB 2nd,Singhal S,Albelda SM,Cengel KA,Busch TM

    更新日期:2018-07-01 00:00:00

  • Optical coherence tomography as a method to identify parathyroid glands.

    abstract:BACKGROUND AND OBJECTIVE:The identification of parathyroid glands can be a major problem in parathyroid surgery. The purpose of this study was to evaluate the feasibility of optical coherence tomography (OCT) in distinguishing between parathyroid tissue, thyroid tissue, lymph nodes, and adipose tissue. METHODS:Ex vivo...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.22195

    authors: Ladurner R,Hallfeldt KK,Al Arabi N,Stepp H,Mueller S,Gallwas JK

    更新日期:2013-12-01 00:00:00

  • Theramal, mechanical, optical, and morphologic changes in bovine nucleus pulposus induced by Nd:YAG (lambda = 1.32 microm) laser irradiation.

    abstract:UNLABELLED:BACKGROUND AND OBJECTIVE To examine the biophysical effects of photothermal heating on herniated intervertebral discs during laser decompression surgery. STUDY DESIGN/MATERIALS AND METHODS:Ex vivo bovine nucleus pulposus specimens were irradiated with a Nd: YAG laser (lambda = 1.32 microm, 100 seconds expos...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1046

    authors: Choi JY,Tanenbaum BS,Milner TE,Dao XV,Nelson JS,Sobol EN,Wong BJ

    更新日期:2001-01-01 00:00:00

  • MRI guided interstitial laser therapy in a rat malignant glioma model.

    abstract::We have used MR monitoring to guide and evaluate the effects of the Nd:YAG interstitial laser on a well-characterized rat brain tumor model (C6). MRI was used to determine the tumor size, verify the location of the interstitial probe, and evaluate the size and location of the laser-induced lesion during and after trea...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900130502

    authors: el-Ouahabi A,Guttmann CR,Hushek SG,Bleier AR,Dashner K,Dikkes P,Black PM,Jolesz FA

    更新日期:1993-01-01 00:00:00

  • Intense pulsed light and Nd:YAG laser non-ablative treatment of facial rhytids.

    abstract:BACKGROUND AND OBJECTIVE:The aim of this study was to evaluate the efficacy and safety of the intense pulsed light source (IPL) and the Nd:YAG laser in the treatment of facial rhytids. Both systems can be used in a non-ablative manner and cause a dermal wound. This is thought to stimulate the production of new collagen...

    journal_title:Lasers in surgery and medicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/lsm.1029

    authors: Goldberg DJ,Samady JA

    更新日期:2001-01-01 00:00:00

  • Water flux from partial-thickness skin wounds: comparative study of the effects of Er:YAG and Ho:YAG lasers.

    abstract:BACKGROUND AND OBJECTIVE:The clinical use of lasers to cut and coagulate tissue necessitates a better understanding of how the residual thermal damage affects healing. This study was designed to evaluate the effects of varying degrees of thermal damage on the healing process. STUDY DESIGN, MATERIALS AND METHODS:Partia...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9101(1996)18:1<1::AID-LSM1>3.0.

    authors: Jaffe BH,Walsh JT Jr

    更新日期:1996-01-01 00:00:00

  • Evaluation of the combined use of narrow band imaging and high-speed imaging to discriminate laryngeal lesions.

    abstract:BACKGROUND AND OBJECTIVE:Laryngeal lesions are usually investigated by microlaryngoscopy, biopsy, and histopathology. This study aimed to evaluate the combined use of Narrow Band Imaging (NBI) and High-Speed Imaging (HSI) in the differentiation of glottic lesions in awake patients. STUDY DESIGN:Prospective diagnostic ...

    journal_title:Lasers in surgery and medicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/lsm.22652

    authors: Volgger V,Felicio A,Lohscheller J,Englhard AS,Al-Muzaini H,Betz CS,Schuster ME

    更新日期:2017-08-01 00:00:00

  • Nanosecond pulse lasers for retinal applications.

    abstract:BACKGROUND AND OBJECTIVES:Thermal lasers are routinely used to treat certain retinal disorders although they cause collateral damage to photoreceptors. The current study evaluated a confined, non-conductive thermal, 3-nanosecond pulse laser in order to determine how to produce the greatest therapeutic range without cau...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.21087

    authors: Wood JP,Plunkett M,Previn V,Chidlow G,Casson RJ

    更新日期:2011-08-01 00:00:00

  • Argon laser iridotomy in primary angle-closure or pupillary block glaucoma.

    abstract::This paper describes the use of a pulsed argon laser to perform iridotomies in 87 patients. Diagnosis include: primary angle closure glaucoma, narrow angle in the fellow eye of patients with primary angle glaucoma, pupillary block, and after incomplete surgical iridectomies. Laser iridotomy was achieved in 79% of pati...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900010205

    authors: Schwartz LW,Spaeth GL

    更新日期:1980-01-01 00:00:00

  • Short-term microbiological effects of photodynamic therapy in non-surgical periodontal treatment of residual pockets: A split-mouth RCT.

    abstract:BACKGROUND AND OBJECTIVE:Photodynamic therapy (PDT) has been used as a therapeutic alternative to treat periodontitis, especially in challenging sites that require additional periodontal therapy such as residual pockets. The aim of this split-mouth randomized trial was to evaluate the microbiological and clinical effec...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/lsm.22449

    authors: Corrêa MG,Oliveira DH,Saraceni CH,Ribeiro FV,Pimentel SP,Cirano FR,Casarin RC

    更新日期:2016-12-01 00:00:00

  • Limitations of a thermal camera in measuring surface temperature of laser-irradiated tissues.

    abstract::Thermal cameras are used in research laboratories to measure tissue temperature during laser irradiation. This study was an evaluation of the accuracy of a 3-5 microns thermal camera and two 8-12 microns cameras in detecting the maximum temperatures of small targets. The size of the targets was within the range of las...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900100603

    authors: Torres JH,Springer TA,Welch AJ,Pearce JA

    更新日期:1990-01-01 00:00:00

  • A Comparison of Human and Porcine Skin in Laser-Assisted Drug Delivery of Chemotherapeutics.

    abstract:BACKGROUND AND OBJECTIVES:Porcine skin is a widely used model in diffusion studies, but its usefulness for laser-assisted drug delivery (LADD) has not been evaluated in comparison with human skin. This study compared porcine and human skin in ex vivo LADD diffusion studies. STUDY DESIGN/MATERIALS AND METHODS:Ex vivo a...

    journal_title:Lasers in surgery and medicine

    pub_type:

    doi:10.1002/lsm.23344

    authors: Rosenberg LK,Bagger C,Janfelt C,Haedersdal M,Olesen UH,Lerche CM

    更新日期:2020-11-08 00:00:00

  • Intravascular ultrasound can be used to evaluate pulsed laser ablation of arterial tissue.

    abstract:BACKGROUND AND OBJECTIVE:Intravascular ultrasound (IVUS) has been used successfully to detect intravascular lesions. This study evaluates the ability of IVUS to detect acoustic damage to the arterial wall following high power, pulsed laser ablation. STUDY DESIGN/MATERIALS AND METHODS:Arterial ablation and disruption w...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900160205

    authors: Friedl SE,Mathews ED,Miyamoto A,Abela GS

    更新日期:1995-01-01 00:00:00

  • Treatment of leg veins with combined pulsed dye and Nd:YAG lasers: 60 patients assessed at 6 months.

    abstract:INTRODUCTION:Leg telangiectasias have been reported to have been treated with a variety of lasers. This study was designed to measure response to treatment of leg telangiectasias with a unique coupled 585 nm and 1064 nm pulse. METHODS:Sixty female patients (24-62 y.o., skin types II-IV) with leg vein varicosities were...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.20972

    authors: Trelles MA,Weiss R,Moreno-Moragas J,Romero C,Vélez M,Alvarez X

    更新日期:2010-11-01 00:00:00

  • Comparison of a 1,550 nm Erbium: glass fractional laser and a chemical reconstruction of skin scars (CROSS) method in the treatment of acne scars: a simultaneous split-face trial.

    abstract:BACKGROUND AND OBJECTIVE:Acne scarring is a common complication of acne but no effective single treatment modality has been developed. To compare the efficacy of 1,550 nm Er:Glass fractional laser and chemical reconstruction of skin scar (CROSS) method in the treatment of acne scars. STUDY DESIGN/MATERIALS AND METHODS...

    journal_title:Lasers in surgery and medicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/lsm.20796

    authors: Kim HJ,Kim TG,Kwon YS,Park JM,Lee JH

    更新日期:2009-10-01 00:00:00

  • Laser assisted delivery of topical anesthesia for intramuscular needle insertion in adults.

    abstract:BACKGROUND AND OBJECTIVES:Currently there is no safe, effective, and rapid means to eliminate the pain associated with a needle insertion through the skin. It is hypothesized that ablation of the stratum corneum layer using a low energy Erbium(Er):YAG laser would allow rapid local anesthesia from a lidocaine product. ...

    journal_title:Lasers in surgery and medicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/lsm.10101

    authors: Shapiro H,Harris L,Hetzel FW,Bar-Or D

    更新日期:2002-01-01 00:00:00

  • Reduced in vivo local recurrence with contact neodymium: Yttrium-Aluminium-Garnet (Nd:YAG) laser scalpels.

    abstract:BACKGROUND AND OBJECTIVE:Local recurrence after surgical resection for breast cancer is a significant problem and is often not controlled by radiation or chemotherapy treatments. Local recurrence is thought to be, at least in part, due to residual disease, and/or due to the contamination of the surgical field during re...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900170406

    authors: Maker VK,Elseth KM,Radosevich JA

    更新日期:1995-01-01 00:00:00

  • Laser-activated solid protein bands for peripheral nerve repair: an vivo study.

    abstract:BACKGROUND AND OBJECTIVE:Severed tibial nerves in rats were repaired using a novel technique, utilizing a semiconductor diode-laser-activated protein solder applied longitudinally across the join. Welding was produced by selective laser denaturation of solid solder bands containing the dye indocyanine green. STUDY DES...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9101(1997)21:2<134::aid-lsm4>3.

    authors: Lauto A,Trickett R,Malik R,Dawes JM,Owen ER

    更新日期:1997-01-01 00:00:00

  • Induction of fat apoptosis by a non-thermal device: Mechanism of action of non-invasive high-intensity electromagnetic technology in a porcine model.

    abstract:OBJECTIVES:While controlled thermal changes in subcutaneous tissue have been used to trigger apoptosis of fat cells and have been proven clinically efficacious, another mechanism of electromagnetic stress suggests that fat apoptosis could be achieved by a non-thermal manner as well. This animal model study investigates...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.23039

    authors: Weiss RA,Bernardy J

    更新日期:2019-01-01 00:00:00

  • Collagen thermal damage and collagen synthesis after cutaneous laser resurfacing.

    abstract:BACKGROUND AND OBJECTIVE:Objectively measure and compare postoperative collagen thermal damage and subsequent new collagen synthesis after cutaneous laser resurfacing using two carbon dioxide laser systems. STUDY DESIGN/MATERIALS AND METHODS:We created 240 resurfacing wounds on eight piglets with scanned and short-pul...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9101(1998)23:2<66::aid-lsm3>3.0

    authors: Kuo T,Speyer MT,Ries WR,Reinisch L

    更新日期:1998-01-01 00:00:00

  • Comparison of 810 nm and 1064 nm wavelengths for interstitial laser photocoagulation in rabbit brain.

    abstract:BACKGROUND AND OBJECTIVE:This laboratory animal study is a comparison of Nd:YAG 1064 nm and diode 810 nm laser wavelengths in brain interstitial laser photocoagulation (ILP). Specific goals were to identify potential complications and physical characteristics of the thermal damage at both wavelengths prior to undertaki...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9101(1997)21:1<50::aid-lsm8>3.0

    authors: Wyman DR,Schatz SW,Maguire JA

    更新日期:1997-01-01 00:00:00

  • In vitro and in vivo tissue repair with laser-activated chitosan adhesive.

    abstract:BACKGROUND AND OBJECTIVES:Sutures are currently the gold standard for wound closure but they are still unable to seal tissue and may induce scarring or inflammation. Biocompatible glues, based on polysaccharides such as chitosan, are a possible alternative to conventional wound closure. In this study, the adhesion of l...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.20418

    authors: Lauto A,Stoodley M,Marcel H,Avolio A,Sarris M,McKenzie G,Sampson DD,Foster LJ

    更新日期:2007-01-01 00:00:00

  • New device for visual neodymium:YAG laser prostate ablation: acute and chronic canine evaluation.

    abstract::This canine study (n = 6) evaluated the acute and chronic effects of Nd:YAG laser prostatectomy using a Prolase II fiber. The Prolase II device consists of a 1,000 microns quartz fiber which directs a cone of Nd:YAG laser energy, at 45 degrees to the axis of the fiber, into the prostatic urethra under direct visual gu...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900150304

    authors: Kopchok GE,Back M,White RA,Cavaye DM,Peng SK,Moriel E,Rajfer J

    更新日期:1994-01-01 00:00:00

  • Spectroscopic, morphologic, and cytotoxic studies on major fractions of hematoporphyrin derivative and Photofrin II.

    abstract::This study characterizes the special properties of hematoporphyrin derivative (HpD) (Photofrin I) and Photofrin II with respect to the absorption and fluorescence spectra of the subfractions of the compounds in both solution and cells. In addition, data are presented demonstrating variation in the spectral amplitudes ...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900070207

    authors: Sun CH,Duzman E,Mellott J,Liaw LH,Berns MW

    更新日期:1987-01-01 00:00:00

  • Control of fibroblast populated collagen lattice contraction by antibody targeted photolysis of fibroblasts.

    abstract:BACKGROUND AND OBJECTIVE:Hypertrophic scarring and rigid scar contracture are disorders of wound healing for which there is presently no effective therapy. The dermal fibroblast plays a major role in scar fibrillogenesis and contracture. The objective of this study was to establish a selective and effective method to d...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9101(1997)21:3<235::aid-lsm3>3.

    authors: Strong LH,Berthiaume F,Yarmush ML

    更新日期:1997-01-01 00:00:00

  • Functional efficacy of glatiramer acetate treatment for laser-induced retinal damage in rats.

    abstract:BACKGROUND AND OBJECTIVES:To functionally evaluate the efficacy of glatiramer acetate (Cop-1) as a neuroprotective treatment for laser-induced retinal injuries in rats. STUDY DESIGN/MATERIALS AND METHODS:Using standard lasering and flash ERG techniques, we evaluated the effect of photocoagulation and of Cop-1 treatmen...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.20610

    authors: Belokopytov M,Ben-Shlomo G,Rosner M,Belkin M,Dubinski G,Epstein Y,Ofri R

    更新日期:2008-03-01 00:00:00

  • Nature: a rich source for developing multifunctional agents. Tumor-imaging and photodynamic therapy.

    abstract::The purpose of this review is to call attention in the use of chlorophyll-a and bacteriochlorophyll-a to develop more than 600 photosensitizers (lambda (max) 660 nm-800 nm) during the last 15 years (1990-2005) at the Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo. This article mainly includes the ...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章,评审

    doi:10.1002/lsm.20352

    authors: Pandey RK,Goswami LN,Chen Y,Gryshuk A,Missert JR,Oseroff A,Dougherty TJ

    更新日期:2006-06-01 00:00:00

  • Spot size reduction in coupling of laser to micromanipulator in laser microsurgery by fiberoptic link.

    abstract:BACKGROUND AND OBJECTIVE:In coupling laser with micromanipulator through fiberoptics, the resulting diameter of the spot is limited by the laws of geometrical optics, because of the high numerical aperture (N.A.) of fiberoptic radiation. A new method for the reduction of spot size diameter is suggested. STUDY DESIGN/M...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900170110

    authors: Logunov SL,Lemberg VG

    更新日期:1995-01-01 00:00:00

  • Possible hazards from irradiation with the carbon dioxide laser.

    abstract::Previous investigators, using relatively high irradiance levels, have been unable to demonstrate viable tissue in the plume during carbon dioxide laser vaporization. Our study was undertaken to reinvestigate this possibility, particularly at the lower irradiance levels that are currently in clinical use. Fresh post-mo...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.1900060117

    authors: Walker NP,Matthews J,Newsom SW

    更新日期:1986-01-01 00:00:00

  • Microwave thermolysis of sweat glands.

    abstract:BACKGROUND AND OBJECTIVES:Hyperhidrosis is a condition that affects a large percentage of the population and has a significant impact on peoples' lives. This report presents a technical overview of a new noninvasive, microwave-based device for creating thermolysis of sweat glands. The fundamental principles of operatio...

    journal_title:Lasers in surgery and medicine

    pub_type: 杂志文章

    doi:10.1002/lsm.21142

    authors: Johnson JE,O'Shaughnessy KF,Kim S

    更新日期:2012-01-01 00:00:00