Water flux from partial-thickness skin wounds: comparative study of the effects of Er:YAG and Ho:YAG lasers.

Abstract:

BACKGROUND AND OBJECTIVE:The clinical use of lasers to cut and coagulate tissue necessitates a better understanding of how the residual thermal damage affects healing. This study was designed to evaluate the effects of varying degrees of thermal damage on the healing process. STUDY DESIGN, MATERIALS AND METHODS:Partial-thickness lesions were created in guinea pig skin using an Er:YAG laser, a Ho:YAG laser, and a scalpel. To monitor recovery of the stratum corneum, water flux from the wound sites was quantified and histological data obtained for approximately one week. RESULTS:The data indicate an exponential water loss pattern from all wounds. Water flux from the scalpel- and the Er:YAG laser-induced wounds was initially high but decreased rapidly with decay rates (mean +/- SE) of 0.46 +/- 0.01 day-1 and 0.38 +/- 0.01 day-1, respectively. The Ho:YAG laser-induced wounds demonstrated a different pattern of decay with lower water flux values initially and a decay rate of only 0.13 +/- 0.01 day-1. CONCLUSION:Histological and water flux data reveal that Er:YAG laser-induced wounds achieve epidermal integrity only slightly after scalpel-induced lesions, and Ho:YAG laser-induced wounds heal substantially slower and contain more granulation tissue.

journal_name

Lasers Surg Med

authors

Jaffe BH,Walsh JT Jr

doi

10.1002/(SICI)1096-9101(1996)18:1<1::AID-LSM1>3.0.

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

1-9

issue

1

eissn

0196-8092

issn

1096-9101

pii

10.1002/(SICI)1096-9101(1996)18:1<1::AID-LSM1>3.0.

journal_volume

18

pub_type

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