Abstract:
:We have cloned the human gene encoding the transcription factor T. T protein is vital for the formation of posterior mesoderm and axial development in all vertebrates. Brachyury mutant mice, which lack T protein, die in utero with abnormal notochord, posterior somites, and allantois. We have identified human T genomic clones and derived the mRNA sequence and gene structure. There is 91% amino acid identity between human and mouse T proteins overall and complete identity across 77 amino acids of the T-box motif within the DNA-binding domain. Human T expression is very similar to that found for T in other vertebrate species and is confined to cells derived from the notochord. The human T gene maps to chromosome 6q27 and is only the second human member of the T-box gene family to be described.
journal_name
Genome Resjournal_title
Genome researchauthors
Edwards YH,Putt W,Lekoape KM,Stott D,Fox M,Hopkinson DA,Sowden Jdoi
10.1101/gr.6.3.226subject
Has Abstractpub_date
1996-03-01 00:00:00pages
226-33issue
3eissn
1088-9051issn
1549-5469journal_volume
6pub_type
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