Nail matrix arrest following hand-foot-mouth disease: a report of five children.

Abstract:

:Hand-foot-mouth disease (HFMD) is a contagious enteroviral infection occurring primarily in children and characterized by a vesicular palmoplantar eruption and erosive stomatitis. Nail matrix arrest has been associated with a variety of drug exposures and systemic illnesses, including infections, and may result in a variety of changes, including transverse ridging (Beau's lines) and nail shedding (onychomadesis). The association of HFMD with Beau's lines and onychomadesis has not been reported previously. Five children, ages 22 months-4 years, presented with Beau's lines and/or onychomadesis following physician-diagnosed HFMD by 3-8 weeks. Three of the five patients experienced fever with HFMD, and none had a history of nail trauma, periungual dermatitis, periungual vesicular lesions, or a significant medication intake history. All patients experienced HFMD within 4 weeks of one another, and all resided in the suburbs of the Chicago metropolitan area. In all patients the nail changes were temporary with spontaneous normal regrowth. The mechanism of the nail matrix arrest is unclear, but the timing and geographic clustering of the patients suggests an epidemic caused by the same viral strain.

journal_name

Pediatr Dermatol

journal_title

Pediatric dermatology

authors

Clementz GC,Mancini AJ

doi

10.1046/j.1525-1470.2000.01702.x

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

7-11

issue

1

eissn

0736-8046

issn

1525-1470

pii

pde1702

journal_volume

17

pub_type

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