Abstract:
BACKGROUND AND OBJECTIVES:Many studies have investigated the application of micro-insulated needles with radio frequency (RF) to treat acne in humans; however, the use of a micro-insulated needle RF applicator has not yet been studied in an animal model. The purpose of this study was to evaluate the effectiveness of a micro-insulated needle RF applicator in a rabbit ear acne (REA) model. STUDY DESIGN/MATERIALS AND METHODS:In this study, we investigated the effect of selectively destroying the sebaceous glands using a micro-insulated needle RF applicator on the formation of comedones induced by application of 50% oleic acid and intradermal injection of P. acnes in the orifices of the external auditory canals of rabbits. The effects of the micro-insulated needle RF applicator treatment were evaluated using regular digital photography in addition to 3D Primos imaging evaluation, Skin Visio Meter microscopic photography, and histologic analyses. RESULTS:Use of the micro-insulated needle RF applicator resulted in successful selective destruction of the sebaceous glands and attenuated TNF-alpha release in an REA model. The mechanisms by which micro-insulated needles with RF using 1 MHz exerts its effects may involve inhibition of comedone formation, triggering of the wound healing process, and destruction of the sebaceous glands and papules. CONCLUSION:The use of micro-insulated needles with RF applicators provides a safe and effective method for improving the appearance of symptoms in an REA model. The current in vivo study confirms that the micro-insulated needle RF applicator is selectively destroying the sebaceous glands. Lasers Surg. Med. 49:395-401, 2017. © 2016 Wiley Periodicals, Inc.
journal_name
Lasers Surg Medjournal_title
Lasers in surgery and medicineauthors
Kwon TR,Choi EJ,Oh CT,Bak DH,Im SI,Ko EJ,Hong HK,Choi YS,Seok J,Choi SY,Ahn GY,Kim BJdoi
10.1002/lsm.22599subject
Has Abstractpub_date
2017-04-01 00:00:00pages
395-401issue
4eissn
0196-8092issn
1096-9101journal_volume
49pub_type
杂志文章abstract:BACKGROUND AND OBJECTIVES:Hypervascular skin lesions (HVSL) are treated with medical lasers characterized by a variety of parameters such as wavelength lambda, pulse duration t(p), and radiant exposure E that can be adjusted for different pathology and blood vessel size. Treatment parameters have been optimized assumin...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.20154
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Soft tissue sarcomas (STS) are a rare and heterogeneous group of malignant tumors that are often treated through surgical resection. Current intraoperative margin assessment methods are limited and highlight the need for an improved approach with respect to time and specificity. Here we investi...
journal_title:Lasers in surgery and medicine
pub_type: 临床试验,杂志文章
doi:10.1002/lsm.22564
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The metabolic flexibility is often impaired in diseases associated with obesity, and many studies are based on the hypothesis that dysfunction in peripheral tissues such as skeletal muscle, liver and adipose tissue represent the etiology of development of metabolic inflexibility. Experimental e...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章,随机对照试验
doi:10.1002/lsm.22395
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:5-Aminolevulinic acid based photodynamic therapy (5-ALA-PDT) has revealed promising results in the treatment of inflammatory joint diseases due to the sensitivity of inflamed synovial tissue. For 5-ALA-PDT to be safe and beneficial for intra-articular applications, resistance of chondrocytes is essential to p...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.20625
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Kenalog application onto surgical wounds has been used to control dynamic pain following Laser-Assisted-Uvulo-Palatoplasty (LAUP) with good results in our department. When the effect was sub-optimal, insufficient ointment over the superior-lateral corner of wounds were always noted. Fulfilling...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.21122
更新日期:2011-11-01 00:00:00
abstract::Thermal cameras are used in research laboratories to measure tissue temperature during laser irradiation. This study was an evaluation of the accuracy of a 3-5 microns thermal camera and two 8-12 microns cameras in detecting the maximum temperatures of small targets. The size of the targets was within the range of las...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.1900100603
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:This work evaluates the application of a 810 nm diode laser operating in the range of 400-1,200 mW for bacterial reduction at periodontal treatment. The aim of this study is to examine the immediate effect of the diode medium power laser in reducing the bacterial concentration at periodontal po...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.20039
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The main factors in photodynamic therapy (PDT) are: photosensitizer retention, photon absorption, and oxygen supply. Each factor has its unique set of problems that poses limitation to the treatment. Both light delivery and oxygen supply are significant bottlenecks in PDT. Vascular closure duri...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.20951
更新日期:2010-09-01 00:00:00
abstract:INTRODUCTION:Leg telangiectasias have been reported to have been treated with a variety of lasers. This study was designed to measure response to treatment of leg telangiectasias with a unique coupled 585 nm and 1064 nm pulse. METHODS:Sixty female patients (24-62 y.o., skin types II-IV) with leg vein varicosities were...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.20972
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVES:Photodynamic therapy (PDT) is an effective cancer treatment that uses photosensitizers, light, and oxygen to destroy malignant cells. Porphyrins, and in particular the cationic derivatives, are the most investigated photosensitizers for PDT. In this context, it is important to study new methodologies to deve...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.22824
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:Our skin is constantly exposed to light from solar radiation and electronic devices, which impact skin physiology and aging. The biological altering properties of ultraviolet (UV) solar radiation on skin have been well established. There is significant scientific and public interest on the effects of electro...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.22794
更新日期:2018-02-05 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Facial teleangectasias can be a relevant cosmetic problem, which the patient usually hides with a thick layer of makeup. This study will describe the response on these vascular lesions using the intense pulsed light (IPL) source. METHODS:Five hundred eighteen consecutive patients were treated...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.20187
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Laser has been reported as a heat source for melting and re-crystallization. Occurring at about 1100 degrees C, the melting of surface dental enamel along with re-crystallization might have an assistant role in the therapy of hypersensitive tooth, apical sealing of endodontic surgery in dentis...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.10124
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To produce controlled, spatially confined thermal effects in dermis. STUDY DESIGNS/MATERIALS AND METHODS:A 1 W, 1,500 nm fiber-coupled diode laser was focused with a high numerical aperture (NA) objective to achieve a tight optical focus within the upper dermis of skin held in contact with a ...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.20142
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Optical energy-based devices, including intense pulsed light (IPL) and potassium titanyl phosphate (KTP) lasers achieve reduction of pigmented and vascular lesions in a relatively similar number of treatments. This study aimed to evaluate the efficacy and safety of an IPL with a "KTP-like" filter emitting a ...
journal_title:Lasers in surgery and medicine
pub_type: 临床试验,杂志文章
doi:10.1002/lsm.23056
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:Inflammation is a well-known consequence of surgery. Although surgical debulking of tumor is beneficial to patients, the onset of inflammation in injured tissue may impede the success of adjuvant therapies. One marker for postoperative inflammation is IL-6, which is released as a consequence of surgical injur...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章,随机对照试验
doi:10.1002/lsm.22934
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The goal of this study was to use an inexpensive macroscopic imaging system to monitor tumor progression in mouse models in real-time with minimal intervention. STUDY DESIGN/MATERIALS AND METHODS:Illumination is provided via a xenon arc lamp and a fiber optic probe which delivers white light o...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.20409
更新日期:2006-12-01 00:00:00
abstract::This study characterizes the special properties of hematoporphyrin derivative (HpD) (Photofrin I) and Photofrin II with respect to the absorption and fluorescence spectra of the subfractions of the compounds in both solution and cells. In addition, data are presented demonstrating variation in the spectral amplitudes ...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.1900070207
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:This study was conducted to clarify the morphologic characteristics and subsequent repair process of coagulation necrosis produced by pulsed CO(2) laser irradiation with relatively low fluence, and thereby to evaluate the clinical efficacy of this irradiation mode. STUDY DESIGN/MATERIALS AND ...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.20712
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Riehl's melanosis is a chronic acquired hyperpigmentation disorder that causes significant cosmetic problems for patients with this condition. Several treatment options, including low-fluence Q-switched Nd:YAG (QSNY) 1064-nm laser treatment, have been attempted with inconsistent results. We ai...
journal_title:Lasers in surgery and medicine
pub_type:
doi:10.1002/lsm.23214
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Reflectance confocal microscopy (RCM) is a developing approach for noninvasive detection of oral lesions with label-free contrast and cellular-level resolution. For access into the oral cavity, confocal microscopes are being configured with small-diameter telescopic probes and small objective lenses. However...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.23090
更新日期:2019-05-08 00:00:00
abstract:BACKGROUND:Photodynamic therapy (PDT) offers the potential for enhanced treatment of nonmelanoma skin cancer (NMSC) with minimal scarring. Yet, PDT has not achieved consistent long term effectiveness to gain widespread clinical acceptance for treatment of skin cancer. Therapeutic response varies between practitioners, ...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.22139
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The difficulties typically encountered in studying the effects of restorations on tooth reinforcement are often due to the 3-dimensional (3D) nature of deformation. Therefore, electronic 3D-Speckle-Interferometry (3D-ESPI) was used to assess the impact of different restorative materials on the...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.20036
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The purpose of this study was to compare the effect of Low-Level Laser Therapy (LLLT) with sham and whirlpool treatment on the contracted knee joint in rat. STUDY DESIGN/MATERIALS AND METHODS:Forty-eight Wistar rats were operated on to immobilize knee joint, and 1 week after operation they wer...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/(sici)1096-9101(1998)22:2<81::aid-lsm3>3.0
更新日期:1998-01-01 00:00:00
abstract::The fourth harmonic wavelength (266 nm) of a neodymium YAG laser was used to cut precise grooves on the surface of the human cornea. Well-controlled cuts were made using the laser operating at 1.3 kHz. The width of the grooves was 2-3 micron. The depth could be controlled by varying the amount of laser exposure. ...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.1900050405
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:To investigate the morphology of cementum and root dentin after Er:YAG laser irradiation with and without water coolant, compared to that after CO(2) laser irradiation and an untreated surface. STUDY DESIGN/MATERIALS AND METHODS:Ten extracted healthy human teeth were used. Er:YAG and CO(2) la...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.10074
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To further understand the precise process of the tumor cell degeneration after photodynamic therapy (PDT), laser hyperthermic therapy (LH), and combined treatments using an Nd:YAG laser. It is important to examine initial morphological alteration of tumor cells after these treatments. STUDY DE...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.1900160308
更新日期:1995-01-01 00:00:00
abstract::A laser endoscope was devised using optic fibers in order to provide a means of visualization and removal of atheromatous plaques from arteries in cadavers and experimental animals. Atheromatous plaques were satisfactorily lased off in a few seconds, although contraction of lased vessels was observed. A self-focusing ...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.1900040408
更新日期:1984-01-01 00:00:00
abstract::Laser-induced fluorescence may be used to guide laser ablation of atherosclerotic lesions. This study was performed to evaluate arterial autofluorescence spectroscopy in vitro using a single XeCl excimer laser (308 nm) for simultaneous tissue ablation and fluorescence excitation. The laser beam was coupled to a 600-mi...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.1900140306
更新日期:1994-01-01 00:00:00
abstract::Low power laser irradiation has been reported to cause biological effects due to the photochemical and/or photophysical action of the radiation. This study determined quantitatively if transcutaneous low power laser irradiation can affect the regeneration of the rat facial nerve. The facial nerve was crushed unilatera...
journal_title:Lasers in surgery and medicine
pub_type: 杂志文章
doi:10.1002/lsm.1900130113
更新日期:1993-01-01 00:00:00