Abstract:
:The Goeckerman regimen (GR) represents a local treatment of psoriasis and includes topical dermal application of crude coal tar (containing polycyclic aromatic hydrocarbons) and exposure to UV-irradiation. The aim of the study was to evaluate contribution of GR to genotoxic risk and cellular stress in pediatric patients who represent a sensitive population subgroup. Genotoxic risk (42 patients) was evaluated by using chromosomal aberrations (CA) in peripheral lymphocytes. Cellular stress (26 patients) was assessed by using heat shock proteins (Hsp70). All indicators were determined in blood samples collected before GR and immediately after GR. Decreasing of psoriasis area and severity index (PASI) score indicated higher likelihood of GR (p < 0.001). Significantly increased CA (p < 0.001) and Hsp70 (p < 0.05) indicated higher genotoxic risk and cellular stress in sensitive pediatric patients, immediately after GR.
journal_name
Pediatr Dermatoljournal_title
Pediatric dermatologyauthors
Borska L,Andrys C,Krejsek J,Hamakova K,Kremlacek J,Ettler K,Vellappally S,Vimal J,Fiala Zdoi
10.1111/j.1525-1470.2008.00774.xsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
23-7issue
1eissn
0736-8046issn
1525-1470pii
PDE774journal_volume
26pub_type
杂志文章abstract:BACKGROUND/OBJECTIVES:Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are medical emergencies. Mainstays of treatment include removal of the offending agent, supportive care, and wound care. The use of immunosuppressive agents such as corticosteroids and intravenous immunoglobulin (IVIg) is controve...
journal_title:Pediatric dermatology
pub_type: 杂志文章
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abstract::Onychomycosis is widespread in the adult population, but considered to be rare in children. A number of studies in recent years show a rise in the prevalence of toenail onychomycosis in children. Of these, only a few were population-based. Here, we present a comprehensive cross-sectional population-based survey of toe...
journal_title:Pediatric dermatology
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abstract::Hemangiomas are classified as focal or segmental according to the morphology and distribution of lesions. Congestive cardiac failure is frequently encountered in diffuse hepatic hemangiomas due to high-volume shunting and rarely in hemangiomas confined to the skin. We report here the case of a large multifocal hemangi...
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更新日期:2015-01-01 00:00:00
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journal_title:Pediatric dermatology
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更新日期:1991-12-01 00:00:00
abstract::Demodex mites are commensal inhabitants of the pilosebaceous unit that are typically absent or at low numbers in childhood. When they are present, they can cause a primary eruption or exacerbate an underlying facial dermatosis. Here we report five cases of demodicosis occurring in childhood, the clinical presentations...
journal_title:Pediatric dermatology
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doi:10.1111/pde.13852
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abstract::A newborn girl had typical "blueberry muffin" skin lesions, which showed histopathologic features of myelomonocytic leukemia cutis. We could not demonstrate leukemic infiltration of bone marrow in four aspirates. Her course was complicated with primary pulmonary hypertension, which led to death at 7 months of age. We ...
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journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2011.01677.x
更新日期:2012-05-01 00:00:00
abstract::Tuberous sclerosis complex is an autosomal dominant disorder that often manifests early in life with cutaneous features, and it is important that dermatologists who care for children remain up to date on its diagnosis and management. This article provides an update regarding the most recent guidelines for diagnosis pu...
journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
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journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
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更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Dermatologic conditions comprise a significant number of emergency department visits in the pediatric population in the United States. Understanding key predictors of emergency department utilization for dermatologic conditions is important to reduce inappropriate use. METHODS:A total of 44 554 sampled pati...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.14476
更新日期:2020-12-18 00:00:00
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journal_title:Pediatric dermatology
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更新日期:2019-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1525-1470.2001.018001041.x
更新日期:2001-01-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.14257
更新日期:2020-09-01 00:00:00
abstract::A 14-year-old boy presented with extensive capillaritis. Narrow-band ultraviolet B was administered on a thrice-weekly schedule followed by once-a-week maintenance. A favorable response to treatment was seen without any side effects. ...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2012.01806.x
更新日期:2013-11-01 00:00:00
abstract::This is a follow-up report on a boy with phacomatosis pigmentokeratotica. At the age of 10 years he had, in addition to a sebaceous nevus and a speckled lentiginous nevus, multiple lesions of a collagen nevus localized on the chin and in the lumbar area. On the left shoulder, a small telangiectatic spot was present wi...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2007.00588.x
更新日期:2008-01-01 00:00:00
abstract::We describe a unique and puzzling case of a 7-month-old baby with a non-X hypertriglyceridemic histiocytoxanthomatosis. The disease was characterized by a massive nodular eruption that was clinically, histologically, and ultrastructurally consistent with juvenile xanthogranuloma, but it had a rapid, fatal evolution. ...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.1987.tb00787.x
更新日期:1987-11-01 00:00:00
abstract::Orf is a zoonotic parapoxvirus typically transmitted to humans by a bite from goats or sheep. We present an unusual case of multiple orf lesions on the fingers of a 13-month-old child who was bitten by a goat and subsequently developed progressive swelling, blistering, and necrotic papulonodules of the hand followed b...
journal_title:Pediatric dermatology
pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
abstract::A male infant with skin lesions was born to a 28-year-old mother who was under treatment for pemphigus vulgaris (PV), diagnosed eight years earlier. Circulating IgG class pemphigus antibody was found in the infant's blood, and deposition of IgG in the intercellular spaces of the epidermis was seen. The infant's lesion...
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pub_type: 杂志文章
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更新日期:1986-12-01 00:00:00
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journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
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更新日期:1999-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
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journal_title:Pediatric dermatology
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更新日期:2017-05-01 00:00:00
abstract::Although many cases of follicular mucinosis are idiopathic, numerous others are associated with mycosis fungoides or, rarely, other neoplastic or inflammatory disorders. There are only three reported cases, all in adults, of follicular mucinosis arising in association with acute myelogenous leukemia, two of which invo...
journal_title:Pediatric dermatology
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更新日期:2016-01-01 00:00:00
abstract::We treated a 5-year-old boy with clear-cell hidradenoma of the forearm. Our literature search found only one previous report of this disease occurring during the first decade of life, and the present patient is the first with involvement of the limbs. This presentation demonstrates that clear-cell hidradenoma needs to...
journal_title:Pediatric dermatology
pub_type: 杂志文章
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更新日期:2005-09-01 00:00:00
abstract::We cared for 124 pediatric patients with a histologic diagnosis of Langerhans' cell histiocytosis (histiocytosis X) over a period of 14 years. Clinical, laboratory, and radiographic findings were analyzed. The most frequent manifestations were bone lesions, lymph node involvement, and skin infiltration. Liver disease ...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.1988.tb01160.x
更新日期:1988-08-01 00:00:00
abstract::Molluscum contagiosum is a common viral infection of the skin that frequently affects children. Lesions take between 6 and 18 months to resolve spontaneously and are a source of great embarrassment to both caretakers and children, often affecting attendance at school and limiting social activity. Treatment options to ...
journal_title:Pediatric dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1525-1470.2006.00235.x
更新日期:2006-05-01 00:00:00
abstract::Xanthoma disseminatum is a rare, usually self-healing dermatologic disease of unknown etiology. Involvement of other organs and tissues including bone marrow, bone, and brain may be seen rarely in children. However, to date, hepatic involvement has not been reported. We describe a child with xanthoma disseminatum who ...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2005.00138.x
更新日期:2005-11-01 00:00:00
abstract::Acrodynia, also known as pink disease, erythredema polyneuropathy, Feer syndrome, and raw-beef hands and feet, is thought to be a toxic reaction to elemental mercury and less commonly to organic and inorganic forms. Occurring commonly in the early 20th century, acrodynia is now a seemingly extinct disease in the moder...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2012.01737.x
更新日期:2012-03-01 00:00:00
abstract::Mutations in the keratinocyte lipid transporter adenosine triphosphate-binding cassette A12 (ABCA12) are known to cause harlequin ichthyosis. More recently, mutations in this gene have been demonstrated to cause other phenotypes within the spectrum of recessive congenital ichthyosis. We report the case of an infant wi...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2011.01695.x
更新日期:2013-11-01 00:00:00