CO2 laser-resurfacing: increased risk of side effects after uv-exposure-an experimental animal study.

Abstract:

BACKGROUND AND OBJECTIVES:Carbon dioxide (CO(2)) laser resurfacing is primarily performed on photodamaged facial skin where patients are further exposed to ultraviolet radiation (UVR) postoperatively. We examined whether pre- and postoperative UVR influences the development of CO(2) laser-induced side effects. STUDY DESIGN/MATERIALS AND METHODS:Hairless mice (n = 211) were treated with a Sharplan CO(2) laser with FeatherTouch scanner. Simulated solar irradiation was administered either preoperatively or pre- and postoperatively. Skin end-points (wounds, texture changes, and pigmentary changes) were evaluated blinded by clinical evaluations, skin reflectance spectroscopy, and histological examinations. RESULTS:Pre- and postoperative UVR exposed mice obtained higher clinical scores of wounds (P < 0.02) and texture changes (P < 0.01) and developed more heavy fibrosis than mice treated with laser but no UVR. UVR exposure after CO(2) laser treatment induced significant hyperpigmentation compared to unexposed control mice (P < 0.003), whereas CO(2) laser treatment itself did not induce pigmentary changes. CONCLUSIONS:UVR increases in an animal model the occurrence of postoperative side effects from CO(2) laser resurfacing.

journal_name

Lasers Surg Med

authors

Hedelund L,Haedersdal M,Egekvist H,Heidenheim M,Hans CW,Poulsen T

doi

10.1002/lsm.20135

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

79-84

issue

2

eissn

0196-8092

issn

1096-9101

journal_volume

36

pub_type

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