Abstract:
PURPOSE:To evaluate intrastromal concentrations of riboflavin with and without epithelium to ensure the efficacy and safety of corneal crosslinking (CXL) by the standard and transepithelial procedures. SETTING:Department of Ophthalmology and Department of Pharmacology G. Segre, Siena University, Siena, Italy. METHODS:This study comprised keratoconic patients enrolled for penetrating keratoplasty (PKP) and warm-stored sclerocorneal rings unsuitable for transplantation. Half the PKP specimens were debrided, and half were left with the epithelium in situ. One of the latter and 1 debrided sample were not exposed to riboflavin (controls). Samples in both groups were soaked with 0.1% riboflavin-dextran 20% solution instilled every 2 minutes for 5, 15, and 30 minutes. Riboflavin concentrations were determined by high-performance liquid chromatography (HPLC). RESULTS:The study evaluated 14 PKP specimens and 16 sclerocorneal rings. Control samples did not show a riboflavin emission peak. In exposed samples with epithelium, the mean riboflavin concentration was 91.88 ng/g after 5 minutes of exposure, 95.60 ng/g after 15 minutes, and 94.92 ng/g after 30 minutes. In the debrided samples, the mean riboflavin concentration was 14.42 microg/g, 20.92 microg/g, and 24.06 microg/g, respectively. No differences were seen between the in vivo samples and the ex vivo samples. CONCLUSIONS:The HPLC quantitative study showed that stromal concentrations of riboflavin increased with exposure time only if the epithelium was removed. A theoretically safe and effective riboflavin concentration of 15 microg/g was obtained for ultraviolet A-induced CXL only after the epithelium was removed and after at least 10 minutes of riboflavin application every 2 minutes.
journal_name
J Cataract Refract Surgjournal_title
Journal of cataract and refractive surgeryauthors
Baiocchi S,Mazzotta C,Cerretani D,Caporossi T,Caporossi Adoi
10.1016/j.jcrs.2009.01.009subject
Has Abstractpub_date
2009-05-01 00:00:00pages
893-9issue
5eissn
0886-3350issn
1873-4502pii
S0886-3350(09)00132-1journal_volume
35pub_type
杂志文章abstract::We evaluated two topical cyclo-oxygenase inhibitors (COIs), 0.03% flurbiprofen and 1% indomethacin, for their ability to prevent pseudophakic cystoid macular edema (CME). The study was a randomized, double-masked, vehicle-controlled, parallel group, clinical trial for six months at eight sites in Canada and two in Ger...
journal_title:Journal of cataract and refractive surgery
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0886-3350(13)80484-1
更新日期:1995-01-01 00:00:00
abstract::We describe a case of corneal chromoblastomycosis with Cladophialophora carrionii in a 69-year-old woman 4 weeks after clear corneal cataract surgery. The patient presented with right eye pain and decreased visual acuity of 20/100. Examination showed a deep posterior stromal keratitis accompanied by a dense fibrinous ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2011.03.007
更新日期:2011-05-01 00:00:00
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journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jcrs.2007.05.041
更新日期:2007-10-01 00:00:00
abstract::A 78-year-old woman developed a severe fibrinous anterior chamber reaction 1 day after uneventful clear corneal incision cataract extraction with intraocular lens implantation. There was no history of uveitis or diabetes, and the fibrin responded immediately to topical steroids. The patient was followed closely to rul...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(03)00075-0
更新日期:2003-08-01 00:00:00
abstract::Safe, effective administration of local anesthesia prior to ocular surgery is a primary concern of ophthalmologists and variations in the technique and method of delivering anesthesia have been developed. Retrobulbar anesthesia, although considered safe and effective, can have serious complications. Using periocular a...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(13)80861-9
更新日期:1991-07-01 00:00:00
abstract:PURPOSE:To determine whether vault measurements after placement of a hole implantable collamer lens (hole ICL) (KS-AquaPORT) can be predicted by angle-to-angle (ATA) and white-to-white (WTW) measurements obtained with anterior segment optical coherence tomography (AS-OCT). SETTING:Sanno Hospital, Tokyo, Japan. DESIGN...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
abstract:PURPOSE:To investigate the effects of phacoemulsification in glaucomatous eyes with functioning Baerveldt tube shunts. SETTING:Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. METHODS:This retrospective analysis followed 9 eyes of 8 patients with functioning Baerveldt tube shun...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2006.04.008
更新日期:2006-09-01 00:00:00
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journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章,meta分析
doi:10.1016/j.jcrs.2011.05.043
更新日期:2011-12-01 00:00:00
abstract::Carbachol instilled in 125 eyes at the time of extracapsular cataract extraction and posterior chamber lens insertion had a statistically significant effect on lowering the postoperative intraocular pressure (IOP) at 24 hours (average IOP 14.0 mm Hg) and at 72 hours (average IOP 11.6 mm Hg) (P less than .001). The per...
journal_title:Journal of cataract and refractive surgery
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更新日期:1988-11-01 00:00:00
abstract::Two patients with active iritis developed cataracts and had successful cataract surgery with implantation of a Collamer (Staar Surgical, AG) intraocular lens (IOL). Both patients developed severe bilateral uveitis, which in 1 patient was refractory to control. Different IOL materials have been used in iritis patients ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(03)00329-8
更新日期:2003-12-01 00:00:00
abstract:PURPOSE:To determine whether donor eyes had previous refractive surgery using Orbscan (Bausch & Lomb Surgical) corneal topography. SETTING:Lions Eye Bank of Oregon, Portland, Oregon, USA, and Maisonneuve-Rosemont, Hospital, Montreal, Quebec, Canada. METHODS:Orbscan corneal topographies of 50 donor eyes from the Lions...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2005.12.035
更新日期:2006-02-01 00:00:00
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journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
abstract::Eighty-two keratotomy procedures were performed for both idiopathic and postsurgical astigmatism or myopic astigmatism and analyzed for efficacy using vector and linear regression analysis. Delta keratometry values (delta K) were computed for each case as delta K in the desired axis of effect using vector analysis. Si...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(89)80134-8
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:To compare the efficacy and safety of anterior capsulotomy creation with a new selective laser device (CAPSULaser) with those of manual capsulotomies. SETTING:GEMINI Eye Clinic, Zlin, Czech Republic. DESIGN:Prospective case series. METHODS:Patients were placed in cohorts based on age and cataract grade and r...
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更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To describe surface scattering, a new phenomenon in polyacrylic intraocular lenses (IOLs), and discuss the possible cause of this finding. SETTING:Showa University, Fujigaoka Hospital, Yokohama, Kanagawa, Japan. METHODS:This observational case series involved 40 patients who received the AcrySof(R) IOL (Alcon...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(02)01994-6
更新日期:2003-07-01 00:00:00
abstract:PURPOSE:To evaluate visual and refractive outcome of microincision cataract surgery (MICS) with implantation of an Acri. Smart 48S intraocular lens (IOL) (Acri.Tech) through a sub-1.9 mm incision. SETTING:Vissum/Instituto Oftalmologico de Alicante and Ophthalmology Department, Miguel Hernandez University, Alicante, Sp...
journal_title:Journal of cataract and refractive surgery
pub_type: 临床试验,杂志文章
doi:10.1016/j.jcrs.2005.01.030
更新日期:2005-08-01 00:00:00
abstract::An alternative technique to manage pediatric cataracts comprises a pars plana lensectomy and anterior vitrectomy with anterior and posterior capsulotomies and posterior chamber heparin-surface-modified intraocular lens (IOL) implantation in the ciliary sulcus through a scleral tunnel. The surgical results in 7 eyes of...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(00)00298-4
更新日期:2000-04-01 00:00:00
abstract:PURPOSE:To evaluate the visual, refractive, contrast sensitivity, and aberrometric outcomes as well as the patient quality of life and photic phenomena disturbances after cataract surgery with implantation of a new trifocal toric intraocular lens (IOL). SETTINGS:Premium Clinic, Regional Hospital in Havlickuv Brod, Cze...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
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abstract:PURPOSE:To use the double-pass technique to evaluate the in vitro optical quality of foldable monofocal intraocular lenses (IOLs) used to correct aphakia. SETTING:Universitat Politècnica de Catalunya, Terrassa, and Instituto de Microcirugía Ocular de Barcelona, Barcelona, Spain; Universidad Nacional de Tucumán, Tucumá...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2009.03.022
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:To evaluate transient increases in intraocular pressure (IOP) after use of high-viscosity viscoelastic agents in cataract surgery. SETTING:Military Hospital, Ulm, Germany. METHODS:In a prospective, randomized study, we evaluated IOP following cataract surgery using two different viscoelastic substances (Healo...
journal_title:Journal of cataract and refractive surgery
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-03-01 00:00:00
abstract:PURPOSE:To compare epithelial remodeling in keratoconic eyes that had photorefractive keratectomy and corneal collagen crosslinking (Athens protocol) with that in untreated keratoconic eyes and healthy eyes. SETTING:Private clinical practice, Athens, Greece. DESIGN:Comparative case series. METHODS:Fourier-domain ant...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2014.02.036
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To compare the susceptibility and efficacy of 3 fluoroquinolones, (levofloxacin, gatifloxacin, and moxifloxacin) in treating conjunctival bacteria in patients having ocular surgery. SETTING:Osaka University Hospital, Osaka, and Tohoku University Hospital, Miyagi, Japan. METHODS:Eyes of patients were examined ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2008.11.049
更新日期:2009-03-01 00:00:00
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journal_title:Journal of cataract and refractive surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0886-3350(01)01122-1
更新日期:2002-01-01 00:00:00
abstract:UNLABELLED:We describe several simple modifications of the big-bubble technique to improve surgeon comfort and reduce the risk for complications, with emphasis on our ophthalmic viscosurgical device (OVD)-assisted incision technique. By coating the overlying stroma with OVD prior to entering the big bubble, space is ma...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2011.09.014
更新日期:2011-11-01 00:00:00
abstract::We report a patient who developed an anaphylactic reaction several minutes after intracameral injection of cefuroxime at the end of uneventful phacoemulsification and intraocular lens implantation surgery. The patient had a known allergy to penicillin but not to cefuroxime. This rare life-threatening complication was ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2013.06.008
更新日期:2013-09-01 00:00:00
abstract::Cataract extraction with posterior chamber intraocular lens implantation is rarely complicated by an acute, sterile, anterior segment inflammation. We report three unrelated cases of acute intraocular inflammation following uncomplicated cataract extraction and posterior chamber intraocular lens placement. A constella...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/s0886-3350(13)80929-7
更新日期:1992-03-01 00:00:00
abstract:PURPOSE:To evaluate the safety and efficacy of Intacs inserts in keratoconic eyes to alter corneal shape and refractive power and stabilize the progression of corneal ectasia. SETTING:Service d'Ophtalmologie, Bordeaux, France. METHODS:In this prospective study, 57 eyes with clear central corneas that were diagnosed w...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jcrs.2006.01.064
更新日期:2006-05-01 00:00:00
abstract:PURPOSE:To evaluate surgically induced corneal astigmatism after small superotemporal and superonasal clear corneal incision cataract surgery. SETTING:Department of Ophthalmology, School of Medicine, University of Afyon Kocatepe, Afyon, Turkey. METHODS:This prospective study comprised 56 eyes of 28 patients who had b...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2003.11.034
更新日期:2004-06-01 00:00:00
abstract:PURPOSE:To use anterior segment optical coherence tomography (AS-OCT) to evaluate anterior chamber depth (ACD) and angle after phacoemulsification and intraocular lens (IOL) implantation. SETTING:Department of Ophthalmology, Yeditepe University, Istanbul, Turkey. METHODS:Forty-seven eyes (37 patients) had uneventful ...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2008.05.049
更新日期:2008-10-01 00:00:00
abstract:PURPOSE:To determine the risk factors, intraoperative and postoperative complications, therapeutic interventions, and visual outcomes for persistent postoperative inflammation in primary resident-performed cataract surgeries. SETTING:Ben Taub General Hospital, Houston, Texas, USA. DESIGN:Retrospective case series. M...
journal_title:Journal of cataract and refractive surgery
pub_type: 杂志文章
doi:10.1016/j.jcrs.2018.05.006
更新日期:2018-07-01 00:00:00