Abstract：
BACKGROUND AND OBJECTIVE:Local recurrence after surgical resection for breast cancer is a significant problem and is often not controlled by radiation or chemotherapy treatments. Local recurrence is thought to be, at least in part, due to residual disease, and/or due to the contamination of the surgical field during resection. STUDY DESIGN MATERIALS AND METHODS: To address this later concern, we defined a model system using the mouse mammary cell line, EMT6. Using this model system, we have directly compared the rate of local recurrence of two different surgical approaches. One approach employed the use of traditional surgical instruments, and the other used a comparatively new contact Nd:YAG laser system. Tumor-bearing animals (242) were randomized into three groups. One group consisted of 50 animals that were not treated; 103 animals were randomized into a treatment group that received surgical resection using traditional instruments; 89 animals were resected using the contact laser system. In both surgical procedures, an intentional incision was made through the tumor and then through an uninvolved portion of the surgical field in an attempt to "seed" the incision using the contaminated surgical instrument. RESULTS:Twenty-one of the 103 scalpel-treated animals had local recurrence; only seven of the 89 laser-treated animal had local recurrence. The untreated group died of disease within 8 weeks. In the treatment groups, recurrences were palpable within 1 week. At the time of death for all groups, no metastatic lesions were noted. CONCLUSION:These findings support the conclusions that the EMT6 cell line is a useful model to study local recurrence and that contact laser surgery provides about a 50% improvement in the control of local disease in vivo (P < 0.05).
journal_name
Lasers Surg Medjournal_title
Lasers in surgery and medicineauthors
Maker VK,Elseth KM,Radosevich JAdoi
10.1002/lsm.1900170406subject
Has Abstractpub_date
1995-01-01 00:00:00pages
370-4issue
4eissn
0196-8092issn
1096-9101journal_volume
17pub_type
杂志文章abstract：:This investigation was designed to compare standard scalpel transections of the tibial branch of the rat sciatic nerve with those performed using either a milliwatt carbon dioxide (CO2) or a potassium titanyl phosphate (KTP/532) laser. Four transection groups consisted of nerves sectioned with (1) scalpel (control), (...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900120109
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:In the last decade, many different kinds of therapies have emerged as a consequence of advances in the field of applied technology. It is known that low level laser therapy contributes to tissue healing; however, the use of photodynamic therapy (PDT) in healing and the scar formation processes...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.20062
更新日期：2004-01-01 00:00:00
abstract：:During a ten-year period 642 abdominal hollow organ resections have been performed by means of a new, original technique--that is, CO2 laser irradiation combined with specially designed instrumentation. This resulted in a remarkable decrease in postoperative morbidity and mortality. The article describes the laser pro...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900070402
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Variable square pulse (VSP) Er:YAG laser should be quicker than older Er:YAG lasers. The objectives were: (1) comparison of VSP laser and mechanical handpiece efficacy for apicectomy and (2) determination of optimal pulse width/energy/frequency combination. STUDY DESIGN/MATERIALS AND METHODS:...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.20168
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:The treatment of acne scars with fractional CO(2) lasers is gaining increasing impact, but has so far not been compared side-by-side to untreated control skin. OBJECTIVE:In a randomized controlled study to examine efficacy and adverse effects of fractional CO(2) laser resurfacing for atrophic acne scars com...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章,随机对照试验
doi：10.1002/lsm.22048
更新日期：2012-08-01 00:00:00
abstract：INTRODUCTION:Photodynamic therapy is a proven therapeutic modality in the management of variety of pathologies involving the human body. Our aim in this clinical study is to prospectively evaluate the outcome following interstitial photodynamic therapy for patients with vascular anomalies. Patients' reports on quality ...
journal_title：Lasers in surgery and medicine
pub_type： 临床试验,杂志文章
doi：10.1002/lsm.21058
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Short pulsed and scanned CO(2) lasers that target water molecules are currently used for cutaneous resurfacing. These CO(2) resurfacing lasers produce acute cutaneous contraction, which can be quantitated as a measure of the laser's effect. We postulated that targeting the vibrational and rotat...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/(sici)1096-9101(1999)25:1<1::aid-lsm1>3.0.
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Holmium laser lithotripsy is the gold standard for intracorporeal fragmentation of urinary calculi. Usually, a visible beam is superimposed on the IR treatment laser as an aiming beam to guide the surgeon. In vitro tests showed that this aiming beam (532 nm, power <1 mW) excites strong fluores...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.22611
更新日期：2017-04-01 00:00:00
abstract：:This is the first report on the use of endoscopic argon photoirradiation to treat patients with low-grade ureteral tumors involving the distal ureter. Using a rigid ureteropyeloscope, a 300 mu or 600 mu quartz fiber, and 5 watts (W) of power in a continuous-wave mode, the lesions were ablated without complication. Pat...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900120506
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Kenalog application onto surgical wounds has been used to control dynamic pain following Laser-Assisted-Uvulo-Palatoplasty (LAUP) with good results in our department. When the effect was sub-optimal, insufficient ointment over the superior-lateral corner of wounds were always noted. Fulfilling...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.21122
更新日期：2011-11-01 00:00:00
abstract：:A synthetic contact sapphire endoprobe attached to the quartz fiber of a neodymium:yttrium aluminum garnet (Nd:YAG) laser had been used in the transurethral treatment of bladder tumors. A total of 68 operations have been carried out in 48 patients. The contact probe was placed directly into the tumor under direct visi...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900070616
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Optical microangiography (OMAG) is a noninvasive technique capable of imaging 3D microvasculature. OMAG-based optical lymphangiography has been developed for 3D visualization of lymphatic vessels without the need for exogenous contrast agents. In this study, we utilize the optical lymphangiogr...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.22387
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Er:YAG laser has been used for caries removal and cavity preparation, using ablative parameters. Its effect on the margins of restorations submitted to cariogenic challenge has not yet been sufficiently investigated. The aim of this study was to assess the enamel adjacent to restored Er:YAG la...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章,随机对照试验
doi：10.1002/lsm.20684
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVES:Photodynamic therapy (PDT) is an effective cancer treatment that uses photosensitizers, light, and oxygen to destroy malignant cells. Porphyrins, and in particular the cationic derivatives, are the most investigated photosensitizers for PDT. In this context, it is important to study new methodologies to deve...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.22824
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Alternative treatments are needed to achieve consistent and more complete port wine stain (PWS) removal, especially in darker skin types; photodynamic therapy (PDT) is a promising alternative treatment. To this end, we previously reported on Talaporfin Sodium (TS)-mediated PDT. It is essential ...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.22677
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:A novel, noninvasive technology, utilizing suction-coupled radiofrequency (RF) heating and ultra-short pulse duration, high-voltage electrical pulses was studied for its efficacy and safety on adipose tissue reduction. METHODS:Twenty-one subjects underwent treatment of their abdominal fat once...
journal_title：Lasers in surgery and medicine
pub_type： 临床试验,杂志文章
doi：10.1002/lsm.22223
更新日期：2014-02-01 00:00:00
abstract：UNLABELLED:BACKGROUND AND OBJECTIVE To examine the biophysical effects of photothermal heating on herniated intervertebral discs during laser decompression surgery. STUDY DESIGN/MATERIALS AND METHODS:Ex vivo bovine nucleus pulposus specimens were irradiated with a Nd: YAG laser (lambda = 1.32 microm, 100 seconds expos...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1046
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Previously, we have shown that a 43°C pretreatment can provide thermotolerance to a following, more severe, thermal stress at 45°C. Using cells that lack the Hsp70 gene, we have also shown that there is still some thermotolerance in the absence of HSP70 protein. The purpose of this study was t...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.20983
更新日期：2010-12-01 00:00:00
abstract：:Low power laser irradiation has been reported to cause biological effects due to the photochemical and/or photophysical action of the radiation. This study determined quantitatively if transcutaneous low power laser irradiation can affect the regeneration of the rat facial nerve. The facial nerve was crushed unilatera...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900130113
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Intralipid (IP) is a scatterer extensively used in the building of phantoms for Biomedical Optics measurements. Recently, deviations from the linearity have been shown for the concentration scaling law of the scattering coefficient of IP water solutions at visible wavelengths. In this work thi...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.20157
更新日期：2005-06-01 00:00:00
abstract：:partial ciliary processes argon laser photocoagulation (PCLP) in the management of glaucoma has been the subject of a carefully conducted, prospective 5+-year clinical trial in 22 eyes of 20 patients. The mean intraocular pressure (IOP) +/- SD was significantly lower (15.5 +/- 3.6 mm Hg) than before the procedure (29....
journal_title：Lasers in surgery and medicine
pub_type： 临床试验,杂志文章
doi：10.1002/lsm.1900010109
更新日期：1980-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Chlorophyllin-M is a new chlorophyll-based derivative photosensitive compound developed by our research group with easy laboratorial synthesis and ideal properties for photodynamic therapy (PDT). It is intended for clinical treatments with simple and low cost techniques and reagents. The object...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.22362
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:We present a new theory of selective thermal damage of non-uniformly pigmented structures in biological tissues. Spatial separation of the heavily pigmented areas and the target requires limitation of the pigment temperature and heat diffusion from the pigmented to the targeted areas. STUDY DE...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1136
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:To determine whether laser light can improve healing of skin wounds by killing wound bacteria while simultaneously accelerating host tissue activity. MATERIALS AND METHODS:Wounds on the rat dorsum were irradiated or sham-irradiated three times weekly from days 1 to 19 using 635 or 808 nm diode lasers at 1 or...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.20769
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:To produce controlled, spatially confined thermal effects in dermis. STUDY DESIGNS/MATERIALS AND METHODS:A 1 W, 1,500 nm fiber-coupled diode laser was focused with a high numerical aperture (NA) objective to achieve a tight optical focus within the upper dermis of skin held in contact with a ...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.20142
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The clinical use of lasers to cut and coagulate tissue necessitates a better understanding of how the residual thermal damage affects healing. This study was designed to evaluate the effects of varying degrees of thermal damage on the healing process. STUDY DESIGN, MATERIALS AND METHODS:Partia...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/(SICI)1096-9101(1996)18:1<1::AID-LSM1>3.0.
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Laser-induced photo thermal damage has been combined with photodynamic therapy (PDT) using a systemic photosensitiser to treat vascular lesions. The efficacy of PDT using systemic 5-aminolaevulinic acid (5-ALA) as the photosensitiser and pulsed dye laser (PDL) as the light source in port wine ...
journal_title：Lasers in surgery and medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1002/lsm.20151
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Pores in the sclera are a candidate pathway for aqueous transport and therefore can be utilized to decrease the intraocular pressure (IOP) in glaucomatous eyes. Since pore formation is a well-known mechanism for stress relaxation in solids, laser-induced creation of pores in cartilage increase...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.22202
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To evaluate the effects on disruption of hair growth of the non-coherent filtered flashlamp intense pulsed light (IPL) source. MATERIALS AND METHODS:Twenty-eight sites on 23 patients with Fitzpatrick type I-III were enrolled using a single treatment IPL followed for three months post-treatment...
journal_title：Lasers in surgery and medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1002/(sici)1096-9101(1999)24:2<128::aid-lsm8>3.
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Helicobacter pylori (HP) is an endemic pathogenic bacterium causing gastritis and gastroduodenal ulceration in humans and is linked to the development of gastric malignancies. These first human in vivo studies investigated the photoeradication of HP using laser and white light. STUDY DESIGN/M...
journal_title：Lasers in surgery and medicine
pub_type： 临床试验,杂志文章
doi：10.1002/lsm.10066
更新日期：2002-01-01 00:00:00
