MRI guided interstitial laser therapy in a rat malignant glioma model.

Abstract:

:We have used MR monitoring to guide and evaluate the effects of the Nd:YAG interstitial laser on a well-characterized rat brain tumor model (C6). MRI was used to determine the tumor size, verify the location of the interstitial probe, and evaluate the size and location of the laser-induced lesion during and after treatment. During laser irradiation, an irreversible loss of signal intensity at the fiber tip and a reversible decrease in signal intensity around it were observed with MRI. None of the treatment protocols affected mean rat survival significantly. Although MRI-guided interstitial laser therapy appears to be safe and easy, it does not provide a curative treatment for spatially disseminated gliomas where a "target volume" cannot be adequately defined. Better results can be expected, especially in well-defined tumors, with improvements of both the imaging techniques and the laser treatment protocol.

journal_name

Lasers Surg Med

authors

el-Ouahabi A,Guttmann CR,Hushek SG,Bleier AR,Dashner K,Dikkes P,Black PM,Jolesz FA

doi

10.1002/lsm.1900130502

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

503-10

issue

5

eissn

0196-8092

issn

1096-9101

journal_volume

13

pub_type

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