Abstract:
BACKGROUND AND OBJECTIVES:Laser-induced photo thermal damage has been combined with photodynamic therapy (PDT) using a systemic photosensitiser to treat vascular lesions. The efficacy of PDT using systemic 5-aminolaevulinic acid (5-ALA) as the photosensitiser and pulsed dye laser (PDL) as the light source in port wine stains (PWS) is unknown. STUDY DESIGNS/MATERIALS AND METHODS:We conducted an internally controlled pilot study comparing the efficacy of PDT using PDL as a light source, to PDL alone in the treatment of PWS. RESULTS:The PWS improved slightly in all patients but no significant difference was found between the three treatment arms in terms of lesional lightening or incidence and severity of side effects. CONCLUSIONS:There was no evidence of increased efficacy of PDT using PDL as a light source compared to PDL alone. There was also no significant difference in adverse events. Further studies using different treatment regimens over longer periods of time may be warranted.
journal_name
Lasers Surg Medjournal_title
Lasers in surgery and medicineauthors
Evans AV,Robson A,Barlow RJ,Kurwa HAdoi
10.1002/lsm.20151subject
Has Abstractpub_date
2005-04-01 00:00:00pages
266-9issue
4eissn
0196-8092issn
1096-9101journal_volume
36pub_type
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