Abstract:
:DNA methylation is found in many eukaryotes, but its function is still controversial. We have studied the methylation of plant and animal genomes using a PCR-based technique amenable for high throughput. Repetitive elements are methylated in both organisms, but whereas most mammalian exons are methylated, plant exons are not. Thus, targeting of methylation specifically to transposons appears to be restricted to plants. We propose that the mechanistic basis of this difference may involve RNA interference. Sequencing strategies that depend on differential methylation are predicted to have different outcomes in plant and mammalian genomes.
journal_name
Genome Resjournal_title
Genome researchauthors
Rabinowicz PD,Palmer LE,May BP,Hemann MT,Lowe SW,McCombie WR,Martienssen RAdoi
10.1101/gr.1784803subject
Has Abstractpub_date
2003-12-01 00:00:00pages
2658-64issue
12eissn
1088-9051issn
1549-5469pii
13/12/2658journal_volume
13pub_type
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