[Locoregional chemotherapy of liver metastasis from colorectal carcinoma].

Abstract:

:Hepatic metastases are a major cause of death in patients with colorectal carcinoma. Traditional intravenous chemotherapy produces responses in 10% to 30% of patients and surgical resection is feasible in approximately 20% of patients. Infusion of cytotoxic agents into the hepatic artery is the most promising form of therapy for unresectable hepatic metastases. The recent development of a totally implantable pump has allowed prolonged infusion of chemotherapeutic agents with a good compliance and quality of life of the patients. The rationale for hepatic arterial infusion (HAI) present an anatomical and pharmacological basis with the use of agents with high hepatic extraction resulting in minimal systemic toxicity. The results of eight randomized trial assessing the value of HAI Floxuridine shows that such regional chemotherapy increases the likelihood of hepatic response compared with systemic treatment (52% vs 15%). Survival information is difficult to evaluate because some of the studies are small, some had a crossover design and some others had bias factors. Extrahepatic disease develops in 40-70% of patients undergoing HAI; the use of systemic therapy plus HAI may produce a decrease in extrahepatic disease. Further studies of combined systemic/arterial regiment are necessary.

journal_name

Ann Ital Chir

authors

Zamparelli G,Pancera G,Pessi MA,Dallavalle G,Pirovano M,Valsecchi R,Labianca R,Samori G,Luporini G

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

793-7

issue

6

eissn

0003-469X

issn

2239-253X

journal_volume

67

pub_type

杂志文章,评审
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    authors: Miro AG,De Seta C,Arenga G,Russo M,Lombardi D

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    authors: Civello IM,Frontera D,Pittiruti M,Casale S,Zappalà S,Battista Doglietto G,Zucchetti F,Crucitti F

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    authors: Varricchio A,Schettino M,Ciampa A,Iannace C,Lo Conte D,Di Libero L,Donnarumma B,Vigorito R,Lepore M

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    doi:

    authors: Neola B,D'Ambra M,Capasso S,Russo M,Ferulano GP

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    authors: Migliore M

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  • Laparoscopic cholecystectomy: technical compromise between French and American approach. Presentation of an original technique.

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    journal_title:Annali italiani di chirurgia

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    doi:

    authors: Carlomagno N,Santangelo M,Romagnuolo G,Antropoli C,La Tessa C,Renda A

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    doi:

    authors: Continenza MA,Ricciardi G,De Nuntiis M,Rizzo FM,Rizzo GL

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  • [Role of diagnostic imaging in primary and secondary hyperparathyroidism].

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    doi:

    authors: Panzironi G,Franceschini L,De Cristofaro F,Angelini P

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  • [Colostomy control using an original occluding device. A clinico-experimental study].

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    journal_title:Annali italiani di chirurgia

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    doi:

    authors: Aglietti L,Cosenza UM,Aglietti A,Valdarnini D,Soranna V

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  • Agenesis of the gallbladder.

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    doi:

    authors: Nardello O,Muggianu M,Cagetti M

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  • [Perforated jejunal diverticulum. A case report].

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    doi:

    authors: Basile G,Buffone A,Boscarelli G,Maria S,Santagati G,Corsaro A,Cirino E

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  • An infection-oriented approach for thoracic endovascular aortic repair in a SARS-CoV-2 positive patient. A case report.

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    journal_title:Annali italiani di chirurgia

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    doi:

    authors: Rossi G,Ferrari SA,Sommaruga S,Muzzarelli L,Piconi S

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  • One stage curative resection of double intestinal neuroendocrine tumors with thirty-two bilobar liver metastases. A case report.

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    pub_type: 杂志文章

    doi:

    authors: Mirarchi M,De Raffele E,Cuicchi D,Lecce F,Cruciani G,Cola B

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  • [Pseudo-occlusions of the internal carotid artery].

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    doi:

    authors: Azzarone M,Berni Canani M,Nahas MA,Benincasa A,Salcuni PF,Tecchio T

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  • Aggressive angiomyxoma of the pelvis presenting as an obturator hernia.

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    journal_title:Annali italiani di chirurgia

    pub_type: 杂志文章

    doi:

    authors: Yalav O,Topal U,Unal AG,Erdogan KE

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  • Chronic pancreatitis: diagnosis and staging.

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    journal_title:Annali italiani di chirurgia

    pub_type: 杂志文章,评审

    doi:

    authors: Manes G,Kahl S,Glasbrenner B,Malfertheiner P

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  • Single incision laparoscopic surgery for hepatic hydatid disease. Report of a case.

    abstract::A 76 year-old female patient with a long-time history of nonspecific abdominal pain admitted to our hospital. Imaging studies showed 5 cm liver hydatid cyst between segments 2 and 3. She was recommended surgery and was informed about the details of single incision laparoscopic surgery (SILS). We performed single-incis...

    journal_title:Annali italiani di chirurgia

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    doi:

    authors: Karabicak I,Yuruker S,Seren DT,Kesicioglu T,Cinar H,Ozen N

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  • [Latent pathology of the thyroid: an epidemiological and statistical study of thyroids sampled during 507 consecutive autopsies].

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    doi:

    authors: Autelitano F,Santeusanio G,Mauriello A,Autelitano M,Palmieri G,Orlandi A,Spagnoli LG

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  • Does hyperbaric oxygen therapy reduce the effects of ischemia on colonic anastomosis in laparoscopic colon resection?

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    journal_title:Annali italiani di chirurgia

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    doi:

    authors: Emir S,Gurdal SO,Sozen S,Bali I,Yesildag E,Celik A,Guzel S,Sahin O,Ay H,Topcu B

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  • Impact of transthoracic endoscopic sympathectomy on plantar hyperhidrosis.

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    journal_title:Annali italiani di chirurgia

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    doi:

    authors: Paliogiannis P,Scognamillo F,Attene F,Pala C,Marrosu A,Pulighe F,Trignano M

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  • [Recurrence of stomach cancer following surgery].

    abstract::The purpose of this article is to review the incidence and characteristic of first recurrence in a group of 182 patients who underwent curative surgery with extended lymphadenectomy (> or = D2). The median follow up was 46.4 months (range 14-111). The incidence of relapses was 3.3% in the early gastric cancer and 50.8...

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    pub_type: 杂志文章

    doi:

    authors: Guglielmi A,de Manzoni G,Laterza E,Veraldi GF,Borzellino G,Di Leo A,Bonfiglio M

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  • A 16-year experience of carotid artery stenting for carotid artery stenosis.

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    doi:

    authors: Nano G,Stegher S,Occhiuto MT,Muzzarelli L,Malacrida G,Mazzaccaro DP

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    doi:

    authors: Cocorullo G,Tutino R,Falco N,Salamone G,Gulotta G

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    doi:

    authors: Chalazonitis AN,Tilentzoglou AC,Condilis N,Tzovara J,Porfyridis P,Ptohis N

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    abstract::The authors present clinical and instrumental results of N. 543 operations executed by CHIVA system. These cases are the result of trial performed in seven SIOC (Italian Society of CHIVA Operators) centers executed from November '87 to July '89. Functional and aesthetic results had been very good on over 85% of all ca...

    journal_title:Annali italiani di chirurgia

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Mandolesi S,Ballo M,Galeandro I,Filippo S,Migaldi D,Spinelli F,Nasso C,Carbone P,Scaramuzzino L,Passariello F

    更新日期:1990-07-01 00:00:00

  • Infections of the aorta and iliac arteries. Report of 20 years experience in a single centre.

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    doi:

    authors: Ferrante A,Cina A,Tsiopoulos VD,Snider F

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  • [A case of breast metastasis in bladder urothelioma].

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    doi:

    authors: Cannizzaro MA,Ferraù F,Mazzone G,Galasso MG,Veroux PF,De Maria A,Fazzi C,Failla G

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  • Vulvar endometriosis and Nuck canal.

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  • Metachronous solitary left adrenal gland metastasis of right colon cancer treated with laparoscopic approach.

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    abstract:BACKGROUND AND AIMS:vertical banded gastroplasty (GPV) is the most frequently performed restrictive procedure for morbid obesity, but long-term follow-up is almost nonexistent. A poor outcome after GPV and a low quality of life has been reported. The aim of the study was to determine long-term outcome after 5 years fol...

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    pub_type: 杂志文章

    doi:

    authors: Ghirardi M,Mittempergher E,Vassallo R,Terraroli C,Bruni O,Bruni T

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