Abstract:
OBJECTIVE:To determine the incidence of immunologic change in the percentage of CD4+ T lymphocytes in HIV 1/2 positive patients in the first quarter after influenza vaccination (P-CIR) and to compare the demographic and clinical characteristics associated with this change. METHODS:We studied 105 patients with HIV/AIDS in a retrospective hospital cohort between 2001-2006. P-CIR was considered as a decrease of >3% in the prevaccination CD4+ percentage. Crude and adjusted OR (sex, age, antiretroviral therapy, clinical stability, prevaccination viremia and prevaccination total CD4) were evaluated by logistic regression (95%CI). RESULTS:The incidence of P-CIR was 33.3%. P-CIR was persistent in 31.4% for 7 months after vaccination regardless of high prevaccination viremia. No association was found between demographic and clinical variables and P-CIR [crude OR: 0.90 (0.17-4.8); adjusted OR: 1.09 (0.17-6.8)]. CONCLUSIONS:The results showed that the immunological change after vaccination was not inconsiderable. However, this change was mainly transient.
journal_name
Gac Sanitjournal_title
Gaceta sanitariaauthors
Barrionuevo Rosas L,Masuet Aumatell C,Ramon Torrell JMdoi
10.1016/j.gaceta.2008.10.011subject
Has Abstractpub_date
2009-07-01 00:00:00pages
315-21issue
4eissn
0213-9111issn
1578-1283pii
S0213-9111(09)00093-4journal_volume
23pub_type
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