Abstract：
:Hybrid epidemiologic designs combining elements from case-control studies and cohort studies are reviewed. Firstly, the characteristics of selection of both index group and reference group are commented on. The selection of cases required a population-based disease registry. The type of selection of reference group permits to identify the main hybrid designs: the case-cohort approach, sampling from the base at the beginning of risk period, and the nested (within a cohort) case-control studies, usually with a matched density sampling. The assumptions needed for estimating without bias relative risk or rate ratio via odds ratio and without needing the condition of disease rarity are revised. Advantages, uses, and drawbacks are summarized. Lastly, general guidelines for the analysis of these designs are displayed.
journal_name
Gac Sanitjournal_title
Gaceta sanitariaauthors
Delgado-Rodríguez M,Sillero Mdoi
10.1016/s0213-9111(95)71216-xsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
42-52issue
46eissn
0213-9111issn
1578-1283pii
S0213-9111(95)71216-Xjournal_volume
9pub_type
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