Abstract:
BACKGROUND AND OBJECTIVES:Hypervascular skin lesions (HVSL) are treated with medical lasers characterized by a variety of parameters such as wavelength lambda, pulse duration t(p), and radiant exposure E that can be adjusted for different pathology and blood vessel size. Treatment parameters have been optimized assuming constant optical properties of blood during laser photocoagulation. However, recent studies suggest that this assumption may not always be true. Our objective was to quantify thermally induced changes in blood that occur during irradiation using standard laser parameters. STUDY DESIGN/MATERIALS AND METHODS:Glass capillary tubes (diameter D = 100, 200, and 337 microm) filled with fresh or hemolyzed rabbit blood were irradiated once at lambda = 585, 595, or 600 nm, t(p) = 1.5 milliseconds; and also at lambda = 585 nm, t(p) = 0.45 milliseconds. E was increased until blood ablation caused formation of permanent gas bubbles. In a corroborative study, human blood was heated at 50 degrees C and absorbance spectra were measured as a function of time. RESULTS:Threshold radiant exposure, E(thresh), for gas bubble formation was found not to depend on lambda, which might be surprising in view of the 10-fold lower absorption coefficient at 600 nm as compared to 585 nm. The spectroscopic study revealed heat-induced changes in blood constituent composition of hemoglobins (Hb) from initially 100% oxyhemoglobin (HbO2) to deoxyhemoglobin (HHb) and, ultimately, methemoglobin (metHb) as the major constituent. Model calculations of E(thresh)(lambda,D) based on changing constituent blood composition during heating with milliseconds lasers were found to correlate with experimental results. CONCLUSIONS:For laser treatment of HVSL it appears that lambda is of secondary importance and that the choice of t(p) is a more important factor.
journal_name
Lasers Surg Medjournal_title
Lasers in surgery and medicineauthors
Kimel S,Choi B,Svaasand LO,Lotfi J,Viator JA,Nelson JSdoi
10.1002/lsm.20154subject
Has Abstractpub_date
2005-04-01 00:00:00pages
281-8issue
4eissn
0196-8092issn
1096-9101journal_volume
36pub_type
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journal_title:Lasers in surgery and medicine
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journal_title:Lasers in surgery and medicine
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journal_title:Lasers in surgery and medicine
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journal_title:Lasers in surgery and medicine
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journal_title:Lasers in surgery and medicine
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journal_title:Lasers in surgery and medicine
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journal_title:Lasers in surgery and medicine
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journal_title:Lasers in surgery and medicine
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journal_title:Lasers in surgery and medicine
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journal_title:Lasers in surgery and medicine
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journal_title:Lasers in surgery and medicine
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更新日期:2002-01-01 00:00:00
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journal_title:Lasers in surgery and medicine
pub_type: 杂志文章,随机对照试验
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abstract:BACKGROUND AND OBJECTIVE:Despite the successful application of laser in animal experiments and clinics, the adjustment of laser parameters during surgery is still unclear. This study aimed to investigate the effect of different 980-nm diode laser parameters in hepatectomy. This could provide a clear protocol for using ...
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journal_title:Lasers in surgery and medicine
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journal_title:Lasers in surgery and medicine
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abstract:BACKGROUND AND OBJECTIVES:To determine the true efficacy of the 308-nm excimer laser for the treatment of vitiligo, while taking into account confounding factors such as anatomic site of treatment, age, sex, skin type, MED, and duration of evolution of the vitiligo. STUDY DESIGN/MATERIALS AND METHODS:Thirty-five patie...
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pub_type: 杂志文章,随机对照试验
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journal_title:Lasers in surgery and medicine
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