Abstract:
:In the redistribution of cells through the division cycle between dose fractions, the sensitizing effect is greatest when small doses per fraction are used. Since nonproliferating tissues limit the dose in radiotherapy and will not be sensitized by redistribution, the more the dose is fractionated and the lower the dose per fraction, the better. However, regenerative response in the tumor could limit its radiocurability if overall treatment time were protracted. This could be circumvented if two or more fractions were given daily, allowing time for redistribution; the probability of irradiating cycling cells in sensitive phases would then be increased.
journal_name
Radiologyjournal_title
Radiologyauthors
Withers HRdoi
10.1148/114.1.199subject
Has Abstractpub_date
1975-01-01 00:00:00pages
199-202issue
1eissn
0033-8419issn
1527-1315journal_volume
114pub_type
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