Successful use of rFVIIa for major breast surgery prophylaxis in congenital factor VII deficiency: a case report.

Abstract:

INTRODUCTION:Factor VII deficiency is a rare cause of haemorrhagic syndrome. The Authors describe a case of a 46 years old patient with congenital factor VII deficiency that successfully underwent breast surgery after treatment with Novoseven® before the procedure. MATERIALS AND METHODS:The AA used the schedule reported below to value the levels of PT and aPTT in the patient. Blood Collection: Venous blood from patient and control was collected in glass tubes for routine serum preparation and into plastic tubes (0.129 M sodium citrate, Becton-Dickinson Vacutainer Systems) in a ratio of blood to anticoagulant of 9:1. Platelet Poor Plasma (PPP) was obtained by centrifugation at 4.000 x g for 15 minutes at room temperature. The plasma was recentrifuged for another 10 min at 12000 g to fully eliminate platelet concentration. A normal control plasma pool was prepared by mixing equal volumes of platelet-free plasma obtained from at least 50 normal volunteers. Prothrombin time (PT) was measured with Recombiplastin (IL, Milano Italy). Activated partial thromboplastin times (APTT) was measured with APTT-SP (IL, Milano Italy). They were performed on the coagulation analyzer ACL 1000 (IL, Milano Italy). RESULTS:The results were interpreted from the ratio of the patient times to the normal control times (Table I). CONCLUSION:The infusion of Novoseven solved the clotting problems enabling the surgical procedure, without risks for the patient.

journal_name

Ann Ital Chir

authors

Varricchio A,Schettino M,Ciampa A,Iannace C,Lo Conte D,Di Libero L,Donnarumma B,Vigorito R,Lepore M

subject

Has Abstract

pub_date

2014-06-25 00:00:00

issue

ePub

eissn

0003-469X

issn

2239-253X

pii

S2239253X14012109

journal_volume

85

pub_type

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