Collagen thermal damage and collagen synthesis after cutaneous laser resurfacing.

Abstract:

BACKGROUND AND OBJECTIVE:Objectively measure and compare postoperative collagen thermal damage and subsequent new collagen synthesis after cutaneous laser resurfacing using two carbon dioxide laser systems. STUDY DESIGN/MATERIALS AND METHODS:We created 240 resurfacing wounds on eight piglets with scanned and short-pulsed lasers using the manufacturer's suggested settings. The wounds varied with respect to the number of laser passes and postoperative survival times. Samples were harvested for histological analysis. RESULTS:The scanned laser resulted in an average of 52% more collagen thermal damage on the day of surgery (P < 0.0001) and an average of 78% more thermal damage 3 days postoperative (P < 0.0001) than the short-pulsed laser. The amount of new collagen synthesis correlated with the amount of thermal damage, with the scanned laser wounds showing 44% greater new collagen synthesis than the short-pulsed laser wounds on postoperative day 7 (P < 0.0001) and 48% greater new collagen synthesis on postoperative day 14 (P < 0.0001). CONCLUSION:Compared to the short-pulsed laser, the scanned laser results in a greater depth of collagen thermal damage with a correspondingly greater depth of new collagen synthesis after cutaneous resurfacing.

journal_name

Lasers Surg Med

authors

Kuo T,Speyer MT,Ries WR,Reinisch L

doi

10.1002/(sici)1096-9101(1998)23:2<66::aid-lsm3>3.0

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

66-71

issue

2

eissn

0196-8092

issn

1096-9101

pii

10.1002/(SICI)1096-9101(1998)23:2<66::AID-LSM3>3.0

journal_volume

23

pub_type

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