Corneal endothelial protection by different viscoelastics during phacoemulsification.

Abstract:

PURPOSE:To evaluate corneal endothelium morphology and function after phacoemulsification using different viscoelastics. SETTING:Eye Clinic, University of Trieste, Italy. METHODS:This prospective, randomized study included results of preoperative and postoperative (7, 30, and 90 days) examinations of 66 patients scheduled for phacoemulsification without ocular pathology; 8 patients were excluded. Patients were randomly assigned to one of four groups based on type of viscoelastic used: 1% sodium hyaluronate (Healon); 1.4% sodium hyaluronate (Healon GV); 4% sodium chondroitin sulfate-3% sodium hyaluronate (Viscoat); 2% hydroxypropyl methylcellulose (Hymecel). Mean cell density and cell size variation coefficient were determined by specular microscopy; central corneal thickness, by ultrasonic pachymetry; and endothelial permeability coefficient and active pump function, by anterior segment fluorophotometry. RESULTS:There were no significant differences in postoperative mean cell loss among the groups. The cell size variation coefficient was altered in all groups 7 days after surgery and was still impaired at 30 days in the Hymecel group. A significant increase in mean corneal thickness, endothelial permeability, and active pump function occurred in the Healon and Hymecel groups 7 days after surgery. These parameters were still altered 30 days after surgery in the Hymecel group. Endothelial functional alterations did not occur in the Healon GV or Viscoat group. CONCLUSION:Viscoat and Healon GV are effective in minimizing functional damage of endothelial structure in the early medium-term postoperative period.

authors

Ravalico G,Tognetto D,Baccara F,Lovisato A

doi

10.1016/s0886-3350(97)80190-3

subject

Has Abstract

pub_date

1997-04-01 00:00:00

pages

433-9

issue

3

eissn

0886-3350

issn

1873-4502

pii

S0886-3350(97)80190-3

journal_volume

23

pub_type

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