The transcripts of the apomucin genes MUC2, MUC4, and MUC5AC are large and appear as distinct bands.

abstract：:Influenza virus neuraminidase inhibitors (NAIs), currently used as anti-influenza drugs, can lead to the appearance of drug-resistant variants. Resistance to NAIs appears due to mutations in the active site of the neuraminidase (NA) molecule that decrease the NA enzymatic activity and sometimes in the hemagglutinin (H...

journal_title：Glycoconjugate journal

authors： Mochalova L,Bright R,Xu X,Korchagina E,Chinarev A,Bovin N,Klimov A

更新日期：2010-04-01 00:00:00

abstract：:If we predict the host range of new or mutant influenza virus in advance, we are able to measure against pandemic human influenza immediately after the new virus emerges somewhere. Influenza viral hemagglutinin(HA)-sialoside receptor interaction is a target event for in silico chemical prediction studies about the vir...

journal_title：Glycoconjugate journal

authors： Sawada T,Hashimoto T,Tokiwa H,Suzuki T,Nakano H,Ishida H,Kiso M,Suzuki Y

更新日期：2008-12-01 00:00:00

abstract：:Human skin fibroblasts were incubated with a fluorogenic xyloside, 4-methylumbelliferyl-beta-D-xyloside (Xyl-MU), in the presence or absence of tunicamycin. The xyloside-initiated glycosaminoglycans (GAG-MUs) were isolated from the culture medium, and their structures characterized. When the cells were incubated with ...

journal_title：Glycoconjugate journal

authors： Takagaki K,Tazawa T,Munakata H,Nakamura T,Endo M

更新日期：1998-05-01 00:00:00

abstract：:Human alpha1,3-fucosyltransferase V and -VI (hFucTV and -VI) each contain four potential N-glycosylation sites (hFucTV: Asn60, Asn105, Asn167 and Asn198 and hFucTVI: Asn46, Asn91, Asn153 and Asn184). Glycosylation of the two N-terminal potential N-glycosylation sites (hFucTV: Asn60, Asn105 and hFucTVI: Asn46 and Asn91...

journal_title：Glycoconjugate journal

authors： Christensen LL,Bross P,Ørntoft TF

更新日期：2000-12-01 00:00:00

abstract：:The small keratan sulphate proteoglycan, fibromodulin, has been isolated from pooled human articular cartilage. The main chain repeat region and the chain caps from the attached N-linked keratan sulphate chains have been fragmented by keratanase II digestion, and the oligosaccharides generated have been reduced and is...

journal_title：Glycoconjugate journal

authors： Lauder RM,Huckerby TN,Nieduszynski IA

更新日期：1997-08-01 00:00:00

abstract：:Oral exposure to lectins or the presence or absence of bacteria in the rat small intestine were shown by histological methods using anti-lectin antibodies or digoxigenin-labelled lectins to have major effects on the state of glycosylation of lumenal membranes and cytoplasmic glycoconjugates of epithelial cells. Taken ...

journal_title：Glycoconjugate journal

authors： Pusztai A,Ewen SW,Grant G,Peumans WJ,Van Damme EJ,Coates ME,Bardocz S

更新日期：1995-02-01 00:00:00

abstract：:The glycosylation abilities of snails deserve attention, because snail species serve as intermediate hosts in the developmental cycles of some human and cattle parasites. In analogy to many other host-pathogen relations, the glycosylation of snail proteins may likewise contribute to these host-parasite interactions. H...

journal_title：Glycoconjugate journal

authors： Stepan H,Pabst M,Altmann F,Geyer H,Geyer R,Staudacher E

更新日期：2012-05-01 00:00:00

abstract：:Full proton NMR assignments have been achieved for the alpha(1-3)-linked fucose residues contained in alkaline borohydride reduced keratan sulphate chains derived from bovine articular cartilage. This involved 500 MHz spectroscopy at 60 degrees C and included COSY and RELAYED-COSY determinations. ...

journal_title：Glycoconjugate journal

authors： Huckerby TN,Nieduszynski IA,Brown GM,Cockin GH

更新日期：1991-02-01 00:00:00

abstract：:Multidisciplinary approaches by a number of investigators have established that cell-surface carbohydrates are integral components of recognition systems regulating survival, migration, adhesion, growth and differentiation of various cells. Our own experience and contributions to this exciting field are described. We ...

journal_title：Glycoconjugate journal

authors： Muramatsu T

更新日期：2000-07-01 00:00:00

abstract：:Non-acid and acid glycosphingolipids were isolated from feces of one litter of germ-free rats from day 17 to day 51. Quantitative and qualitative changes described for small intestine of conventional rats [Bouhours D, Bouhours J-F (1981) Biochem Biophys Res Commun 99:1384-89] were also found in the feces of these germ...

journal_title：Glycoconjugate journal

authors： Larson G,Midtvedt T

更新日期：1989-01-01 00:00:00

abstract：:Poly-N-acetyllactosamine (poly-LacNAc) structures have been identified as important ligands for galectin-mediated cell adhesion to extra-cellular matrix (ECM) proteins. We here present the biofunctionalization of surfaces with poly-LacNAc structures and subsequent binding of ECM glycoproteins. First, we synthesized be...

journal_title：Glycoconjugate journal

authors： Sauerzapfe B,Krenek K,Schmiedel J,Wakarchuk WW,Pelantová H,Kren V,Elling L

更新日期：2009-02-01 00:00:00

abstract：:CLEC-2 was first identified by sequence similarity to C-type lectin-like molecules with immune functions and has been reported as a receptor for the platelet-aggregating snake venom toxin rhodocytin and the endogenous sialoglycoprotein podoplanin. Recent researches indicate that CLEC-2-deficient mice were lethal at th...

journal_title：Glycoconjugate journal

authors： Wang L,Ren S,Zhu H,Zhang D,Hao Y,Ruan Y,Zhou L,Lee C,Qiu L,Yun X,Xie J

更新日期：2012-08-01 00:00:00

abstract：:UDP-2-(2-ketopropyl)galactose (1) has been utilized as a valuable probe for profiling proteins modified by O-GlcNAc. In this work, we developed a protocol for efficient synthesis of 1. Thus, 2-methallylgalactose derivative 11, a synthetic intermediate for the compound 1, was prepared by stereoselective iodination and ...

journal_title：Glycoconjugate journal

authors： Sakamoto Y,Ohta T,Ito Y

更新日期：2015-10-01 00:00:00

abstract：:Proteoglycans contain a unique carbohydrate component, glycosaminoglycan, which consists of repeating, typically sulfated disaccharides, and is capable of interacting with diverse molecules. Specific, clustered arrangements of sulfate on the glycosaminoglycan backbone form binding sites for many biologically important...

journal_title：Glycoconjugate journal

authors： Yanagishita M,Podyma-Inoue KA,Yokoyama M

更新日期：2009-11-01 00:00:00

abstract：:Gastric carcinoma is a major cause of cancer death worldwide and, like most human cancers, probably develops after environmental insults acting on normal individuals and/or individuals with increased genetic susceptibility. Mucins are attractive molecules to study the relationship between genetics and environment beca...

journal_title：Glycoconjugate journal

authors： Carvalho F,Seruca R,David L,Amorim A,Seixas M,Bennett E,Clausen H,Sobrinho-Simões M

更新日期：1997-01-01 00:00:00

abstract：:GM3 ganglioside interacts specifically with complex-type N-linked glycans having multivalent GlcNAc termini, as shown for (1) and (2) below. (1) Oligosaccharides (OS) isolated from ConA-non-binding N-linked glycans of ovalbumin, whose structures were identified as penta-antennary complex-type with bisecting GlcNAc, ha...

journal_title：Glycoconjugate journal

authors： Yoon SJ,Nakayama K,Takahashi N,Yagi H,Utkina N,Wang HY,Kato K,Sadilek M,Hakomori SI

更新日期：2006-12-01 00:00:00

abstract：:Chondroitin sulfate (CS) and dermatan sulfate (DS) were extracted and purified from skins or bones of salmon (Salmo salar), snakehead (Channa argus), monkfish (Lophius litulon) and skipjack tuna (Katsuwonus pelamis). Size, structural sequences and sulfate groups of oligosaccharides in the purified CS and DS could be c...

journal_title：Glycoconjugate journal

authors： Lin N,Mo X,Yang Y,Zhang H

更新日期：2017-04-01 00:00:00

abstract：:Twenty different human and animal tissues were investigated for the presence of polyglycosylceramides. The glycolipids were isolated by peracetylation of dry tissue residues left after conventional lipid extraction, followed by extraction with chloroform and subsequent Sephadex LH-20, Sephadex LH-60 and silica gel chr...

journal_title：Glycoconjugate journal

authors： Miller-Podraza H,Stenhagen G,Larsson T,Andersson C,Karlsson KA

更新日期：1997-02-01 00:00:00

abstract：:We have used two methods to evaluate the level of expression of Gb3Cer in several human leukaemia/lymphoma cell lines representative of the myeloid (K562, KG-1, HL-60, and lymphoid (Reh, Daudi, Raji, RPMI 8226, CCRF-CEM, MOLT-4) lineages blocked at varied stages of differentiation. TLC immunostaining of glycolipid ext...

journal_title：Glycoconjugate journal

authors： Stults CL,Larsen RD,Macher BA

更新日期：1995-10-01 00:00:00

abstract：:Humans, in contrast to other mammals, do not synthesize N-glycolyl-neuraminic acid (Neu5Gc) due to a deletion in the gene (cmah) encoding the enzyme responsible for this conversion, the cytidine monophospho-N-acetyl-neuraminic acid hydroxylase (CMP-Neu5Ac hydroxylase). The detection of considerable amounts of Neu5Gc-s...

journal_title：Glycoconjugate journal

authors： Casadesús AV,Fernández-Marrero Y,Clavell M,Gómez JA,Hernández T,Moreno E,López-Requena A

更新日期：2013-10-01 00:00:00

abstract：:Two azidohexasaccharide building blocks, of which the glycosyl acceptor was the 5-(methoxycarbonyl)pentyl glycoside, were coupled using the trichloroacetimidate technology. The 12 azido functions present in the dodecasaccharide thus formed were then converted to amino groups using hydrogen sulfide as a reducing reagen...

journal_title：Glycoconjugate journal

authors： Ogawa Y,Kovac P

更新日期：1997-06-01 00:00:00

abstract：:Frog integumentary mucin B.1 (FIM-B.1) represents a polymorphic extracellular mosaic protein which contains tandemly arranged serine/threonine-rich modules as well as cysteine-rich domains. The latter are probably important for oligomerization of FIM-B.1 and have also been found in many proteins of the complement casc...

journal_title：Glycoconjugate journal

authors： Joba W,Hoffmann W

更新日期：1996-10-01 00:00:00

abstract：:C-Mannosylation, a protein-modification found in various eukaryotes, involves the attachment of a single mannose molecule to selected tryptophan residues of proteins. Since C-mannosyl tryptophan (CMW) was detected in human urine, it is generally thought that CMW is not catabolized inside our body and instead is excret...

journal_title：Glycoconjugate journal

authors： Hossain TJ,Manabe S,Ito Y,Iida T,Kosono S,Ueda K,Hosomi A,Inoue D,Suzuki T

更新日期：2018-04-01 00:00:00

abstract：:Lubrication of mammalian joints is mediated by lubricin, a product of megakaryocyte stimulating factor gene (MSF; GenBank accession #U70136) expression. Lubricin (M(r) approximately 240 kDa) is a mucinous glycoprotein which is 50% (w/w) post-translationally modified with beta(1-3)Gal-GalNAc incompletely capped with Ne...

journal_title：Glycoconjugate journal

authors： Jay GD,Harris DA,Cha CJ

更新日期：2001-10-01 00:00:00

abstract：:The N-glycans from soluble extracts of ten pollens were examined. The pyridylaminated oligosaccharides derived from these sources were subject to gel filtration and reverse-phase HPLC, in conjunction with exoglycosidase digests, and in some cases matrix-assisted laser desorption-ionisation mass spectrometry. In compar...

journal_title：Glycoconjugate journal

authors： Wilson IB,Altmann F

更新日期：1998-11-01 00:00:00

abstract：:The uncovering enzyme (UCE) removes N-acetylglucosamine from lysosomal enzymes to uncover the mannose 6-phosphate (Man-6-P) determinant necessary for targeting these enzymes to lysosomes. Failure to create the Man-6-P determinant is one cause of lysosomal storage diseases. Despite its medical importance, little struct...

journal_title：Glycoconjugate journal

authors： Wei Y,Yen TY,Cai J,Trent JO,Pierce WM,Young WW Jr

更新日期：2005-02-01 00:00:00

abstract：:A group of fluorescent statistical glycopolymers, prepared via reversible addition-fragmentation chain-transfer (RAFT)-based polymerizations, were successfully employed in lectin-mediated bacterial binding studies. The resultant glycopolymers contained three different monomers: N-(2-hydroxyethyl) acrylamide (HEAA), N-...

journal_title：Glycoconjugate journal

authors： Wang W,Chance DL,Mossine VV,Mawhinney TP

更新日期：2014-02-01 00:00:00

abstract：:Blood group antigen-related oligosaccharides have been implicated in growth regulation, cell mobility control and adhesion; we are therefore interested in the localization of receptors for these oligosaccharides in tumour cells. Labelled neoglycoconjugates that carry synthetic sugar structures are suitable tools to de...

journal_title：Glycoconjugate journal

authors： Kayser K,Bovin NV,Zemlyanukhina TV,Donaldo-Jacinto S,Koopmann J,Gabius HJ

更新日期：1994-08-01 00:00:00

abstract：:In this study, a novel water soluble polysaccharide (named GFP-4) was extracted from Grifola frondosa at 4 oC, and its preliminary structure and inhibitory effects on human gastric carcinoma MKN-45 cells through the Fas/FasL death receptor apoptosis pathway were investigated. High-performance gel permeation chromatogr...

journal_title：Glycoconjugate journal

authors： Liu C,Ji HY,Wu P,Yu J,Liu AJ

更新日期：2020-08-01 00:00:00

abstract：:The N-glycan moiety of ascorbic acid oxidase from zucchini (Cucurbita pepo) has been described to be a core-pentasaccharide with a xylose [D'Andrea et al. (1988) Glycoconjugate J 5:151-7]. Ascorbic acid oxidase is sometimes used to characterize antibodies directed against carbohydrate determinants on plant glycoprotei...

journal_title：Glycoconjugate journal

authors： Altmann F

更新日期：1998-01-01 00:00:00