Primary sclerosing cholangitis: evaluation with MR cholangiography-a case-control study.

Abstract:

PURPOSE:To determine the accuracy of magnetic resonance (MR) cholangiography for detection of primary sclerosing cholangitis (PSC) and localization of PSC in the biliary tract. MATERIALS AND METHODS:In a prospective case-control study involving 102 patients, the MR cholangiograms obtained in 34 patients with PSC established with endoscopic retrograde cholangiopancreatography (ERCP) were compared with the MR cholangiograms obtained in 68 age-matched control patients with hepatobiliary diseases other than PSC. Two abdominal radiologists conducted an independent, blinded random review of the MR cholangiograms to assess for the presence or absence of PSC and determine the location of PSC in the biliary tract, and then compared the findings with those at ERCP. RESULTS:MR cholangiography was found to be accurate in detecting PSC and in defining the extent of disease. In the detection of PSC, the sensitivities were 88% and 85%; specificities, 97% and 92%; positive predictive values, 94% and 85%; and negative predictive values, 94% and 93% for readers 1 and 2, respectively. Interobserver agreement was excellent (kappa = 0.79). In the localization of extrahepatic PSC, the sensitivities were 83% and 89%; and specificities, 83% and 83% for readers 1 and 2, respectively. Interobserver agreement was good (kappa = 0.62). In the localization of intrahepatic PSC, the sensitivity was 87% for both readers; interobserver agreement was good (kappa = 0.71). CONCLUSION:MR cholangiography enables accurate detection and localization of PSC.

journal_name

Radiology

journal_title

Radiology

authors

Fulcher AS,Turner MA,Franklin KJ,Shiffman ML,Sterling RK,Luketic VA,Sanyal AJ

doi

10.1148/radiology.215.1.r00ap2671

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

71-80

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

215

pub_type

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