Abstract：
BACKGROUND AND OBJECTIVES:Sutures are currently the gold standard for wound closure but they are still unable to seal tissue and may induce scarring or inflammation. Biocompatible glues, based on polysaccharides such as chitosan, are a possible alternative to conventional wound closure. In this study, the adhesion of laser-activated chitosan films is investigated in vitro and in vivo. In particular we examine the effect of varying the laser power, as well as adding a natural cross-linker (genipin) to the adhesive composition. STUDY DESIGN/MATERIALS AND METHODS:Flexible and insoluble strips of chitosan films (surface area approximately 34 mm(2), thickness approximately 20 microm) were bonded to sheep intestine using several laser powers (0, 80, 120, and 160 mW) at 808-nm wavelength. The strength of repaired tissue was tested by a calibrated tensiometer to select the best power. A natural cross-linker (genipin) was also added to the film and the tissue repair strength compared with the strength of plain films. The adhesive was also bonded in vivo to the sciatic nerve of rats and the thermal damage induced by the laser assessed 4 days post-operatively. RESULTS:Chitosan adhesives successfully repaired intestine tissue, attaining a maximum repair strength of 14.7+/-4.3 kPa (n = 30) at the laser power of 120 mW. The chitosan-genipin films achieved lower repair strength (9.1+/-2.9 kPa). The laser caused partial demyelination of axons at the site of operation, but the myelinated axons retained a normal morphology proximally and distally. CONCLUSIONS:The chitosan adhesive effectively bonded to tissue causing only localized thermal damage in vivo, when the appropriate laser parameters were selected.
journal_name
Lasers Surg Medjournal_title
Lasers in surgery and medicineauthors
Lauto A,Stoodley M,Marcel H,Avolio A,Sarris M,McKenzie G,Sampson DD,Foster LJdoi
10.1002/lsm.20418subject
Has Abstractpub_date
2007-01-01 00:00:00pages
19-27issue
1eissn
0196-8092issn
1096-9101journal_volume
39pub_type
杂志文章abstract：BACKGROUND AND OBJECTIVE:Interstitial photodynamic therapy (iPDT) of non-resectable recurrent glioblastoma using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) has shown a promising outcome. It remained unclear, however, to what extent inter- and intra-tumoural differences of PpIX concentrations influence...
journal_title：Lasers in surgery and medicine
pub_type： 临床试验,杂志文章
doi：10.1002/lsm.22126
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To evaluate safety and efficacy of treatment with the picosecond Nd:YAG 532 nm for lentigines in Asian skin. STUDY DESIGN/MATERIALS AND METHODS:This was a prospective, open-label cohort study, using a novel picosecond 532-nm laser for the treatment of facial lentigines. Subjects received up to...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.23103
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The current study (for which ethical approval was obtained) sought to assess the effect of low intensity monochromatic infrared therapy (LIMIRT) on experimentally induced delayed onset muscle soreness (DOMS). STUDY DESIGN/MATERIALS AND METHODS:Healthy volunteers were recruited (n = 24, 12M:12F...
journal_title：Lasers in surgery and medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1002/1096-9101(2001)28:1<33::AID-LSM1012>3.0.CO
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:There is an increasing interest in treating vascular lesions with a long-pulse Alexandrite laser. However, it is difficult to search information in the literature about infantile hemangiomas (IH) treated with long-pulse Alexandrite laser. This article aims to determine whether 755 nm long-pulse...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.22221
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Herein an overview is provided of the causes, consequences, and significance of photodynamic therapy (PDT)-mediated effects on tumor oxygenation and blood flow during illumination. STUDY DESIGN/MATERIALS AND METHODS:Techniques particularly valuable to this research have included tissue oxygen ...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章,评审
doi：10.1002/lsm.20355
更新日期：2006-06-01 00:00:00
abstract：:This paper describes the use of a pulsed argon laser to perform iridotomies in 87 patients. Diagnosis include: primary angle closure glaucoma, narrow angle in the fellow eye of patients with primary angle glaucoma, pupillary block, and after incomplete surgical iridectomies. Laser iridotomy was achieved in 79% of pati...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900010205
更新日期：1980-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Cosmeceuticals, chemical peels and collagen injections are used to rejuvenate skin, but none of these methods is effective or permanent. Recently, laser resurfacing has been found to be effective, but the incidence of side effects is relatively high. Two years ago, the non-ablative wrinkle red...
journal_title：Lasers in surgery and medicine
pub_type： 临床试验,杂志文章
doi：10.1002/lsm.10119
更新日期：2003-01-01 00:00:00
abstract：:The distribution of light in laser-irradiated biological medium is computed using four different procedures. Values computed with Beer's law of attenuation, Kubelka-Munk theory, the diffusion approximation, and a seven-flux model are compared. The proper conditions for using each model are discussed. ...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900060603
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The use of pulsed dye laser (PDL) and fractional CO2 (FX CO2 ) laser therapy to treat and/or prevent scarring following burn injury is becoming more widespread with a number of studies reporting reduction in scar erythema and pruritus following treatment with lasers. While the majority of studi...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.22702
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Fifty percent human albumin solder significantly improves weld strength when compared to lower concentrations [Wright et al., ASLMS meeting, April, 1995]. We developed a method for preparing 50% human albumin that may be considered compatible for clinical applications. STUDY DESIGN/MATERIALS A...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/(SICI)1096-9101(1996)19:1<2::AID-LSM1>3.0.
更新日期：1996-01-01 00:00:00
abstract：:Seven cases of cerebral tumors (four deep-seated sovratentorial gliomas located in motor area, occipital region, parietal region and frontal region; one deep-seated cystic cerebellar spongioblastoma; one sphenoidal wing meningioma, and one spinal cord intradural tumor) were simultaneously irradiated in the same area w...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900020205
更新日期：1982-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Laser soldering of tissues is based on the application of a biological solder on the approximated edges of a cut. Our goal was to use laser soldering for sealing cuts in skin under temperature feedback control and compare the results with ones obtained using standard sutures. STUDY DESIGN/MATE...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1118
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Current fat-graft animal models require weeks, to months, for results. The purpose of this study was to develop a model for the rapid identification of adipocyte protectants, using apoptosis-specific fluorescence. The goal of our model was to predict long-term fat graft survival within a 10-da...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.20874
更新日期：2009-12-01 00:00:00
abstract：:Low power laser irradiation has been reported to cause biological effects due to the photochemical and/or photophysical action of the radiation. This study determined quantitatively if transcutaneous low power laser irradiation can affect the regeneration of the rat facial nerve. The facial nerve was crushed unilatera...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900130113
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:While cryolipolysis initially received FDA clearance for fat reduction in the abdomen and flanks, there was significant interest in non-surgical fat reduction for other sites, such as the inner and outer thighs. This article reports the results of an inner thigh study which contributed to FDA ...
journal_title：Lasers in surgery and medicine
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1002/lsm.22320
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Although the empirical characteristics of ArF excimer laser corneal ablation have been well documented, the exact ablation mechanisms are not well understood. The present paper reports a quantitative analysis of corneal ablation plumes using in situ time resolved laser light scattering and Rama...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900160410
更新日期：1995-01-01 00:00:00
abstract：:This investigation was designed to compare standard scalpel transections of the tibial branch of the rat sciatic nerve with those performed using either a milliwatt carbon dioxide (CO2) or a potassium titanyl phosphate (KTP/532) laser. Four transection groups consisted of nerves sectioned with (1) scalpel (control), (...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900120109
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Severed tibial nerves in rats were repaired using a novel technique, utilizing a semiconductor diode-laser-activated protein solder applied longitudinally across the join. Welding was produced by selective laser denaturation of solid solder bands containing the dye indocyanine green. STUDY DES...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/(sici)1096-9101(1997)21:2<134::aid-lsm4>3.
更新日期：1997-01-01 00:00:00
abstract：:The argon fluoride excimer laser is investigated as a cutting-ablating tool for bone surgery. Quantitative measurements are presented for various fluences of laser energy and number of pulses. Histological data are presented that demonstrate the minimal damage to the surrounding material from the laser interaction. Co...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900110111
更新日期：1991-01-01 00:00:00
abstract：:The transport of biologically active material during laser cutting with CO2 and Er lasers is demonstrated. This transport mechanism removes particles from the surface of gelatin, agar, and liver samples into the depth of the laser-formed craters. The transport phenomenon is explained by a contraction and condensation ...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900080604
更新日期：1988-01-01 00:00:00
abstract：:Percutaneous endoscopic approaches to cholelithiasis would be facilitated by methods for welding gallbladder tissues. We evaluated the bursting pressure and histologic appearance of canine gallbladder tissue welded with a thulium-holmium-chromium:YAG (THC:YAG) laser producing a 2.15 microns pulsed output. The tissue a...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900090211
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:To evaluate the antiallergic effect of low-level laser irradiation (LLLI) at 650 nm in a mouse model of allergic rhinitis (AR), and to examine the underlying mechanisms. STUDY DESIGN/MATERIALS AND METHODS:BALB/c mice were sensitized with ovalbumin (OVA) and alum and challenged intranasally wi...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.23141
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:CO2 laser cordectomy has been the workhorse of laser surgery for early glottic squamous cell carcinoma (GSCC) since the early 1970s. During the last decades, potassium titanyl phosphate (KTP) laser surgery for early GSCC gained popularity, introducing the tumor ablation technique. Yet, there a...
journal_title：Lasers in surgery and medicine
pub_type：
doi：10.1002/lsm.23202
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Photodynamic therapy (PDT) has become one of the emerging options in management of cancer and other diseases. The major goal of PDT is to kill cancer cell without causing any adverse effect to the normal cells. PDT in combination of different therapeutic agents is being evaluated to improve the...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.22095
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:To evaluate the effects on disruption of hair growth of the non-coherent filtered flashlamp intense pulsed light (IPL) source. MATERIALS AND METHODS:Twenty-eight sites on 23 patients with Fitzpatrick type I-III were enrolled using a single treatment IPL followed for three months post-treatment...
journal_title：Lasers in surgery and medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1002/(sici)1096-9101(1999)24:2<128::aid-lsm8>3.
更新日期：1999-01-01 00:00:00
abstract：:Laser-induced fluorescence may be used to guide laser ablation of atherosclerotic lesions. This study was performed to evaluate arterial autofluorescence spectroscopy in vitro using a single XeCl excimer laser (308 nm) for simultaneous tissue ablation and fluorescence excitation. The laser beam was coupled to a 600-mi...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.1900140306
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Laser-induced photo thermal damage has been combined with photodynamic therapy (PDT) using a systemic photosensitiser to treat vascular lesions. The efficacy of PDT using systemic 5-aminolaevulinic acid (5-ALA) as the photosensitiser and pulsed dye laser (PDL) as the light source in port wine ...
journal_title：Lasers in surgery and medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1002/lsm.20151
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:Primary cutaneous amyloidosis (PCA) comprises three main forms: macular, lichen, and nodular amyloidosis. The current available treatments are quite disappointing. OBJECTIVES:Assess and compare the clinical and histological changes induced by different modes of Fractional CO2 laser in treatment of PCA. PAT...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章,随机对照试验
doi：10.1002/lsm.22361
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:Photodynamic therapy (PDT) using topical aminolevulinic acid (ALA) depends on local drug uptake, metabolism to porphyrins, and depth of light penetration using different wavelengths. Topical ALA-PDT has limited depth of drug penetration. We studied induced porphyrin distribution and PDT after intradermal ALA...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/lsm.21073
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Pyropheophorbide-a-hexyl ether (HPPH) is a new compound being investigated for use as a photosensitizer for photodynamic therapy; however, the pharmacokinetics are not known for any of the target species likely to be treated with this drug. The objective of this study was to determine the phar...
journal_title：Lasers in surgery and medicine
pub_type： 杂志文章
doi：10.1002/(SICI)1096-9101(1996)18:4<406::AID-LSM10>3
更新日期：1996-01-01 00:00:00
