Abstract：
BACKGROUND:An increase in intra-abdominal pressure causes a decrease in the splanchnic blood flow and the intramucosal pH of the bowel, as well as increasing the risk of ischemia in the colon. The aim of the present study is to evaluate the effect of hyperbaric oxygen therapy (HBOT) on the ischemia caused by laparoscopy in colonic anastomosis in an experimental model of laparoscopic colonic surgery. MATERIALS AND METHODS:We divided 30 male Wistar albino rats into three groups: Group A was the control (open colon anastomosis); Group B received LCA (laparoscopic colon anastomosis); while Group C received both LCA and HBOT. Each group contained ten animals. We placed Group C (LCA and HBOT) in an experimental hyperbaric chamber into which we administered pure oxygen at 2.1 atmospheres absolute 100% oxygen for 60 min for ten consecutive days. RESULTS:The anastomotic bursting pressure value was found to be higher in the open surgery group (226 ± 8.8) (Group A). The result for Group C (213 ± 27), which received HBOT, was better than that for Group B (197 ± 27). However, there was no statistically significant difference between Group B and Group C. Group A showed better healing than the other groups, while significant differences in the fibroblast proliferation scores were found between Groups A and B. In terms of tissue hydroxyproline levels, a significant difference was found between Groups A and B and between Groups A and C, but not between Groups B and C. CONCLUSIONS:HBOT increases the oxygen level in the injured tissue. Although HBOT might offer several advantages, it had only a limited effect on the healing of colonic anastomosis in rats with increased intra-abdominal pressure in our study. KEY WORDS:Anastomosis, Colon, Hyperbaric Oxygen Treatment, Oxidative Stress. PREMESSA:Un aumento della pressione intraddominale determina una riduzione del flusso splancnico ed del pH intramucoso dell’intestino, come pure un aumentato rischio di eschemia dle colon. Lo scopo di questo studio è quello di valutare l’effetto della terapia con ossigeno iperbarico (HBOT) sull’ischemia provocata dalla laparoscopia sulle anastomosi Coliche in un modello sperimentale di chirurgia laparoscopica del colon. MATERIALE E METODO:Abbiamo diviso 30 ratti maschi Wistar albini in tre gruppi di 10 animali ciascuno: il Gruppo A di controllo (anastomosi colica ad addome aperto); il Gruppo B di anastomosi colica laparoscopica (LCA); il Gruppo C di anastomosi colica laparoscopica (LCA) trattato con HBOT. Il Gruppo C (LCA + HBOT) è stato introdotto in camera iperbarica con somministrazione di ossigeno puro al 200% a 2,1 atmosfere per 60’ per dieci giorni consecutivi. RISULTATI:Si è riscontrato che il valore della pressione di rottura dell’anastomosi è più elevata nel gruppo A (226 ± 8.8). Lo stesso valore nel Gruppo C, trattato con HBOT) (213 ± 27), è risultato migliore di quello nel Gruppo B (197 ± 27). Comunque non sono state rilevate differenze statistiche significative tra il Gruppo B ed il Gruppo C. Il Gruppo A ha mostrato guarigione migliore rispetto agli altri gruppi, mentre differenze significative relative alla proliferazione fibroblastica sono state rilevate tra Gruppo A e Gruppo B. In termini di livelli di idrossiprolina tissutale è stata rilevata una differenza significativa tra Gruppo A e Gruppo B e tra Gruppo A e Gruppo C, ma non tra Gruppo B e Gruppo C. CONCLUSIONI:La JBOT accresce il livello di ossigeno sui tessuto traumatizzati. Sebbene la HBOT potrebbe offrire numerosi vantaggi, essa nel nostro studio mostra solo effetti limitati sui processi di guarigione delle anastomosi del colon sui ratti sottoposti ad aumento della pressione intraaddominale.
journal_name
Ann Ital Chirjournal_title
Annali italiani di chirurgiaauthors
Emir S,Gurdal SO,Sozen S,Bali I,Yesildag E,Celik A,Guzel S,Sahin O,Ay H,Topcu Bsubject
Has Abstractpub_date
2016-01-01 00:00:00pages
83-91eissn
0003-469Xissn
2239-253Xpii
S0003469X16024611journal_volume
87pub_type
杂志文章abstract：:Melanoma is considered one of the most lethal cancers and surgical therapy of its pulmonary metastases is rarely indicated. The only hope for a successful surgical treatment of secondaries from melanoma is a radical resection. Considering the very frequent multiorgan involvement of melanoma metastases, surgery is usua...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,评审
doi：
更新日期：1998-07-01 00:00:00
abstract：:The purpose of this article is to review the incidence and characteristic of first recurrence in a group of 182 patients who underwent curative surgery with extended lymphadenectomy (> or = D2). The median follow up was 46.4 months (range 14-111). The incidence of relapses was 3.3% in the early gastric cancer and 50.8...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：AIMS:We aim to test and compare the effects of Flavonoids (Fs) and Centella asiatica (Ca), and the traditional treatment to find out which best deals with healing time, bleeding and pain in the treatment of chronic Anal Fissure (AF). Materials of Study: 98 outpatients were divided randomly into treated (either Fs or Ca...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2018-01-01 00:00:00
abstract：:Metastasis are the most common malignant lesions of the liver. Liver is the most common site of visceral metastasis from colo-rectal carcinoma. Only in few patients are the lesions surgically resectable for cure and standard intravenous chemotherapy produces a low response rate. An intrahepatic arterial device for reg...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,评审
doi：
更新日期：1994-05-01 00:00:00
abstract：BACKGROUND:From the first successful splenectomy performed in 1893 the trend, in the management of splenic injuries has been increasingly toward avoiding splenectomy in favor of splenic preservation, either operatively or nonoperatively. The aim of this study is to evaluate our experience in the management of splenic i...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Anal stenosis is a fibrous narrowing of the anal channel. It develops, in most cases, in the aftermath of proctologic surgical procedures with extensive anoderm excision or in the presence of chronic anal inflammation in patients with Crohn Disease. However rare, this condition is thoroughly debilitating for the patie...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,评审
doi：
更新日期：2018-01-01 00:00:00
abstract：:Carotid restenosis is defined as a new > 50% diameter-reducing lesion present in sites of previous surgery. The clinical aspects of this complication are strongly connected with their anatomopathologic evolution: fibromuscular hyperplasia in early recurrent disease, atherosclerotic degeneration in the later lesions. R...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：:Although the second most common site of the accessory spleen is the tail of the pancreas, intrapancreatic accessory spleens (IPAS) are rarely recognized radiologically. When an accessory spleen is located in the pancreas, it may mimic a hypervascular pancreatic tumor. We report a case of intrapancreatic accessory sple...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2020-01-08 00:00:00
abstract：BACKGROUND:Laparoscopic approach to patients with suspected small bowel obstruction (SBO) is not yet widely accepted nor clearly standardized; due to the absence of randomized trials, many questions still remain matter of debate. METHODS:By describing a single typical case of acute intestinal occlusive syndrome in a 8...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2014-04-07 00:00:00
abstract：AIM:This study aimed to compare the frequency and risk factors of de novo urinary incontinence (UI) following abdominal and vaginal hysterectomies for benign disease. METHODS:The study included patients without incontinence history who underwent abdominal or vaginal hysterectomy for benign indications. Incontinence st...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2019-01-01 00:00:00
abstract：:A new classification of gallstones is reported, which has interesting implications for diagnostic and therapeutic purposes. Gallstones have been divided according to "type" into the following categories: cholesterol (single, multiple), mixed, black pigment, brown pigment, combination and composite. In addition, gallst...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,评审
doi：
更新日期：1998-11-01 00:00:00
abstract：:Multiple endocrine neoplasia type 2 (MEN 2) is a rare autosomal dominant cancer syndrome. Forty to fifty percent of patients with MEN 2A develops pheochromocytoma. Surgeons treating these patients with pheochromocytoma have always been faced with question of whether to perform mono-or bilateral adrenalectomy and the t...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2014-09-01 00:00:00
abstract：:Venous leg ulcer is the most frequent cause of trophic lesions of the limbs in patients with chronic venous insufficiency. Appropriate management of cutaneous vascular lesions is based on systemic, vascular and local assessment. The Authors used a protease-modulating matrix in 126 patients suffering from venous leg ul...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2009-09-01 00:00:00
abstract：PURPOSE:Chemotherapeutic factors are known to affect healing on the postoperative patient. The aim of the present experimental study was to evaluate the effect of intraperitoneal infusion of 5-fluorouracil, bleomycin and cisplatin on the healing of colonic anastomoses in rats. METHODS:Forty Albino-Wistar male rats wer...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
abstract：:Breast cancer is a rare, but frequently hidden pathology. A woman, 36 years old, during the early months of pregnancy found a little tumor in her right breast. A fine needle biopsy was negative for cancer. Despite this, the tumor rose and two months after delivery (the patient breast-fed her daughter for a month), she...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2002-05-01 00:00:00
abstract：:Multinodular goitre is a very common pathology among people especially female adult and represents more than 90% of the thyroid surgery. We analyzed 37 patients, demonstrating that the whole gland is progressively affected by an incessant nodulogenesis and we confirm the necessity of total thyroidectomy in order to el...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,评审
doi：
更新日期：2003-03-01 00:00:00
abstract：:The authors refer to three cases of congenital dilatation of the biliary system in an adult, an extremely rare pathology in the West, with no specific symptomatology, and therefore often discovered accidentally and unexpectedly The first patient had suffered from unexplained periods of fever since childhood, the secon...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2011-11-01 00:00:00
abstract：AIM:Health-status of elderly patients with hepatocellular carcinoma (HCC) may limit surgical approach; other options are thus auspicable. METHODS:The authors reviewed 98 selected patients, aged 65 to 90 years, with 149 HCC treated between 2002 and 2011. According to the extent of malignancy, health status and treatmen...
journal_title：Annali italiani di chirurgia
pub_type： 临床试验,杂志文章
doi：
更新日期：2014-03-01 00:00:00
abstract：:Although skin burns at the site of grounding pad are a known risk of surgery, their exact incidence is unknown. We first report the case of a patient who presented a deep gluteal burn at the site of the grounding pad after an abdominal aortic aneurism repair, the etiology and the challenging treatment required to over...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2015-06-24 00:00:00
abstract：:Gas within the wall of the stomach (emphysematous gastritis) is a rare condition associated with systemic toxicity and very often mortal end. The etiology includes firstly infections with gas-foaming organisms, other predisposing causes are the ingestion of corrosive substances, alcohol abuse and immunosuppression. Bu...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2005-05-01 00:00:00
abstract：:In this study the authors examined the influence of 71, beta-estradiol on cutaneous fibroblasts taken off either from healthy patients with no family history for cancer, or from patients with breast cancer. Fibroblasts were taken from the subcutaneous tissue of the mammary gland by a biopsy carried out in each patient...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：BACKGROUND:The treatment of acute diverticulitis is a matter of debate and has undergone significant changes. Currently the main focus of surgical treatment is a more conservative and less invasive management. AIMS AND METHODS:To focus the role of surgery in the treatment of acute diverticulitis, the Authors have cond...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,评审
doi：
更新日期：2019-01-01 00:00:00
abstract：AIM:We report our experience of carotid artery stenting (CAS) for the endovascular treatment of significant carotid stenosis over 16 years. MATERIALS AND METHODS:Data of all consecutive patients who came for a significant carotid artery stenosis from January 1st 1999 to August 31st 2015 were retrospectively collected ...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2016-01-01 00:00:00
abstract：:Removal of a giant fibroid during a caesarean section is very rare. We report a case of multiple myomectomy among which a huge myomas (cm 22, weight 3.000 g) in a 44 years old nullipara at 38 weeks. A 10 cm long suprapubic transversal incision according to Pfannenstiel on spinal anaesthesia was done; a female baby wei...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：AIM OF THE STUDY:To estimate our 3-year experience on the diagnosis and monitoring of the spleen traumatic lesions with the employment of ultrasound microbubbles contrast. METHOD:From the 174 patients who were joints to our department in regimen of urgency for abdominal traumatic lesions, we have estimated 24 patiens ...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:The problem of relationship between obesity and psychological distress is debated in the literature wherein a lot of studies exists with controversial results. The phenomenon of obesity is actually considered with criteria aimed to evaluate almost exclusively the weight excess. Even if such criteria have the advantage...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,评审
doi：
更新日期：2005-09-01 00:00:00
abstract：:Neuroendocrine tumours (NETs) of the midgut are often multifocal and have a noticeable attitude to metastasize to locoregional lymph nodes and liver. Surgery is the only curative treatment for metastatic NETs of the midgut, even though only a minority of patients are candidates to radical surgical resection. The optim...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2015-07-01 00:00:00
abstract：AIM OF THE STUDY:The superior pedicle mammaplasty is a technique frequently employed in the treatment of breast ptosis, associated or not with hypertrophy of the gland, followed by satisfactory results. This technique is normally not indicated in severe breast ptosis (pendulous breast) because of the excessive length o...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2007-11-01 00:00:00
abstract：:Combined modality treatments are indicated for most patients with breast cancer. The definition of a proper treatment schedule and of the timing of each modality is a relevant issue that affects the feasibility and the clinical outcome of the treatment. A review of the literature was done on the timing of radiation th...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,评审
doi：
更新日期：1999-05-01 00:00:00
abstract：OBJECTIVES:The objective of our study was to determine the predictive factors of their occurrence during conservative surgical treatment of the hepatic hydatid cyst (HHC). PATIENTS AND METHODS:We carried out a retrospective review of patients who had undergone conservative surgical treatment of the HHC during 6 years....
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2019-01-01 00:00:00
