Hematopoietic stem cell-based gene therapy for acquired immunodeficiency syndrome: efficient transduction and expression of RevM10 in myeloid cells in vivo and in vitro.

abstract：:HSCs are defined by their ability to self-renew and maintain hematopoiesis throughout the lifespan of an organism. The optical clarity of their embryos and the ease of genetic manipulation make the zebrafish (Danio rerio) an excellent model for studying hematopoiesis. Using flow cytometry, we identified 2 populations ...

journal_title：Blood

authors： Ma D,Zhang J,Lin HF,Italiano J,Handin RI

更新日期：2011-07-14 00:00:00

abstract：:Despite matching for serologically defined HLA-A, B, DR antigens, acute graft-versus-host disease (GVHD) is a major complication contributing to increased morbidity and mortality in patients who undergo marrow transplantation from unrelated donors. The extent to which unrecognized mismatching for alleles that encode D...

journal_title：Blood

authors： Petersdorf EW,Longton GM,Anasetti C,Martin PJ,Mickelson EM,Smith AG,Hansen JA

更新日期：1995-08-15 00:00:00

abstract：:Current approaches for treatment of late-stage breast cancer rarely result in a long-term cure. In part this is due to tumor stroma that prevents access of systemically or intratumorally applied therapeutics. We propose a stem cell gene therapy approach for controlled tumor stroma degradation that uses the pathophysio...

journal_title：Blood

authors： Li Z,Liu Y,Tuve S,Xun Y,Fan X,Min L,Feng Q,Kiviat N,Kiem HP,Disis ML,Lieber A

更新日期：2009-05-28 00:00:00

abstract：:The effects of human recombinant erythropoietin (rEpo) in the presence of other stimulators on the growth of clonogenic leukemic blast cells from ten Japanese patients with acute myeloblastic leukemia were studied with an in vitro leukemic blast colony assay in methylcellulose culture. With the addition of rEpo alone,...

journal_title：Blood

authors： Asano Y,Okamura S,Shibuya T,Harada M,Niho Y

更新日期：1988-11-01 00:00:00

abstract：:Human T-cell leukemia virus type I (HTLV-1) causes adult T-cell leukemia (ATL), a fatal T-cell leukemia resistant to chemotherapy, after more than 50 years of clinical latency from transmission through breast-feeding. Polyclonal expansion of virus-infected T cells predisposes them to transformation. Constitutive activ...

journal_title：Blood

authors： Watanabe M,Ohsugi T,Shoda M,Ishida T,Aizawa S,Maruyama-Nagai M,Utsunomiya A,Koga S,Yamada Y,Kamihira S,Okayama A,Kikuchi H,Uozumi K,Yamaguchi K,Higashihara M,Umezawa K,Watanabe T,Horie R

更新日期：2005-10-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is one of the most common acute leukemias in adults and children, yet significant numbers of patients relapse and die of disease. In this study, we identify the dependence of AML blasts on arginine for proliferation. We show that AML blasts constitutively express the arginine transporters ...

journal_title：Blood

authors： Mussai F,Egan S,Higginbotham-Jones J,Perry T,Beggs A,Odintsova E,Loke J,Pratt G,U KP,Lo A,Ng M,Kearns P,Cheng P,De Santo C

更新日期：2015-04-09 00:00:00

abstract：:Interleukin 2 (IL-2) rescued human natural killer (NK) KHYG-1 cells from apoptosis along with a reduction of ceramide. Conversely, an increase of ceramide inhibited IL-2-rescued survival. IL-2 deprivation-induced activation of acid sphingomyelinase (SMase) and inhibition of glucosylceramide synthase (GCS) and sphingom...

journal_title：Blood

authors： Taguchi Y,Kondo T,Watanabe M,Miyaji M,Umehara H,Kozutsumi Y,Okazaki T

更新日期：2004-11-15 00:00:00

abstract：:Reduced levels of somatic hypermutation (SHM) have recently been described in IgG-switched immunoglobulin genes in a minority of patients with common variable immunodeficiency (CVID), demonstrating a disruption of the normal linkage between isotype switch and SHM. To see if, irrespective of isotype, there is a tendenc...

journal_title：Blood

authors： Andersen P,Permin H,Andersen V,Schejbel L,Garred P,Svejgaard A,Barington T

更新日期：2005-01-15 00:00:00

abstract：:Mutations in the MYH9 gene encoding the nonmuscle myosin heavy chain IIA result in bleeding disorders characterized by a macrothrombocytopenia. To understand the role of myosin in normal platelet functions and in pathology, we generated mice with disruption of MYH9 in megakaryocytes. MYH9Delta mice displayed macrothro...

journal_title：Blood

authors： Léon C,Eckly A,Hechler B,Aleil B,Freund M,Ravanat C,Jourdain M,Nonne C,Weber J,Tiedt R,Gratacap MP,Severin S,Cazenave JP,Lanza F,Skoda R,Gachet C

更新日期：2007-11-01 00:00:00

abstract：:Phagocytes from X-linked chronic granulomatous disease (X-CGD) patients are deficient in their ability to generate superoxide because of a defective gene that encodes a heavy chain of cytochrome b, a critical component in the superoxide-generating pathway. Previously we have shown that a single in vivo treatment of se...

journal_title：Blood

authors： Ezekowitz RA,Sieff CA,Dinauer MC,Nathan DG,Orkin SH,Newburger PE

更新日期：1990-12-15 00:00:00

abstract：:Numerous studies have reported significant associations between ABO blood group and risk of cardiovascular disease. These studies have consistently demonstrated that thrombotic risk is significantly reduced in individuals in blood group O. Nevertheless, the biological mechanisms through which ABO influences hemostasis...

journal_title：Blood

authors： Ward SE,O'Sullivan JM,O'Donnell JS

更新日期：2020-12-17 00:00:00

abstract：:Patients with antineutrophil cytoplasmic antibodies (ANCAs) frequently develop severe vasculitis and glomerulonephritis. Although ANCAs, particularly antimyeloperoxidase (anti-MPO), have been shown to promote leukocyte adhesion in postcapillary venules, their ability to promote adhesion in the glomerular vasculature i...

journal_title：Blood

authors： Kuligowski MP,Kwan RY,Lo C,Wong C,James WG,Bourges D,Ooi JD,Abeynaike LD,Hall P,Kitching AR,Hickey MJ

更新日期：2009-06-18 00:00:00

abstract：:The kidney is involved in 70% of patients with immunoglobulin light-chain (AL) amyloidosis, but little is known on progression or reversibility of renal involvement, and criteria for renal response have never been validated. Newly diagnosed patients from the Pavia (n = 461, testing cohort) and Heidelberg (n = 271, val...

journal_title：Blood

authors： Palladini G,Hegenbart U,Milani P,Kimmich C,Foli A,Ho AD,Vidus Rosin M,Albertini R,Moratti R,Merlini G,Schönland S

更新日期：2014-10-09 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by the t(15;17)(q22;q11.2), which results in the PML-RARA fusion gene. In previous studies, we demonstrated that expression of a human PML-RARA complementary DNA in murine granulocyte precursor cells initiated the development of leukemia. However, leukemogenesis by P...

journal_title：Blood

authors： Le Beau MM,Bitts S,Davis EM,Kogan SC

更新日期：2002-04-15 00:00:00

abstract：:Histone deacetylase (HDAC) enzymatic activity has been linked to the transcription of DNA in cancers including multiple myeloma (MM). Therefore, HDAC inhibitors used alone and in combination are being actively studied as novel therapies in MM. In the present study, we investigated the preclinical activity of ACY-1215,...

journal_title：Blood

authors： Santo L,Hideshima T,Kung AL,Tseng JC,Tamang D,Yang M,Jarpe M,van Duzer JH,Mazitschek R,Ogier WC,Cirstea D,Rodig S,Eda H,Scullen T,Canavese M,Bradner J,Anderson KC,Jones SS,Raje N

更新日期：2012-03-15 00:00:00

abstract：:Hematopoietic stem cell (HSC) homeostasis is controlled by cytokine receptor-mediated Janus kinase 2 (JAK2) signaling. We previously found that JAK2 is promptly ubiquitinated upon cytokine stimulation. Whether a competing JAK2 deubiquitination activity exists is unknown. LNK is an essential adaptor protein that constr...

journal_title：Blood

authors： Donaghy R,Han X,Rozenova K,Lv K,Jiang Q,Doepner M,Greenberg RA,Tong W

更新日期：2019-04-04 00:00:00

abstract：:Hydroxyurea treatment of sickle cell mice improved their survival from pneumococcal pneumonia, counteracting the abnormally elevated inflammatory response and reducing invasion of bacteria into the bloodstream, through down regulation of E-selectin. ...

journal_title：Blood

authors： Hsu LL

更新日期：2012-02-23 00:00:00

abstract：:Mantle cell lymphoma (MCL) is a clinicopathologic entity that is difficult to diagnose on histopathologic criteria. Approximately 50% to 70% of MCL contain a t(11;14)(q13;q32) translocation involving the cyclin D1 gene. Irrespective of this rearrangement, almost all MCL show overexpression of the cyclin D1 gene at the...

journal_title：Blood

authors： de Boer CJ,Schuuring E,Dreef E,Peters G,Bartek J,Kluin PM,van Krieken JH

更新日期：1995-10-01 00:00:00

abstract：:A specially designed rotational viscometer was used to investigate the effects of the antiplatelet agent PGI2 in combination with theophylline on the response of human platelets subjected to shear stress. Samples of citrated platelet-rich plasma (PRP) were exposed to shear stress in the viscometer for a period of 5 mi...

journal_title：Blood

authors： Hardwick RA,Hellums JD,Peterson DM,Moake JL,Olson JD

更新日期：1981-10-01 00:00:00

abstract：:Myelotoxic injury in the bone marrow (BM) as a consequence of total body irradiation (TBI) or granulocyte colony-stimulating factor (G-CSF) mobilization results in the deposition of iC3b on BM stroma (stroma-iC3b). In the present study, we have examined how stroma-iC3b interacts with hematopoietic progenitor cells (HP...

journal_title：Blood

authors： Cramer DE,Allendorf DJ,Baran JT,Hansen R,Marroquin J,Li B,Ratajczak J,Ratajczak MZ,Yan J

更新日期：2006-01-15 00:00:00

abstract：:We have previously demonstrated that young adult DBA/2 (DBA) mice have more stem cells than C57BL/6 (B6) mice, as measured in a cobblestone area-forming cell (CAFC) assay using unfractionated marrow. To study the nature of this difference, we have now compared the proliferative fate of single, highly enriched Sca-1(+)...

journal_title：Blood

authors： de Haan G,Szilvassy SJ,Meyerrose TE,Dontje B,Grimes B,Van Zant G

更新日期：2000-08-15 00:00:00

abstract：:Deletion of TP53 gene, under routine assessment by fluorescence in situ hybridization analysis, connects with the worst prognosis in chronic lymphocytic leukemia (CLL). The presence of isolated TP53 mutation (without deletion) is associated with reduced survival in CLL patients. It is unclear how these abnormalities a...

journal_title：Blood

authors： Malcikova J,Smardova J,Rocnova L,Tichy B,Kuglik P,Vranova V,Cejkova S,Svitakova M,Skuhrova Francova H,Brychtova Y,Doubek M,Brejcha M,Klabusay M,Mayer J,Pospisilova S,Trbusek M

更新日期：2009-12-17 00:00:00

abstract：:Despite major therapeutic advances, most mature B-cell malignancies remain incurable. Compelling evidence suggests that crosstalk with accessory stromal cells in specialized tissue microenvironments, such as the bone marrow and secondary lymphoid organs, favors disease progression by promoting malignant B-cell growth ...

journal_title：Blood

authors： Burger JA,Ghia P,Rosenwald A,Caligaris-Cappio F

更新日期：2009-10-15 00:00:00

abstract：:miRNAs have emerged as master regulators of cancer-related events. miRNA dysregulation also occurs in Kaposi sarcoma (KS). Exploring the roles of KS-associated miRNAs should help to identify novel angiogenesis and lymphangiogenesis pathways. In the present study, we show that Kaposi sarcoma-associated herpesvirus (KSH...

journal_title：Blood

authors： Wu YH,Hu TF,Chen YC,Tsai YN,Tsai YH,Cheng CC,Wang HW

更新日期：2011-09-08 00:00:00

abstract：:The last 2 years have seen much excitement in the field of genetics with the identification of a formerly unappreciated level of "structural variation" within the normal human genome. Genetic structural variants include deletions, duplications, and inversions in addition to the recently discovered, copy number variant...

journal_title：Blood

authors： Mullally A,Ritz J

更新日期：2007-02-15 00:00:00

abstract：:Inactivation of the retinoblastoma tumor-suppressor gene (RB-1) has been associated with tumorigenicity in various human malignancies. In chronic lymphoid leukemias of B-cell origin (B-CLL) an involvement of RB-1 has been suggested based on cytogenetic data. We examined RB-1 and its chromosomal locus 13q14 in 35 cases...

journal_title：Blood

authors： Stilgenbauer S,Döhner H,Bulgay-Mörschel M,Weitz S,Bentz M,Lichter P

更新日期：1993-04-15 00:00:00

abstract：:Fibronectin is an adhesive protein that can promote phagocytosis and endothelial cell adhesion. Plasma fibronectin declines following burn in animals and patients, potentially due to its complexing with circulating collagenous debris as well as its rapid binding to sites of tissue injury. Such depletion of fibronectin...

journal_title：Blood

authors： La Celle P,Blumenstock FA,Saba TM

更新日期：1991-05-01 00:00:00

abstract：:Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation system, synthesized in endothelial cells, which has recently been shown to play an important role in the regulation of activated coagulation factors at the endothelial cell surface. In the present study we investigated t...

journal_title：Blood

authors： Hansen JB,Olsen R,Webster P

更新日期：1997-11-01 00:00:00

abstract：:The serpin antithrombin III (AT III) is reported to have hemostasis-regulating and anti-inflammatory properties. To determine its ability to influence thrombin-independent leukocyte responses, the direct effects of the AT III concentrate Kybernin P and a monoclonal antibody-purified AT III on neutrophil migration were...

journal_title：Blood

authors： Dunzendorfer S,Kaneider N,Rabensteiner A,Meierhofer C,Reinisch C,Römisch J,Wiedermann CJ

更新日期：2001-02-15 00:00:00

abstract：:We used both radiolabeled and fluorescein-labeled antiglobulins in assays to detect antibodies against platelets in multiply transfused patients to determine the value of these tests in predicting the outcome of platelet transfusion in such patients. In 15 allosensitized patients, we studied 68 single-donor platelet t...

journal_title：Blood

authors： Ware R,Reisner EG,Rosse WF

更新日期：1984-05-01 00:00:00