Burst firing induces a rebound of synaptic strength at unitary neocortical synapses.

Abstract:

:High-frequency activity produces transient depression at many synapses but also, as recently demonstrated, may accelerate the recovery from use-dependent depression. We have examined the possible consequences of this synaptic mechanism in neocortical excitatory synapses by recording simultaneously from presynaptic pyramidal neurons and their postsynaptic targets. Brief bursts of high-frequency spikes produced a strong depression of the amplitude of unitary excitatory postsynaptic currents (uEPSCs). However, when burst firing was combined with low-frequency ongoing activity, we found that the strong synaptic depression was followed by a transient rebound of synaptic strength. This rebound overshot the low-frequency baseline values and lasted 1-2 s. These results suggest that in the presence of ongoing activity, neocortical synapses may functionally facilitate following burst firing.

journal_name

J Neurophysiol

authors

Galarreta M,Hestrin S

doi

10.1152/jn.2000.83.1.621

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

621-4

issue

1

eissn

0022-3077

issn

1522-1598

journal_volume

83

pub_type

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