Extended theory of selective photothermolysis.

Abstract:

BACKGROUND AND OBJECTIVE:We present a new theory of selective thermal damage of non-uniformly pigmented structures in biological tissues. Spatial separation of the heavily pigmented areas and the target requires limitation of the pigment temperature and heat diffusion from the pigmented to the targeted areas. STUDY DESIGNS/MATERIALS AND METHODS:A concept of selective target damage by heat diffusion is presented for three target geometries: planar, cylindrical, and spherical. An in vitro experiment is described in which the dependence of thermal damage on pulsewidth at constant fluence was evaluated. RESULTS:The in vitro experiment showed that the size of the damage zone for similar hair follicles was pulsewidth-independent over a very broad range of pulsewidths (30-400 ms). We formulated a new theory (extended theory of photothermolysis) to interpret the experimental results. CONCLUSIONS:Based on this new theory, the treatment pulsewidth for non-uniformly pigmented targets is significantly longer than the target thermal relaxation time (TRT). The theory provides new recommendations for photoepilation and photosclerotherapy parameters.

journal_name

Lasers Surg Med

authors

Altshuler GB,Anderson RR,Manstein D,Zenzie HH,Smirnov MZ

doi

10.1002/lsm.1136

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

416-32

issue

5

eissn

0196-8092

issn

1096-9101

pii

10.1002/lsm.1136

journal_volume

29

pub_type

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